Navigation Links
On a fly's wing, scientists tally evolution's winners and losses

The complete sequencing of human chromosome 17 and mouse chromosome 11 offers unique insights into the evolution of the genome of higher mammals, said a Baylor College of Medicine researcher who participated in this effort reported in today's issue of the journal Nature.

The work represents the first time that a mouse chromosome has been completely sequenced and annotated, said Dr. James R. Lupski, vice chair and professor in the BCM department of molecular and human genetics and professor of pediatrics. This presented scientists with the opportunity to examine intensively the similarities and differences in the DNA sequence of human and mouse.

Lupski was brought into the work while he was on sabbatical at the Wellcome Trust Sanger Institute in Cambridge, England, last year. The Sanger Institute and the Broad Institute of MIT and Harvard were the primary institutions involved in the sequencing effort. However, scientists at Sanger dubbed a portion of chromosome 17 the Lupski segment because he has spent so much time dealing with that portion of the genome in his effort to identify gene mutations that result in disease. They sought his expertise on the chromosome.

Chromosome 17 is particularly rich in disease genes such as BRCA1 (the first identified breast cancer gene); NF1 (neurofibromatosis); the gene associated with repairing DNA damage that might otherwise result in cancer (TP53); Smith-Magenis syndrome (SMS), and Charcot-Marie-Tooth type 1A10 (the most common type of inherited nerve disorder [CMT1A]).

The study of this chromosome gives a clearer picture of how genome changes through evolution, Lupski said. For example, breaks in synteny or the maintenance of the order of genes between species coincide with changes in the architecture of the chromosome itself. In some cases, DNA repeats get in the way. In others, there are rearrangements of the genome that occur during the process of cell reproduction.

"As we go up the mammalian line, and particularly in primate, it is obvious that rearrangement in the genome is the predominant force in the evolution of genomes," said Lupski. That is particularly evident in this report that allows carefully comparison of the mouse and human chromosomes.

"Perhaps one way to evolve faster is not by making changes in base pairs (the chemicals that make up DNA), but by changing chunks of genome," said Lupski.

The sequencing of chromosome 17 and mouse chromosome 11 was an international effort involving researchers from around the globe.


'"/>

Source:University of Wisconsin-Madison


Related biology news :

1. Fruit flys beating heart helps identify human heart disease genes
2. Hard-wiring the fruit flys visual system
3. Dragonflys metabolic disease provides clues about human obesity
4. Wisconsin scientists grow critical nerve cells
5. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
6. UAB scientists discover the origin of a mysterious physical force
7. Fox Chase Cancer Center scientists identify immune-system mutation
8. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
9. U-M scientists find genes that control growth of common skin cancer
10. UCLA scientists transform HIV into cancer-seeking missile
11. RNA project to create language for scientists worldwide
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... Australia , March 2, 2017 Australian ... Ltd (ASX: CYP), has signed an agreement with ... from the Monash Biomedicine Discovery Institute and Department of ... to conduct a further preclinical study to support the ... treatment of asthma.  Asthma is a ...
(Date:2/27/2017)...   Strategic Cyber Ventures , the industry,s first ... $3.5 million investment in  Polarity , the first commercial ... DC based and is led by cybersecurity veterans ... Ron Gula , also a longtime cybersecurity veteran and ... series A round of funding. This new funding will ...
(Date:2/21/2017)... 2017 Der weltweite Biobanking-Sektor wird ... einem Gespräch mit mehr als 50 Vertretern aus verschiedenen Branchen ... gilt, um diese Prognose zu realisieren. ... Zu den ... finanziellen Mittel für die Biobank, die Implementierung Zeit sparender ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... Summary This report provides all the information you ... and activities since 2010. Description The Partnering Deals and ... partnering activity of one of the world,s leading life sciences ... purchase to ensure inclusion of the most up to date ... delivered in PDF format within 1 working day of receipt ...
(Date:3/28/2017)... 28, 2017 Dr. Chris Yu ... corporation Anpac Bio-Medical Science Company , announced ... record, processing and reporting over 40,000 cases worldwide ... (CDA) liquid biopsy tests. Described ... Summit publications, Anpac Bio,s CDA medical devices and ...
(Date:3/28/2017)... , ... March 28, 2017 ... ... launch its brand-new, fully-certified hygienic SWB805 MultiMountTM weigh modules. These weigh modules ... and certified by National Sanitation Foundation (NSF). , As fully integrated weighing ...
(Date:3/27/2017)... ... March 27, 2017 , ... IsoPlexis ... against cancer, autoimmune disease and more through a single-cell precision engineering platform, today ... analysis platform developed in the laboratory of Dr. James Heath at the ...
Breaking Biology Technology: