Navigation Links
OHSU study says stem cell 'fusion' occurs in tumors

ying molecular explanation of why these cells might be more susceptible to cancer development."

In the PNAS study, Wong and her colleagues transplanted bone marrow cells from female mice into a male mouse model of intestinal cancer. The donor-derived cells were readily detected in the intestinal tumors of the male mice.

To show that the transplanted donor cells fused with the tumor cells, the scientists detected proteins or markers from both the female donor and male recipient cells in tumors. The only way both donor and recipient markers could be present in a single cell, or colocalized, would be if the two cells fused.

One test to prove cell fusion involved looking for the presence of Y chromosomes, or male-characteristic DNA, within the female donor cells marked with a green fluorescent protein. About 60 percent of the epithelial cells were positive for both donor and recipient cell markers. A second test confirmed colocalization using a confocal microscope, which can scan a single cell layer of intestinal cells for the presence of both the green fluorescent protein, indicating female donor cells, and an enzyme from the male recipient cells

Wong said, "Our paper is unique because it's the first example that cell fusion occurs in the epithelial compartment of a tumor."

Other OHSU studies in recent years are giving weight to the fusion theory. A series of discoveries since 2000 by study co-author Markus Grompe, M.D., professor of molecular and medical genetics, and pediatrics, OHSU School of Medicine, and director of OHSU's Oregon Stem Cell Center, showed that blood-forming stem cells derived from bone marrow, called hematopoietic stem cells, cure liver disease in mice through cell fusion rather than transdifferentiation of the transplanted stem cells.

Wong acknowledges fusion is still a new concept. But it's gaining popularity as a way of explaining the molecular mechanisms that may be at work in regenerating rapidly
'"/>

Source:Oregon Health & Science University


Page: 1 2 3

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: OHSU study says stem cell fusion occurs tumors

(Date:9/18/2014)... the ultimate form of camouflage: you don,t just blend ... is not as uncommon as you might think. Kathryn ... explains that the larval life stages of many marine ... the anatomy that most creatures cannot make transparent. Feller ... shield each individual eye unit with an opaque pigment ...
(Date:9/17/2014)... Penn State,s Institute for the Arts and Humanities has ... Foundation for a two-year project, "The Boundaries of the ... The project will support a wide-ranging series of events ... and humanities. One involves artists and researchers who are ... and the idea of humanism, and the other involves ...
(Date:9/17/2014)... against disposable plastic shopping bags and their environmental impact ... passed the first statewide ban on the bags, and ... the plastic bag industry is not yielding without a ... Engineering News , the weekly newsmagazine of the American ... C&EN, reports that the anti-bag campaign logged its first ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2Mellon Foundation awards grant for major project in the humanities and sciences 2
... NOVEMBER 16, 2009 Experts in soil science and representatives ... Congressional educational briefing, "The Essence of Earth and Wine: Terroir" ... House Office Building (Gold Room). Experts in ... -- how the balance of vineyard management and soil site ...
... mind sharing space with their kin but when they,re potted ... leaves, a study by McMaster University reveals. The research, ... Journal of Botany , suggests non-kin plants will not only ... out the competition above ground in the ongoing struggle for ...
... dioxide (TiO2) nanoparticles, found in everything from cosmetics to ... in mice, according to a comprehensive study conducted by ... TiO2 nanoparticles induced single- and double-strand DNA breaks and ... of which increase the risk for cancer. The UCLA ...
Cached Biology News:Soil experts to discuss terroir, the link between Earth, wine on Nov. 19 in DC 2Plants prefer their kin, but crowd out competition when sharing a pot with strangers 2Nanoparticles used in common household items caused genetic damage in mice 2Nanoparticles used in common household items caused genetic damage in mice 3
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global and Chinese Stem Cell Industry Report, 2014-2017" ... are undifferentiated biological cells that can differentiate into specialized ... stem cells. Stem cell therapy can be applied to ... system disease), nervous system diseases, damage or lesion of ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global Human Albumin Industry Report 2014" report ... Albumin Industry Report 2014 is a professional and in-depth ... albumin industry. The report provides a basic ... industry chain structure. The human albumin market analysis is ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Leatherwood ... FM-4910 listed material, to stay competitive in the ... These high-performance materials ultimately impact product quality and ... and owner. , Established in 1980 in Lewisville, ... as many fabricators have left the business. Much ...
(Date:9/18/2014)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology ... cancer, announced today that Daniel P. Gold , Ph.D., ... NewsMakers in the Biotech Industry conference on Friday, September ... Broadway Hotel & Conference Center in New York ... accessed at www.meipharma.com . A replay will be available ...
Breaking Biology Technology:Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 3
... DNA polymerase , makes hot start simple and efficient , , ... , , , Jonathan Eads Frances Bai Ronda ... Stratagene , , , ... Taq , DNA polymerase , is ...
... ,,,, Stable reporter cell lines for signal transduction ... Li Xu Alan Greener Mary Buchanan ,John ... the PathDetect ,HLR-CREB, HLR-Elk1, and ... signal transduction pathways that converge at the transcription,factors CREB, ...
... minutes , Weiping Yang Matt C. ... Cloning Systems, Inc. , Stratagenes IsoDetect mouse monoclonal ... method for identifying mouse monoclonal antibody,isotypes in a ... self-contained assay,using colloidal gold-conjugated anti-mouse antibodies for isotype ...
Cached Biology Technology:Greater Amplification Specificity with New Hot Start PCR Enzyme 2Greater Amplification Specificity with New Hot Start PCR Enzyme 3Greater Amplification Specificity with New Hot Start PCR Enzyme 4Greater Amplification Specificity with New Hot Start PCR Enzyme 5Greater Amplification Specificity with New Hot Start PCR Enzyme 6Greater Amplification Specificity with New Hot Start PCR Enzyme 7Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 2Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 3Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 4Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 5Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 6Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 2Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 3Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 4Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies 5