Navigation Links
Old memory traces in brain may trigger chronic pain

Why do so many people continue to suffer from life-altering, chronic pain long after their injuries have actually healed"

The definitive answer -- and an effective treatment -- has long eluded scientists. Traditional analgesic drugs, such as aspirin and morphine derivatives, haven’t worked very well.

A Northwestern University researcher has found a key source of chronic pain appears to be an old memory trace that essentially gets stuck in the prefrontal cortex, the site of emotion and learning. The brain seems to remember the injury as if it were fresh and can’t forget it.

With new understanding of the pain source, Vania Apkarian, professor of physiology, and of anesthesiology, at Northwestern’s Feinberg School of Medicine, has identified a drug that controls persistent nerve pain by targeting the part of the brain that experiences the emotional suffering of pain. The drug is D-Cycloserine, which has been used to treat phobic behavior over the past decade.

In animal studies, D-Cycloserine appeared to significantly diminish the emotional suffering from pain as well as reduce the sensitivity of the formerly injured site. It also controlled nerve pain resulting from chemotherapy, noted Apkarian, who is a member of the Robert H. Lurie Comprehensive Cancer Center at Northwestern University.

The drug has long-term benefits. Animals appeared to be pain free 30 days after the last dose of a 30-day regime of D-Cycloserine.

The study, funded by the National Institutes of Health, will be published in the journal Pain this fall. (It has been published on-line.)

“In some ways, you can think of chronic pain as the inability to turn off the memory of the pain,” Apkarian said. “What’s exciting is that we now may be relieving what has clinically been the most difficult to treat—the suffering or the emotional component of pain.”

Scientists have always tried to understand pain from
'"/>

Source:Northwestern University


Page: 1 2 3

Related biology news :

1. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
2. Structure-building cell signals also may influence learning and memory
3. Mice brains shrink during winter, impairing some learning and memory
4. Montreal researchers probe the genetic basis of memory
5. U of MN researchers reverse memory loss in mice
6. Researchers know what you were about to say; fMRI used to detect memory storage and retrieval
7. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
8. Tracking the memory trace
9. Learning and memory stimulated by gut hormone
10. Mechanism for memory revealed in neurons of electric fish
11. Activation of a protein solidifies fear memory in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Old memory traces brain may trigger chronic pain

(Date:9/21/2014)... significantly less likely to report taking iron supplements before ... who are developing normally, a study by researchers with ... iron intake was associated with a five-fold greater risk ... 35 or older at the time of the child,s ... as obesity hypertension or diabetes. , The research is ...
(Date:9/21/2014)... Contrary to what was previously thought, newborn immune T ... response to bacteria, according to a new study led ... very differently to that of adults, babies may still ... the study published in the journal Nature Medicine ... several different types of immune cells, including neutrophils which ...
(Date:9/19/2014)... University of Oklahoma biology professor will study the unique ... that could eventually benefit people,s health. The OU ... the energy required to produce the signals used to ... electric signals at a rate of 500-600 discharges a ... for the electric fish are extreme, but necessary for ...
Breaking Biology News(10 mins):Mothers of children with autism less likely to have taken iron supplements 2Immune system of newborn babies is stronger than previously thought 2
... reveals the interaction of genetic and environmental factors such ... explained Dr. Matthias Elstner of the Neurological Clinic of ... study. In addition, this genome-wide expression and association study ... both disease risk and therapy response ( Annals of ...
... not all the same when it comes to risk of ... researcher shows key differences among Hispanic populations that doctors should ... cardiovascular disease in this large and growing subset of the ... January 19, 2009 Journal of the American College of ...
... new quarterly newsletter for academic librarians and information professionals. ... developments at OUP and across the publishing world. ... and member of the Editorial Team said: ,After careful ... developed a strong and broad source of information for ...
Cached Biology News:Genetic risk factor identified for Parkinson's disease 2Crucial differences found among Latino populations facing heart disease risks 2
(Date:9/21/2014)... 21, 2014 Chemical Sciences play ... such as clean air and safe water, healthy ... products. Chemists, environmentalists, food scientists, educators, and scientists ... in the field of Chemistry for the national ... is one of the fastest emerging Sciences, accelerating ...
(Date:9/20/2014)... Friesland, Netherlands (PRWEB) September 20, 2014 ... cell technologies to perform a groundbreaking surgery at the ... incident, the mare's superficial digital flexor tendon was ruptured ... this kind of injury is a death sentence for ... MediVet America stem cell treatments . This ...
(Date:9/19/2014)... Scientists at NYU Langone Medical Center have found ... the process for turning adult cells into so-called pluripotent ... C. Using the new technique in mice, the researchers ... skin cells by more than 20-fold compared with the ... reliable, and thus should generally accelerate research aimed at ...
(Date:9/19/2014)... 19, 2014  An entire month is dedicated to ... – Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular disease ... muscle atrophy, weakness, and foot and hand deformities. CMT ... worldwide. CMT is a progressive disease, and over time ... mobility devices such as leg braces, wheelchairs and scooters ...
Breaking Biology Technology:Chemistry for Global Development during the Open Access Week 2Chemistry for Global Development during the Open Access Week 3World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2
... have a penchant for the CSI side of project management ... calls suggesting a spinoff. "CSI: Project Management" has such a ... recently is the flurry of news about Acela, the fast ... the story, cracks have developed in the disc brakes and ...
... some of the same technology used by Internet search engines ... crowded. , ,The University of Wisconsin-Madison E-Business Consortium ... efficiency, security and enterprise readiness in a recently published ... overall winner, ceding ground only in security to ...
... effective and proper networking techniques, you may not be maximizing ... other professionals. While people have their own networking style that ... ,You need to do what works best for you and ... learn new ideas about networking from other professionals who have ...
Cached Biology Technology:When innovation gets off track 2When innovation gets off track 3Improve your networking skills by learning from other professionals 2Improve your networking skills by learning from other professionals 3Improve your networking skills by learning from other professionals 4
... ester can be used to ... The covalently bound acridinium NHS ... the presence of hydrogen peroxide. ... be used as a detection ...
... designed to hold up to 6 strain chambers ... easy to use design ensures that cells grow ... stretching or compression. This unit allows you to ... to produce 64 unique strain settings. The instrument ...
... Kit delivers a novel procedure for the ... of whole genome DNA from small samples. ... a quick and highly reproducible amplification and ... of a REPLI-g Mini Kit module (QIAGEN) ...
... delivery using PULSin may be superior to ... unlike traditional transfection, with PULSin you can ... and time course of proteins in cells. ... more information than traditional RNA interference experiments. ...
Biology Products: