Navigation Links
Novel therapy combinations gain ground in treating hepatitis

ies which will evaluate the ability of VX-950 to produce sustained viral responses with as little as 12 weeks of therapy." VX-950 + pegIFN + RBV was well tolerated, with no serious adverse events and no treatment discontinuations. A detailed analysis of adverse events will be presented.

Acetaminophen as a co-factor in acute liver failure due to viral hepatitis determined by measurement of acetaminophen-protein adducts [Abstract S1002]

Acetaminophen (APAP) is a common over-the-counter medication present in more than 300 preparations for pain relief and flu-like symptoms. But for people who are suffering from viral hepatitis A or B, use of acetaminophen may play a role in accelerating liver failure, ordinarily a rare complication of viral hepatitis.

Serum samples from 72 patients with proven hepatitis A or B that had progressed to liver failure were tested for APAP adducts, which are the toxic byproducts of acetaminophen liver damage, created when a chemical (in this case, acetaminophen) binds to proteins in the liver that are then released into the blood when cells die. As a positive control group, the team also included 10 documented cases of acute liver failure (ALF) resulting directly from large APAP overdoses.

Results from the examination showed that nine of the 72 patients (12.5 percent) had detectable APAP adducts in their blood, signifying that some of their liver damage was APAP-related. All 10 known APAP-induced ALF cases had positive adducts at much higher levels than those in the viral hepatitis group (average level of 5.58 nmol/mL versus 0.45 nmol/mL, respectively). Two-thirds (67 percent) of the hepatitis patients with APAP adducts died within three weeks of study admission, compared to only 27 percent of hepatitis patients without adducts.

Most of the patients with adducts reported some APAP use in the days prior to the study, but none reported doses exceeding four grams per day. Flu-like symptoms,
'"/>

Source:American Gastroenterological Association


Page: 1 2 3 4 5 6

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel antiviral technology inhibits RSV infection in mice
4. Novel Enzyme Shows Potential As An Anti-HIV Target
5. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
6. Discovery Could Lead To Novel Approaches In HIV Treatment
7. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
8. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
9. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
10. Novel live reporting system to track cells
11. Field of beams - Novel system uses polarized light pulses to reveal crop health
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel therapy combinations gain ground treating hepatitis

(Date:9/18/2014)... tiny strands of nucleic acid that contain instructions for ... data, our DNA is copied into RNA molecules, which ... in our cells. , Several years ago, scientists ... other known RNAs, this molecule is circular, and was ... has been known about how they are produced. Moreover, ...
(Date:9/18/2014)... from several disciplines will be celebrated tonight at the ... in improving the health of premature infants and in ... The researchers, whose work was supported by the National ... former Atomic Energy Commission, will be honored at a ... A bipartisan group of Members of Congress will be ...
(Date:9/18/2014)... the ideal animal in which to study the genes ... into tens of thousands of freshwater streams and lakes ... adapt to the new environment. , Breeding studies between ... up one of the genes that controls tooth number, ... regulation in a freshwater population is associated with a ...
Breaking Biology News(10 mins):Scientists find how mysterious 'circular RNA' is formed, claim muscular dystrophy link 23rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3
... by a discovery about how chickens regulate their appetites. ... the signals sent from its stomach to its brain that ... Poultry farmers often have to restrict food for chickens ... can overeat, affecting their ability to reproduce. The ...
... has shown that obesity runs in families, and twin studies ... heritability estimates over 50%. 32 genes have been identified as ... genes alone cannot fully explain the high level of heritability ... individual differences in childhood body weight. This has led to ...
... to convention, vegetation, when well-maintained, can lower the rates ... robbery and burglary, in cities, according to a Temple ... Evidence from Philadelphia, PA," published in the journal, ... longstanding principle, particularly in urban planning, that you don,t ...
Cached Biology News:Appetite genes are key to better diets for poultry, study shows 2Study finds strong genetic component to childhood obesity 2Urban vegetation deters crime in Philadelphia 2
(Date:9/18/2014)... Sept. 18, 2014 Research and Markets ... and Chinese Stem Cell Industry Report, 2014-2017" report ... undifferentiated biological cells that can differentiate into specialized cells ... cells. Stem cell therapy can be applied to treatment ... disease), nervous system diseases, damage or lesion of liver, ...
(Date:9/18/2014)... , Sept. 18, 2014 Research and ... "Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) ... to their offering. The global companion ... of 22.7% from 2014 to 2019. Factors such as ... adoption of companion diagnostics by the pharmaceutical industry, support ...
(Date:9/18/2014)... DIEGO , Sept. 18, 2014  MEI Pharma, Inc. ... the clinical development of novel therapies for cancer, announced today ... Executive Officer, will present at BioCentury,s NewsMakers in the ... 8:30 a.m. Eastern time from the Millennium Broadway Hotel & ... live webcast of the presentation can be accessed at ...
(Date:9/18/2014)... , Pennsylvanie, 18 septembre 2014 /PRNewswire/ ... en 1974, a été depuis ... compléter les évaluations cliniques traditionnelles par des ... Outcomes) et sur les impacts économiques des ... A cours d,une ...
Breaking Biology Technology:Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3MEI Pharma To Present At BioCentury's NewsMakers Conference 2MEI Pharma To Present At BioCentury's NewsMakers Conference 31974 - 2014 - Mapi fĂȘte ses 40 ans 2
... 2011 United Therapeutics Corporation (NASDAQ: UTHR ... quarter 2011 financial results before market open on Thursday, ... a half-hour teleconference on Thursday, July 28, 2011, at ... dialing 1-877-351-5881, with international callers dialing 1-970-315-0533.  A rebroadcast ...
... N.C. Researchers at Duke University Medical Center have ... Chlamydia , the bacteria responsible for the largest ... The team, which included Duke University microbiologists ... bacteria,s self-defense mechanisms. The therapies that could ...
... RICHMOND, Calif., July 20, 2011 Sangamo BioSciences, Inc. (Nasdaq: ... release its second quarter 2011 financial results on Wednesday, July ... be followed by a conference call at 5:00 p.m. ET, ... webcast. During the conference call, the company will review the ...
Cached Biology Technology:Newly designed molecule blocks chlamydia bacteria 2Newly designed molecule blocks chlamydia bacteria 3Sangamo BioSciences Announces Second Quarter 2011 Conference Call and Webcast 2
... The first SpeedVac to have active, ... Explorer SpeedVac System is the worlds first, ... components can be stacked together to form ... valuable benchspace. It is also the first ...
... RC Standard Bio for vacuum concentrator/centrifugal ... molecular biology and biochemistry for rapid and ... systems can be expanded with pumps, different ... of rotors (eliminating sample loss by transfer), ...
... dedicated concentrator for efficient drying of small ... integrated system combines the SpeedVac™ Concentrator and ... automatic pump and rotor control, and dual ... heater time), makes the DNA120 indispensable in ...
... MB (For small quantities of solvents with ... vacuum concentrator/centrifugal evaporator systems respond to specific ... rapid and safe concentration of heat-labile samples. ... pumps, different of cold traps and a ...
Biology Products: