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OHSU researchers demonstrate how white blood cells cannibalize virus-infected cells

Researchers at the Vaccine and Gene Therapy Institute (VGTI) at Oregon Health & Science University have demonstrated how certain white blood cells literally eat virus-infected cells while fighting disease at the microscopic level. The research not only helps provide a clearer understanding of the body's immune system, it also offers hope of a new method for gauging vaccine effectiveness. The research is published in the current edition of the journal Nature Medicine.

CD8+ T-cells are specialized white blood cells that serve an important role in the body's immune system. The cells attack and destroy disease "invaders" such as viruses in the body. Previous studies indicated that T-cells may consume parts of cells with which they interact, but this new research shows this can happen in response to a systemic viral infection.

"If you use a fluorescent dye to stain infected cells, you can literally watch T-cells consume membranes and outer surfaces of diseased cells. As they destroy and cannibalize the fluorescently labeled cells, they become labeled with the fluorescent dye themselves," explained Mark Slifka, Ph.D., a researcher in the VGTI who led the research. Slifka is also a scientist in the Division of Pathobiology and Immunology at the Oregon National Primate Research Center and holds a concurrent appointment in the Department of Molecular Microbiology and Immunology in the OHSU School of Medicine.

"While we don't fully understand why this happens, one possibility is that the T-cell consumes virus-infected cells to fuel itself in the continued fight against an ongoing infection. It's sort of like invaders that pillage their defeated foe's supplies and then continue the fight."

The way in which Slifka and his colleague, Carol Beadling, made this discovery was quite serendipitous. The researchers were studying the interactions between virus-specific T-cells and fluorescently labeled infected cells when they noticed that the T-ce
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Source:Oregon Health & Science University


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