Navigation Links
Novel regulatory mechanism identified for key tumor suppressor p53

the availability of a repressive mechanism such as the one outlined in the new study might be crucial for cellular survival.

"You can imagine that if the p53 protein were present at all times and able to bind to DNA, cells would be in big trouble," Berger explains. "They wouldn't be able to divide, and they'd die. We think this new mechanism may be a way for the cell to keep p53 turned off but present, ready to be activated if the DNA should be damaged."

In their study, the scientists identified an enzyme called Smyd2 that adds a methyl group to the p53 protein at a specific site, with the result being that p53 cannot bind to DNA and, therefore, cannot act.

"The ability to bind to DNA is critical for p53's function," says Jing Huang, Ph.D., one of the study's two lead authors. "What we found was that methylation at the site we identified prevents p53 from binding to DNA, which also explains why it's a repressive modification."

Berger and Huang note that this is one of only a small number of studies to identify methylation as playing a role in regulating the activity of proteins that are not histones. Histones are relatively small proteins around which DNA is coiled to create structures called nucleosomes. Compact strings of nucleosomes, then, form into chromatin, the substructure of chromosomes.

With histones, methylation is well recognized as a regulatory mechanism, but the fact that other proteins are also be modified in the same way is a relatively new observation. Berger believes that scientists will likely find this type of regulatory mechanism at work in many other protein systems over the next few years.

Interestingly, only one other study has shown a role for methylation in regulating p53. In that study, a methyl group added to a specific site on p53 called K372 was shown to activate the tumor-suppressor molecule rather than repress it.

The site identified in the current study, dubbed K370, is ad
'"/>

Source:The Wistar Institute


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel antiviral technology inhibits RSV infection in mice
4. Novel Enzyme Shows Potential As An Anti-HIV Target
5. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
6. Discovery Could Lead To Novel Approaches In HIV Treatment
7. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
8. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
9. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
10. Novel live reporting system to track cells
11. Field of beams - Novel system uses polarized light pulses to reveal crop health
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel regulatory mechanism identified for key tumor suppressor

(Date:3/24/2015)... 2015   NexID Biometrics LLC, whose spoof-mitigation ... today announced the beginning of shipments of version 2.0 ... The company, based in Potsdam, N.Y. ... Expo, which began here today at the Walter E. ... of its SDK boosts the accuracy rate range to ...
(Date:3/23/2015)... March 23, 2015   HOYOS Labs , a ... today announced that the Company will demonstrate multiple biometrics-based ... and consumers at Connect:ID on March 23 through 25, ... Labs will highlight the IEEE Biometric Open Protocol Standard; ... and enterprise access control system. BOPS was invented by ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ) ... Sensors Market Forecast and Opportunities 2020" report ... is projected to grow at a CAGR over ... industrial and healthcare sectors are the key application ... adoption of MEMS technology in sensors is growing ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... live outdoors in the city do their darnedest to steer ... cats cause less damage to wildlife in urban green spaces, ... dodging, the study suggests. And they live longer and are ... their use of the urban landscape. They,re not using the ...
... Biology Kim Lewis promises to overcome one of the ... groundbreaking study published Wednesday in the journal Nature ... and eliminate methicillin resistant staphylococcus aureus , or ... kept it one step ahead of researchers. That is, ...
... uncovered an underutilized berry that could be the new super ... Journal of Food Science , published by the Institute of ... lycopene and a related acidic compound, methyl-lycopenoate, which are important ... red fruit has a tart flavor, and has historically been ...
Cached Biology News:Feral cats avoid urban coyotes, are surprisingly healthy 2Feral cats avoid urban coyotes, are surprisingly healthy 3Feral cats avoid urban coyotes, are surprisingly healthy 4Northeastern researchers have discovered a new treatment to cure MRSA infection 2Northeastern researchers have discovered a new treatment to cure MRSA infection 3
(Date:4/21/2015)... Apr. 21, 2015 Research and Markets ... of the "Complete 2015-16 Induced Pluripotent Stem ... offering. Stem cell research and experimentation ... decades, as stem cells have the unique ability ... unspecialized nature allows them to differentiate into a ...
(Date:4/21/2015)... 2015 Contract Research Organization XenoTech, LLC ... into a new 41,500 ft2 facility. The planned move ... at 16825 W. 116th St. in Lenexa, KS. The ... customized laboratory space, will remain in the Kansas City metro ... more than twenty years ago. Remaining in the Kansas ...
(Date:4/21/2015)... Calif. , April 21, 2015  Scientists ... not-for-profit genomic research organization, published a paper today ... type of microalgae called diatoms. The researchers, led ... and senior author Philip Weyman , Ph.D., ... enable better understanding of diatom genetics and thus ...
(Date:4/21/2015)... -- Merrimack Pharmaceuticals, Inc. (Nasdaq: MACK ) today announced ... of MM-141, a bispecific antibody targeting IGF-1R and ErbB3.  ... Dr. Mansoor Saleh , MD at the 2015 ... Philadelphia, PA.  The trial evaluated the ... in combination with everolimus or with nab-paclitaxel and gemcitabine ...
Breaking Biology Technology:Global Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report 2XenoTech Plans Expansion to New Global Headquarters after Impressive Revenue Growth in 2014 2XenoTech Plans Expansion to New Global Headquarters after Impressive Revenue Growth in 2014 3Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 2Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 3First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 2First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 3First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 4First-in-Human Phase 1 Trial of MM-141 Demonstrates Activity in Biomarker Positive Patients 5
... Inc. (Amex: ADL ), today announced the promotion ... (COO) and CFO. The Company is also,expanding its management ... of International Marketing and Sales and Mr. Raymond Gatchalian ... and CFO, Mr. Ariura will lead the day-to-day operations ...
... SNDY) is pleased to announce that the Company has ... St. Mary,s,Hospital in Waterbury, CT. St. Mary,s has been ... it has chosen to continue using the,Company,s surgical products., ... in the history of Greater,Waterbury, providing nearly a century ...
... CHICAGO, Nov. 6 Advanced Life Sciences,Holdings, Inc. ... in the,discovery, development and commercialization of novel drugs ... diseases, today,announced its financial results for the third ... ), The net loss available to common ...
Cached Biology Technology:AMDL, Inc. Promotes CFO Akio Ariura to Chief Operating Officer and Expands Management Team 2AMDL, Inc. Promotes CFO Akio Ariura to Chief Operating Officer and Expands Management Team 3AMDL, Inc. Promotes CFO Akio Ariura to Chief Operating Officer and Expands Management Team 4Solos Endoscopy, Inc. Receives Purchase Order from Connecticut Hospital 2Advanced Life Sciences Announces Third Quarter 2008 Financial Results 2Advanced Life Sciences Announces Third Quarter 2008 Financial Results 3Advanced Life Sciences Announces Third Quarter 2008 Financial Results 4Advanced Life Sciences Announces Third Quarter 2008 Financial Results 5Advanced Life Sciences Announces Third Quarter 2008 Financial Results 6Advanced Life Sciences Announces Third Quarter 2008 Financial Results 7Advanced Life Sciences Announces Third Quarter 2008 Financial Results 8Advanced Life Sciences Announces Third Quarter 2008 Financial Results 9Advanced Life Sciences Announces Third Quarter 2008 Financial Results 10Advanced Life Sciences Announces Third Quarter 2008 Financial Results 11
ANTI PIG LDH H4...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
... use in refrigerators, freezers, or liquid nitrogen. Conveniently sized ... for color coding to project, user, lab, etc. Holes ... cool air circulation. Supplied with 10 x 10 (11.6 ... Box dimensions: 13 x 13 x 5.1 cm H ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Biology Products: