Navigation Links
OHSU researchers demonstrate how white blood cells cannibalize virus-infected cells

Researchers at the Vaccine and Gene Therapy Institute (VGTI) at Oregon Health & Science University have demonstrated how certain white blood cells literally eat virus-infected cells while fighting disease at the microscopic level. The research not only helps provide a clearer understanding of the body's immune system, it also offers hope of a new method for gauging vaccine effectiveness. The research is published in the current edition of the journal Nature Medicine.

CD8+ T-cells are specialized white blood cells that serve an important role in the body's immune system. The cells attack and destroy disease "invaders" such as viruses in the body. Previous studies indicated that T-cells may consume parts of cells with which they interact, but this new research shows this can happen in response to a systemic viral infection.

"If you use a fluorescent dye to stain infected cells, you can literally watch T-cells consume membranes and outer surfaces of diseased cells. As they destroy and cannibalize the fluorescently labeled cells, they become labeled with the fluorescent dye themselves," explained Mark Slifka, Ph.D., a researcher in the VGTI who led the research. Slifka is also a scientist in the Division of Pathobiology and Immunology at the Oregon National Primate Research Center and holds a concurrent appointment in the Department of Molecular Microbiology and Immunology in the OHSU School of Medicine.

"While we don't fully understand why this happens, one possibility is that the T-cell consumes virus-infected cells to fuel itself in the continued fight against an ongoing infection. It's sort of like invaders that pillage their defeated foe's supplies and then continue the fight."

The way in which Slifka and his colleague, Carol Beadling, made this discovery was quite serendipitous. The researchers were studying the interactions between virus-specific T-cells and fluorescently labeled infected cells when they noticed that the T-ce lls also began to glow with the fluorescent dye. Further investigation revealed that the CD8+ T-cells, often referred to as "killer" T-cells, were literally ingesting parts of the virus-infected cells that they were attacking.

Slifka and Beadling's findings follow a discovery by David Parker, Ph.D., a professor of Molecular Microbiology and Immunology in the OHSU School of Medicine. Parker and his colleague, Scott Wetzel, noted a similar behavior in CD4+ T-cells, often called "helper" T-cells, which are less aggressive T-cells but also an important aspect of the immune system.

"Another interesting finding for our lab is that in some ways, T-cells can be picky eaters," explained Slifka. "Although they will destroy almost any infected cell, they prefer to eat certain types of cells but not others. For instance, we noted that CD8+ T-cells consumed other white blood cells such as infected B-cells, but they were not fond of eating infected fibroblasts, a type of cell found in connective tissue. They're sort of like a 5-year-old who loves to eat cookies, but refuses to eat their brussels sprouts."

The researchers believe that these findings may be useful as a method for determining a vaccine's effectiveness during the process of immunization. Measuring the levels at which CD8+ T-cells respond to and consume a candidate vaccine could likely determine whether that vaccine is effective in educating the body's immune system as to what diseases to look for.


'"/>

Source:Oregon Health & Science University


Related biology news :

1. NYU researchers simulate molecular biological clock
2. Vital step in cellular migration described by UCSD medical researchers
3. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
4. UCSD researchers maintain stem cells without contaminated animal feeder layers
5. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
6. New protein discovered by Hebrew University researchers
7. First real-time view of developing neurons reveals surprises, say Stanford researchers
8. Agilent Technologies releases automated literature search tool for biology researchers
9. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. US life expectancy about to decline, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2016)... , Jan. 20, 2016  Synaptics Incorporated ... human interface solutions, today announced sampling of S1423, ... for wearables and small screen applications including smartwatches, ... printers. Supporting round and rectangular shapes, as well ... excellent performance with moisture on screen, while wearing ...
(Date:1/15/2016)... Rico , Jan. 15, 2016 Recent ... and small to find new ways to ensure data ... iOS and Android that ... on biometrics, transforming it into a hardware authorization token. ... users swipe their fingerprint on their KodeKey enabled device ...
(Date:1/13/2016)... , January 13, 2016 ... the addition of the  "India Biometrics ... & Forecast (2015-2020)"  report to ... ) has announced the addition of ... Market - Estimation & Forecast (2015-2020)" ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... 2016  PTC Therapeutics, Inc. (NASDAQ: PTCT ... to Realize Innovation, Vision and Empowerment) grant award ... funds to patient advocacy organizations to develop unique ... to the rare disease community by increasing awareness, ... advocates. Mary Frances Harmon , ...
(Date:2/11/2016)... -- Neurocrine Biosciences, Inc. (NASDAQ: NBIX ) today announced its financial ... --> --> For the fourth ... million, or $0.34 loss per share, compared to a net loss ... period in 2014. For the year ended December 31, 2015, the ... per share, as compared to a net loss of $60.5 million, ...
(Date:2/11/2016)... YORK , Feb. 11, 2016  Bioethics International, a ... medicines are researched, developed, marketed and made accessible to patients ... BMJ Open had named the publication of the ... 2015. The publication is also featured as one of ... in the last year that are most frequently read. ...
(Date:2/11/2016)... NY (PRWEB) , ... February ... ... a business-to-business publication dedicated to delivering cutting-edge information focused on the development ... Life Sciences to become a premier sponsor of the 2016 BioProcess International ...
Breaking Biology Technology: