Navigation Links
Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

To investigate tumors, pathologists currently rely on labor-intensive microscopic examination, using century-old cell-staining methods that can take days to complete and may give false readings.

A lightning-fast laser technique, led by Sandia National Laboratories researcher Paul Gourley, has provided laboratory demonstrations of accurate, real-time, high-throughput identification of liver tumor cells at their earliest stages, and without invasive chemical reagents.

The technique generates a laser beam in single human cells pumped from a flask through tiny microchannels. The beam is altered by what it encounters. These changes, registered by an imaging spectrometer, instantly identify cancer-modified mitochondria in cells gone wrong. Mitochondria are known as the power pack of cells, energizing them like batteries do flashlight bulbs.

"There are hundreds of mitochondria, sometimes thousands, in a cell," says Gourley. "To see them in the old way requires a time-consuming process like fluorescent tagging or a chemical reagent. We've found we can see them immediately by light alone."

The techniques could be critical to advancing early detection, diagnosis, and treatment of disease.

More technically put, "To rapidly assess the health of a single mammalian cell," says Gourley, "the key discovery was the elucidation of biophotonic differences in normal and cancer cells by using intracellular mitochondria as biomarkers for disease. This technique holds promise for detecting cancer at a very early stage and could nearly eliminate delays in diagnosis and treatment."

The technique is effective because "it measures changes in the cell architecture, especially those arising from alterations in protein density, cytoskeleton shape, and distribution of mitochondria - changes that occur when a cell becomes cancerous," says Gourley.

"One would think that if a cell became nonfunctional, it would become disorganized. In cancer, ho
'"/>

Source:DOE/Sandia National Laboratories


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel antiviral technology inhibits RSV infection in mice
4. Novel Enzyme Shows Potential As An Anti-HIV Target
5. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
6. Discovery Could Lead To Novel Approaches In HIV Treatment
7. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
8. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
9. Novel live reporting system to track cells
10. Field of beams - Novel system uses polarized light pulses to reveal crop health
11. Novel compounds show promise as safer, more potent insecticides
Post Your Comments:
(Date:1/22/2015)... Technology Showcase, Hall E -   EyeLock Inc. , ... it will showcase its EyeLock ID technology integrated in a ... Energy,s Oak Ridge National Laboratory (ORNL) at the ... identity authentication technology is being used to validate the driver ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric ... recent success of the Wocket™ smart wallet at CES 2015 in ... named as one of the "11 Hot Products at CES" in a ... CES So Far" by Newseveryday.com and "The top 10 gadgets from CES ...
(Date:1/22/2015)... , Europe,s most prestigious innovation prize ... present a video retrospective of the most exciting and innovative nominations  ... and Sophie Wilson   A different theme ... Starting on 22 January 2015 on   http://www.epo.org/european-inventor   ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... Palais des congrs de Montral, Montral, Qubec, Canada, 22-26 July ... -- The Society for the Study of Reproduction (SSR) ... 46th SSR Annual Meeting to be held in Montral, Qubec, ... page ( http://www.ssr.org/Meetings.shtml ) for details; information will be added ...
... known that animals flourish in regions where the climate ... set out to discover whether that same relationship held ... when dinosaurs roamed the Earth. "The assumption has ... ecosystems," said paleontologist and lead author Timothy S. Myers, ...
... Noah got it wrong? What if he paired a male ... and then discovered they were not the same and could ... Rescue and Conservation Project race to save frogs from a ... averts mating mix-ups., At the El Valle Amphibian Conservation Center, ...
Cached Biology News:Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants 2Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants 3Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants 4
(Date:2/27/2015)... DIEGO , Feb. 27, 2015  Pfenex Inc. ... the development of biosimilar therapeutics, today announced that it ... Francisco Marriott Marquis on March 2 nd at ... participate on a panel discussing the current state of ... of Biosimilars . For more information ...
(Date:2/27/2015)... 27, 2015  Steep Hill, the industry leader in ... intends to open a full service medical cannabis quality ... , bringing advanced scientific tools and methodology to the ... Hill is currently the only laboratory licensed by the ... contaminant testing in order to meet the recently adopted ...
(Date:2/26/2015)... On behalf of biotech client GenScript ... Goldman & Spitzer, P.A. (Wilentz) secured a significant jury ... in excess of $10 million. The jury determined that ... that it improperly hired one or more of GenScript,s ... judgment notwithstanding the verdict, a new trial, and remittitur. ...
(Date:2/26/2015)... Synageva BioPharma Corp. (NASDAQ: GEVA ... rare disorders, today reported 2014 full year financial ... and financial guidance.  Synageva,s management team will host ... to review the financial results and provide a ... by telephone, please dial (877) 445-4603 for U.S. ...
Breaking Biology Technology:Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9
... June 3, 2011 Asmacure Ltee, a ... receptor agonists for the treatment of asthma and other ... appointed as chief executive officer.  With a solid foundation ... as it progresses its lead compound, a potential new ...
... better predict general patterns of evolution, a University of ... surprising things about gene mutations that might one day ... disease. UH evolutionary biologist Timothy Cooper and ... "Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial ...
... LIVONIA, Mich., June 2, 2011 Genentech and Novartis ... to Market Strategies International, a market research consultancy that ... more than 30 sales force, corporate equity and R&D ... and performance in this rapidly growing marketplace. ...
Cached Biology Technology:Asmacure Ltee Appoints Pharmaceutical and Biotechnology Industry Veteran Martin Driscoll as CEO 2Asmacure Ltee Appoints Pharmaceutical and Biotechnology Industry Veteran Martin Driscoll as CEO 3Work by UH evolutionary biologist may one day help with chronic diseases 2Genentech and Novartis Remain Image Leaders in Oncology and Hematology 2Genentech and Novartis Remain Image Leaders in Oncology and Hematology 3
... NAP-10 Columns, 50. For rapid and efficient ... in less than 15 minutes by gravity ... distilled water containing 0.15% Kathon CG/ICP Biocide.Available ... 0.5 ml (NAP-5), 1 ml (NAP-10) ...
Human ROR1 Affinity Purified Polyclonal Ab...
Human Rad1 MAb (Clone 33)...
Recombinant Ovine (Sheep) Growth Hormone, Ultra Pure...
Biology Products: