Navigation Links
Novel therapy combinations gain ground in treating hepatitis

eatment options. Combination treatment using a new antiviral therapy is showing promise in suppressing the virus, according to a phase II US multi-center study. The therapy, valopicitabine, has shown anti-HCV activity alone and in combination with pegIFN (pegylated interferon) in early trials, without viral breakthrough for study periods up to six months.

The current study compared the outcomes of five different treatments in patients who have not experienced remission with standard therapies: valopicitabine alone (800 mg/d), one of three combination arms with the drug at 400 mg/d, 800 mg/d or dose-ramping 400 to 800 mg/d plus pegIFN, or pegIFN with ribavirin as a control group.

For the 162 patients who have completed the trial period at 24 weeks, results show that the two higher-dose combination arms had much better response rates than the control group, experiencing on average a 2.5 to 3.0 log decrease in hepatitis RNA reductions by week 24, a significantly better response than the comparator. No viral breakthrough has been seen to date. However, vomiting and dehydration requiring hospitalization occurred in three patients taking the highest dose (800 mg), forcing the research team to halt the use of that dose and continue using only the lower doses of 200 to 400 mg of the drug.

"For patients whose disease has not responded to current therapies, this new combination treatment may produce excellent results, at the maximally acceptable dosage," according to Paul Pockros, M.D., of Scripps Clinic in California, and lead study author. "Continued treatment will determine if these encouraging early responses will result in a sustained response, hopefully improving patient quality of life and long-term survival."

Comparison of Daily Consensus Interferon versus Peginterferon alfa 2a Extended Therapy of 72 Weeks for Peginterferon / Ribavirin Relapse Patients with Chronic Hepatitis C [Abstract S1060]

In chronic diseases li
'"/>

Source:American Gastroenterological Association


Page: 1 2 3 4 5 6

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel antiviral technology inhibits RSV infection in mice
4. Novel Enzyme Shows Potential As An Anti-HIV Target
5. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
6. Discovery Could Lead To Novel Approaches In HIV Treatment
7. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
8. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
9. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
10. Novel live reporting system to track cells
11. Field of beams - Novel system uses polarized light pulses to reveal crop health
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel therapy combinations gain ground treating hepatitis

(Date:5/22/2013)... genetic engineering drastically reduces the time and effort ... workhorses of biotechnology, scientists are reporting. Published in ... method paves the way for more rapid development ... and other activities. , Keith Shearwin and colleagues ... the genetic material DNA into a bacterium,s genome ...
(Date:5/22/2013)... screening for prostate cancer could become as easy for ... to UC Irvine research published today in the ... more than a decade of work, UC Irvine chemists ... markers for prostate cancer in urine, meaning that the ... and at dramatically lower cost. The same technology could ...
(Date:5/21/2013)... "place" is increasingly being considered in the management ... new resource that can help them recognize and ... places in their lives. , Place-Based Conservation: ... co-edited by the Pacific Northwest Research Station,s Linda ... to conservation. The book is published by Springer ...
Breaking Biology News(10 mins):UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3
... jumps out of the bushes, youre still surprised. But your ... have begun to distinguish the circuitry in the brains emotion ... aversive or reward valence of a stimulus. C. Daniel ... 2007 issue of the journal Neuron, published by Cell Press. ...
... trenches in the First World War, but nearly a century ... discovered that phosgene is present in significant quantities in the ... well after the Second World War, but its continued presence ... used in the chemical industry. A team, including ...
... emissions should quickly reduce mercury levels in lake fish, ... the Proceedings of the National Academy of Science. The ... rates relevant to atmospheric deposition resulted in a significant ... only three years. This is good news. ...
Cached Biology News:How the brain handles surprise, good and bad 2Scientists in first global study of 'poison' gas in the atmosphere 2New study shows fish respond quickly to changes in mercury deposition 2New study shows fish respond quickly to changes in mercury deposition 3
(Date:5/24/2013)... Texas (PRWEB) May 24, 2013 ... benchmarking survey on kinase profiling carried out in ... details of the breakdown of the responses for ... the future (2015). It also highlights some interesting ... survey groupings. Two bottom-up models were developed to ...
(Date:5/24/2013)... Many factors impact tissues targeting such as protein ... the blood-tissue barrier. Even when tissue disposition is achieved, ... tissue rather than the total tissue concentration. , A ... guide lead optimization, predict in vivo activity in animal ... impact the likely human clinical dose. , In this ...
(Date:5/24/2013)... City, OK (PRWEB) May 24, 2013 The ... of casualties. And following its ravage, the mayor of Moore, ... bill for new houses, said a report from cnn.com. Reaching ... the tornado victims complimentary Molderizer and Safe Shield to counter ... to the report published on May 22, 2013, caused 24 ...
(Date:5/24/2013)... Vestiage, Inc. (stock symbol "VEST") a publicly traded ... development, sales and marketing of premium branded highly ... it is awarding exclusive Vestiage territories in the ... Illuminating Facial Care. Qualified applicants can request an ... to info(at)vestiageinc(dot)com and putting RELUMA in the "Subject" ...
Breaking Biology Technology:Kinase Market Profiling - In House & Outsourced Trends 2015 Forecast in New Research Report at ReportsnReports.com 2Kinase Market Profiling - In House & Outsourced Trends 2015 Forecast in New Research Report at ReportsnReports.com 3Kinase Market Profiling - In House & Outsourced Trends 2015 Forecast in New Research Report at ReportsnReports.com 4DMPK for Targeted Tissue Delivery: Solutions for the Most Challenging Part of Outsourcing, New Life Science Webinar Hosted by Xtalks 2Mayor of Oklahoma-Tornado-Impaired Town Proposes Storm Shelter Bill, My Cleaning Products Offers Complimentary Molderizer and Safe Shield to Help Victim with Looming Mold 2Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 2Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 3Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 4Vestiage Announces Launch of Exclusive Territories for Reluma Brand Sales in USA 5
... molecules that appear in the central region of ,macromolecules ... atom ,at their center that determines their specific function. ... molecular electronics lies in their "ease of transfer ,electrons ... the work at the Nanomaterials and Nanotechnology Research Center ...
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today that ... Friday, September 9, 2011 at 10:55 a.m. EDT (7:55 a.m. ... Hotel in Boston.  Steve Worland, Ph.D., President and Chief Executive ... its clinical development programs, setrobuvir and ANA773. Dr. ...
... (NYSE Amex: CUR ) announced that President ... Stifel Nicolaus Annual Healthcare Conference on Wednesday, September 7 ... opportunities and advancements in neural stem cell pharmaceuticals and ... the ongoing ALS trial at Emory University. ...
Cached Biology Technology:The quantum tunneling effect leads electron transport in porphyrins 2Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 2Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 3Neuralstem President and CEO to Present at the 2011 Stifel Nicolaus Annual Healthcare Conference 2Neuralstem President and CEO to Present at the 2011 Stifel Nicolaus Annual Healthcare Conference 3
The LAS-3000 imaging system combines new CCD camera technology with a simplified user interface to provide significantly improved system sensitivity with a wide range of modularities. This system is...
This kit is designed to select cells labeled with biotinylated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
This pump accomodates StemSep ; pump feed columns of the following sizes : 0.3in., 0.5in., 0.6in., and 1.0in.....
... assays. The TUNEL-based assay kit provides complete ... for convenient detection of DNA fragmentation in ... offers an one-step labeling of apoptotic cells. ... hallmark of apoptosis in mammalian cells. MBLs ...
Biology Products: