Navigation Links
Old drug, new tricks: Prospects for slashing the impact of malaria

A dramatic reduction in the impact of malaria is in prospect with a clinical drug trial to begin in Papua New Guinea early next year. Success in the trial would open the way to relief in the 10% of humanity infected with this debilitating and often fatal disease - over 500,000,000 people.

The Walter and Eliza Hall Institute of Medical Research is collaborating with the Papua New Guinea Institute of Medical Research (PNGIMR) and the University of Melbourne to confirm significant health benefits in the new application of an old malaria drug - at just 12 cents a dose. The project is supported by a AUD$3. 7 million grant to PNGIMR from the Bill and Melinda Gates Foundation.

Fansidar is a 20-year-old malaria drug. As with many other such curative drugs, its effectiveness has declined over time with increased resistance by the malaria parasite. But initial clinical evidence suggests that Fansidar could have a new lease on life as a protective drug that strengthens a person's own immune system against malaria.

Early field experiments were conducted in the African country of Tanzania in the late 1990s. These suggested that giving just one Fansidar tablet to an apparently healthy child during their routine infant immunization visits dramatically reduced the impact of any subsequent malaria infection. Used in this way, Fansidar does not prevent malaria but seems to produce a massive 50% reduction in death, debilitation and complications of malaria, such as severe anaemia and raging fevers.

Joint project leader, Dr Louis Schofield from WEHI, says, "There seems to be a totally unexpected residual immunological effect when children are given this tablet as a preventative rather than as a post-infection treatment for malaria. While the drug itself dissipates in the bloodstream over a few days, it appears to enable the immune system to re-energize and more successfully combat any subsequent malarial infection. We suspect that many toddlers who se
'"/>

Source:Research Australia


Page: 1 2

Related biology news :

1. Researchers reveal the infectious impact of salmon farms on wild salmon
2. Measuring the impact of post-genomics on Mediterranean populations
3. Second messenger NAADP shows fast, dose-related impact on satiety cycle
4. The first impact factor for PLoS Biology ?13.9
5. Open Access journals get impressive impact factors
6. OHSU research shows vitamin C counteracts some negative impacts of smoking on unborn babies
7. York scientists warn of dramatic impact of climate change on Africa
8. Breath of the dragon: ERS-2 and Envisat reveal impact of economic growth on Chinas air quality
9. Amazon trees much older than assumed, raising questions on global climate impact of region
10. Health of Acehnese reefs in the wake of the tsunami shows human impacts more harmful
11. Infused spleen cells found not to impact islet recovery and reversal of type 1 diabetes in mice
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Old drug new tricks Prospects for slashing the impact malaria

(Date:9/2/2014)... MD - The American Society of Human Genetics ... (NHGRI), part of the National Institutes of Health, ... at Northwestern University in Chicago, the newest ASHG/NHGRI ... begins today. , The Genetics and Public Policy ... develop and implement genetics-related health and research policy ...
(Date:9/2/2014)... PARK, Md. -- A team of University of ... they and other scientists say make possible new ... from clean energy and quantum computing advances to ... 2, issue of Nature Communications the ... synthesis strategy for hybrid nanostructures that uses a ...
(Date:9/2/2014)... [Brown University] It,s hard to comprehend how bad ... has become without knowing what it was before people ... rate was 10 times lower than scientists had thought, ... worse. , Extinctions are about 1,000 times more frequent ... came along. The explanation from lead author Jurriaan de ...
Breaking Biology News(10 mins):ASHG and NHGRI award genetics and public policy fellowship 2New synthesis method may shape future of nanostructures, clean energy 2New synthesis method may shape future of nanostructures, clean energy 3Extinctions during human era worse than thought 2Extinctions during human era worse than thought 3
... The Scripps Research Institute (TSRI) and the Takeda ... research collaboration to search for new drug targets for ... an initial collaboration launched in 2010 between scientists on ... led to several breakthroughs in identifying potential new compounds ...
... release is available in French . ... Sciences and his colleagues have unearthed a major scientific discovery ... Shale fossil beds, located in Yoho National Park. The fossils ... 505 million years old., Their study, to be published online ...
... March 13, 2013 Even after researchers studying White Nose ... is at the heart of the devastating disease, detecting ... This month, the journal Mycologia will publish research ... identifying additional species of Geomyces and describing development ...
Cached Biology News:Scripps Research and Takeda Pharmaceuticals announce expanded research collaboration 2Strange phallus-shaped creature provides crucial missing link 2More accurate, sensitive DNA test allows early identification of fungus causing WNS 2
(Date:9/2/2014)... NEW YORK , September 2, 2014 ... Market Study on Membrane Technology in Pharmaceutical, Biopharma and ... Witness Highest Growth by 2019" the global membrane technology market for ... 7,029.9 million in 2014 and is expected to grow ... to reach an estimated value of USD 10,886.0 million ...
(Date:9/2/2014)... Opertech Bio, Inc., a company that ... approach to sensory evaluation, today announced the issuance ... Patent and Trademark Office, encompassing high-throughput sensory discrimination ... taste evaluation technology called Microtiter Operant Gustometer or ... for rapid characterization of taste sensory properties,” said ...
(Date:9/2/2014)... 2014  Synthetic Biologics, Inc. (NYSE MKT: SYN), ... candidates targeting specific pathogens that cause serious infections ... final preclinical toxicology study of SYN-004. Per U.S. ... study was required to move the Company,s lead ... devastating effects of Clostridium difficile (C. difficile), ...
(Date:9/2/2014)... September 2, 2014 Culot brings ... and lab management services  BioData, producer of ... pleased to announce the appointment of Louis Culot ... served as VP Marketing and Business Development at BioDiscovery ... and clinical applications. Previously, Culot worked for ...
Breaking Biology Technology:Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 2Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 3Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 4Global Membrane Technology Market Will Reach $10,886.0 Million in 2019: Persistence Market Research 5Opertech Bio Receives U.S. Patent for High-Throughput Taste Evaluation Technology 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5Louis Culot Appointed as BioData's CEO 2
... 6 Today, Pepscan reports,that it has achieved ... its,CLIPS-based synthetic peptide immunogen technology. By constructing synthetic,3D ... has induced functional,antibodies against the formerly intractable GPCR ... be involved in tumor angiogenesis. , ...
... today a strategic partnership with Scottsdale Clinical Research Institute ... cutting edge knowledge discovery and collaboration tools at ... more access to the latest therapies to treat cancer ... and communicate with each other about difficult cases. ...
... Communications Solution Demonstrated at HIMSS 2009BERKELEY HEIGHTS, N.J., ... (Nasdaq: ADAT ), a worldwide provider ... services, today announced that it has integrated Authentidate,s ... to improve hospital patient discharges. "Hospitals are looking ...
Cached Biology Technology:Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7 2MedTrust Online and Scottsdale Clinical Research Institute at Scottsdale Healthcare Announce Collaboration to Provide Cutting Edge Technology to Improve Patient Care 2Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes 2Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes 3Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes 4
EGTA, 10 g. Ethylene glycol-O,O-bis-[2-amino-ethyl]-N,N,N,N,-tetraacetic acid.Assay: > 99.0%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
...
RABBIT ANTI D-TYROSINE CONJUGATE...
... PCR Spots, Oligo Spots and complementary RNA ... microarray experiments. Use for glass array printing ... for reverse transcription, cDNA labeling, hybridization stringency ... Control PCR Spots and Oligo Spots, ...
Biology Products: