Navigation Links
OHSU discovery sheds light into how stem cells become brain cells

Researchers at the Oregon National Primate Research Center at Oregon Health & Science University (OHSU) have discovered one key gene that appears to control how stem cells become various kinds of brain cells. The finding has significant implications for the study of Parkinson's disease, brain and spinal cord injury, and other conditions or diseases that might be combated by replacing lost or damaged brain cells. The research is published in the current online edition of the medical journal Developmental Biology.

"In the early stages of brain development prior to birth, brain stem cells, also known as neural stem cells, will differentiate into neurons," explained Larry Sherman, Ph.D., an associate scientist in the Division of Neuroscience at the Oregon National Primate Research Center and an adjunct associate professor of cell and developmental biology in the OHSU School of Medicine. "In later stages, these same stem cells suddenly start becoming glial cells, which perform a number of functions that include supporting the neurons. We wanted to find out what factors cause this switch in differentiation. We also wanted to determine if the process can be controlled and used as a possible therapy. What amazed us is that it turns out a single gene may be responsible for this incredibly important task."

The key gene that the scientists studied is called brahma-related gene-1 (Brg-1) that is found in both mice and humans. This protein had been previously studied extensively in human cancers, but not in the nervous system. To determine the precise role of Brg-1, Sherman, in collaboration with Dr. Steven Matsumoto from the Integrative Biosciences Department at the OHSU School of Dentistry, bred mice lacking the gene in the nervous system. This resulted in the development of embryos with smaller brains containing neurons but virtually no glial cells. When they isolated neural stem cells, placed them into cell culture and then removed Brg1, the cells in the c
'"/>

Source:Oregon Health & Science University


Page: 1 2

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Purdue proves concept of using nano-materials for drug discovery
3. UCSD discovery may help extend life of natural pesticide
4. Leprosy microbes lead scientists to immune discovery
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. Researchers make surprise discovery that some neurons can transmit three signals at once
7. Important discovery about second most fatal cancer
8. Harmless virus may hold key to more effective HIV drug discovery
9. Fundamental discovery -- Bone fracture
10. Genetic discovery could lead to drought-resistant plants
11. Gene discovery sheds light on causes of rare disease, cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: OHSU discovery sheds light into how stem cells become brain cells

(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... nominated for the 2015 New York Design Awards under ... Design100, New York City Design Awards are part of ... on over 2,500 ratings from the marketplace, industry and ...
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... revealed what may well be the first pervasive rule ... the Proceedings of the National Academy of Sciences researchers ... to become increasingly more complex. Looking back ... catalogue to the present day, the team investigated the ...
... not only smart, but they also wage a good ... studies have shown that plants can sense attacks by ... been known what happens between the pathogen attacks and ... revealed a very complex process that explains how plants ...
... holds three patents in the emerging field of nanotechnology ... the technology,s potential in materials science and medicine. ... a strong call for exploring potential environmental and health ... designing new materials with reduced hazard. The available data, ...
Cached Biology News:First 'rule' of evolution suggests that life is destined to become more complex 2Researcher discovers pathway plants use to fight back against pathogens 2Think green, UO's Hutchison says, to reduce nanotech hazards 2Think green, UO's Hutchison says, to reduce nanotech hazards 3
(Date:5/6/2015)... Atlanta, GA (PRWEB) May 06, 2015 ... solutions based on the products of cells grown ... on its 105F immunomodulatory treatment candidate for melanoma ... Annual Meeting, taking place May 6-9, 2015 in ... hypoxia-induced multipotent cells produce a soluble material with ...
(Date:5/5/2015)... 2015  Blueprint Medicines (NASDAQ: BPMC ) ... offering of 9,367,708 shares of common stock at ... including shares of common stock issued upon the ... to purchase additional shares. The gross proceeds from ... approximately $168.6 million, before underwriting discounts and estimated offering ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 VetStem ... Science Animal Health, Jeffrey Schaffer, DVM, as Director ... over 15 years of experience in the veterinary ... great addition to our veterinarian lead organization”. ... explains. “Dr. Schaffer will be responsible for all ...
(Date:5/5/2015)... , May 5, 2015  Tikcro Technologies Ltd. ... approved to continue trading on OTCQB  Marketplace, the ... OTCQB Marketplace allows for a continuous public market ... can have real-time quotes and market information on ... The OTCQB Marketplace includes U.S. and international companies ...
Breaking Biology Technology:Novel Immunomodulatory Treatment Induces Apoptosis in Melanoma 2Blueprint Medicines Announces Closing of Initial Public Offering 2Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2
... for 2004 and what impact will these have on the future? ... land of biotech and pharmaceuticals, the answer could be: , , ... side effects and the resultant scrutiny on the FDA for not ... way, the recent Pfizer debacle with Celebrex in the last two ...
... Philip M. Farrell The University of Wisconsin Medical Schools ... office at the end of 2005 to go back to ... pulmonologist whose studies focus on cystic fibrosis, an inherited condition ... continued this research while a dean, making advances such as ...
... are ripe for prognostication and this one is no different. ... technology industry has been laboring up, up, up the steep incline ... a bit of payback, a little joy ride. And to be ... playful loops, not the white-knuckled death plummet we have not yet ...
Cached Biology Technology:The greatest life-science developments of 2004 2The greatest life-science developments of 2004 3The greatest life-science developments of 2004 4The greatest life-science developments of 2004 5The greatest life-science developments of 2004 6The greatest life-science developments of 2004 7Year ahead offers payoff for hard work 2Year ahead offers payoff for hard work 3
Synphilin 1 Immunogen: Synthetic peptide corresponding to residues S(829) L E L N G E K D K D K G R T L Q R T(847) of human Synphilin 1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
KAI 1 (G-2)...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
Biology Products: