Navigation Links
On a fly's wing, scientists tally evolution's winners and losses

The complete sequencing of human chromosome 17 and mouse chromosome 11 offers unique insights into the evolution of the genome of higher mammals, said a Baylor College of Medicine researcher who participated in this effort reported in today's issue of the journal Nature.

The work represents the first time that a mouse chromosome has been completely sequenced and annotated, said Dr. James R. Lupski, vice chair and professor in the BCM department of molecular and human genetics and professor of pediatrics. This presented scientists with the opportunity to examine intensively the similarities and differences in the DNA sequence of human and mouse.

Lupski was brought into the work while he was on sabbatical at the Wellcome Trust Sanger Institute in Cambridge, England, last year. The Sanger Institute and the Broad Institute of MIT and Harvard were the primary institutions involved in the sequencing effort. However, scientists at Sanger dubbed a portion of chromosome 17 the Lupski segment because he has spent so much time dealing with that portion of the genome in his effort to identify gene mutations that result in disease. They sought his expertise on the chromosome.

Chromosome 17 is particularly rich in disease genes such as BRCA1 (the first identified breast cancer gene); NF1 (neurofibromatosis); the gene associated with repairing DNA damage that might otherwise result in cancer (TP53); Smith-Magenis syndrome (SMS), and Charcot-Marie-Tooth type 1A10 (the most common type of inherited nerve disorder [CMT1A]).

The study of this chromosome gives a clearer picture of how genome changes through evolution, Lupski said. For example, breaks in synteny or the maintenance of the order of genes between species coincide with changes in the architecture of the chromosome itself. In some cases, DNA repeats get in the way. In others, there are rearrangements of the genome that occur during the process of cell reproduction.

"As we go up the
'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. Fruit flys beating heart helps identify human heart disease genes
2. Hard-wiring the fruit flys visual system
3. Dragonflys metabolic disease provides clues about human obesity
4. Wisconsin scientists grow critical nerve cells
5. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
6. UAB scientists discover the origin of a mysterious physical force
7. Fox Chase Cancer Center scientists identify immune-system mutation
8. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
9. U-M scientists find genes that control growth of common skin cancer
10. UCLA scientists transform HIV into cancer-seeking missile
11. RNA project to create language for scientists worldwide
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: fly wing scientists tally evolution winners and losses

(Date:4/23/2014)... technique used to read quickly. It involves visual ... words and/ or sentences. Similarly to humans, biological ... "read" genetic information. Genes that need to be ... the encoding message, the easier it will be ... Gulbenkian de Cincia (IGC, Portugal) and Centre for ...
(Date:4/22/2014)... -- There are all sorts of signaling strategies in ... colorful tails; satin bowbirds build specialized stick structures, called ... and European bitterling males show off bright nuptial coloration ... method to communicate with others. , ... have profound fitness implications for individuals that are either ...
(Date:4/22/2014)... 22, 2014) Biotechnology scientists must be aware of ... and licensing guidelines, according to a new paper from ... in the current issue of the journal Regenerative ... 2013 U.S. Supreme Court ruling in the case Association ... occurring genes are unpatentable. The court case and rulings ...
Breaking Biology News(10 mins):Cell division speed influences gene architecture 2Best practices in communication for the animal world 2Best practices in communication for the animal world 3New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3
... such, they are relatively well studied, especially in the ... most thoroughly. First eastern US butterfly species were described ... himself, over 250 years ago. For the last ... species diversity of eastern butterflies, and every nook and ...
... A*STAR,s Institute of Molecular and Cell Biology (IMCB) have ... the pathway leading to memory and learning impairment. The ... and could be used to explain defects in the ... established knowledge could potentially facilitate exploration of strategies to ...
... plant that,s been known to drive people daffy. It,s one ... a hard-to-control weed in ponds and small lakes. But it,s ... source to produce pharmaceuticals. Now, the genome of Greater Duckweed ... as a biofuel source a big boost. In a paper ...
Cached Biology News:Two new butterfly species discovered in eastern USA 2A*STAR scientists discover protein's role in human memory and learning functions 2Pond-dwelling powerhouse's genome points to its biofuel potential 2Pond-dwelling powerhouse's genome points to its biofuel potential 3Pond-dwelling powerhouse's genome points to its biofuel potential 4
(Date:1/15/2014)... interface is the device," Nobel laureate Herbert Kroemer ... be found at the junctures where layers of ... nanotechnology, the interfaces between layers of metal oxides ... high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics and ...
(Date:1/15/2014)... Look inside the new Preferred Solutions® catalog ... from fluid handling to instruments to supplies. Many items ... order. , Preferred Solutions features a full selection ... model for precise flow control and dispensing to I/P® ...
(Date:1/15/2014)... 2014 This webinar will focus on ... safety assessment in biosimilars. , Regulatory frameworks are evolving ... development, however the complex nature of biopharmaceuticals makes the ... efficacy extremely challenging. Based on the specific aspects of ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
Breaking Biology Technology:A deeper look at interfaces 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... , a biotechnology company focused on the development and ... has entered into an in-vitro diagnostics patent license agreement ... , ,Under the agreement, which will be effective July ... in its products. Prodesse also receives the authority to ...
... monthly column, "Buzz Networks," will provide insights, descriptions, analysis, ... and concepts that are gaining credibility and providing utility ... deeply into the underlying technology, but rather will focus ... platforms. We look forward to your feedback and participation ...
... Wis. - It's not often that a tax is ... consumers start popping champagne corks over the recent elimination of ... know that getting some of their money back will require ... United States Treasury ruling has effectively eliminated the ...
Cached Biology Technology:Social computing in the Web 2.0 era 2Social computing in the Web 2.0 era 3Social computing in the Web 2.0 era 4Social computing in the Web 2.0 era 5Elimination of phone tax tempered by paperwork 2Elimination of phone tax tempered by paperwork 3
TRIAL SIZE Anti-Kaede [2F4] Monoclonal Research Focus: tag Storage: -20C Shipping Temperature: 4C...
AANAT [Arylalkylamine N-acetyltransferase; EC 2.3.1.87]...
TUP1 Market Segment: Molecular Biology...
NANS Immunogen: NANS (NP_061819, 260 a.a. ~ 360 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: