Navigation Links
Oh, rats! Designer animals reveal possible heart disease genes

Every year, heart disease claims an estimated 7 million lives, according to the World Health Organization. Scientists have struggled to pinpoint the precise genes behind this complex disease. Now, however, they have a new research ally: the designer rat.

In a four-year study published in the January 15 advance online publication of Nature Genetics, researchers at The Institute for Genomic Research (TIGR) and the Medical College of Wisconsin (MCW) systematically bred and studied 43 designer rats with and without high blood pressure, in order to pinpoint candidate genes behind heart disease. In total, the scientists built 2,200 microarray gene expression profiles from these designer rats--providing a valuable new online resource now available to researchers worldwide.

Scientists have long used rat models to study heart disease in the lab. But those studies have yet to answer key questions: Which genes, on which chromosomes, combine to cause this complex condition? Why, and how, do some animals become hypertensive when consuming high-salt diets, while others stay healthy? To turn the tools of genomics onto these questions, the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, funded the new study.

In the first part of the study, MCW researchers began with a strain of rats bearing high blood pressure, a hallmark of heart disease. The researchers then bred an almost identical designer rat, with one important change: they substituted one chromosome from the parental, hypertensive rat with the homologous chromosome from a healthy rat. Continuing this way, the team generated 22 unique designer rat strains, each bearing one distinct healthy chromosome substitution. Some of these new designer rats were disease-free, implying that their replaced chromosomes carried genes for high blood pressure and related conditions.

In the second part of the study, TIGR molecular biologist Norman Lee led the team in using a DNA microarray technique to compare the expression of more than 22,000 genes among the hypertensive, healthy, and designer rats. By studying the physical characteristics and gene expression of more than 800 rats, the team identified candidate genes that may contribute to cardiovascular disease, including some genes not previously associated with the condition.

"This information offers an unprecedented amount of data for cardiovascular researchers to now mine," remarks Lee, senior author of the study. Lead author Renae Malek, also a molecular biologist at TIGR, notes that the data point to promising genes for salt-sensitive hypertension, among other conditions. The online database resulting from the study, dubbed TREX, is available free of charge at: http://pga.tigr.org/.

TIGR continues to study the panels of designer rat strains, and Lee hopes in the future to knock out specific candidate heart disease genes, directly testing their effects. "With all this information in hand, science is moving from a microscopic to global perspective of heart disease," Lee says. "This will generate research projects for years down the line."


'"/>

Source:The Institute for Genomic Research


Related biology news :

1. Designer babies - what would you do for a healthy baby?
2. Plants, animals share molecular growth mechanisms
3. Elephants imitate truck noises, other animals
4. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
5. Gene therapy for Parkinsons disease moves forward in animals
6. Use of PET can reduce, may eliminate more strenuous drug development trials with animals
7. Undesirable expatriates: Preventing the spread of invasive animals
8. Two new retroviruses—transmitted from animals—identified
9. Stem cell therapy successfully treats heart attack in animals
10. More animals join the learning circle
11. Proposal would allow wild animals to roam North America
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/19/2017)... , April 19, 2017 The ... vendor landscape is marked by the presence of several ... however held by five major players - 3M Cogent, ... companies accounted for nearly 61% of the global military ... companies in the global military biometrics market boast global ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... For ... has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled ... Volunteer Experience from US2020. , US2020’s mission is to change the trajectory of ...
(Date:10/10/2017)... ... 2017 , ... The Pittcon Program Committee is pleased to ... who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award ... conference and exposition for laboratory science, which will be held February 26-March 1, ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography ... generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial for glioblastoma ... Cancer Institute. The event is free and open to the public, but registration ...
Breaking Biology Technology: