Navigation Links
Novel protein complex enables survival in hostile environment

lfite. "Early earth had a lot of sulfide but no oxygen until about 2.7 billion years ago. Then, the reaction of the small amounts of oxygen with sulfide would have produced an incomplete oxidation product ?sulfite," he said. "Methanogens present during the oxygenation of earth had to face this sulfite."

But Johnson and Mukhopadhyay could not find any sign of such ability in the DNA sequence data for methanogens. "It was clear that either the ancient sulfite detoxification has been lost or it is not recognizable because it is unlike any known system," Mukhopadhyay said.

The challenge of the latter possibility attracted the group to the topic. They decided to see if methanogens that live in an environment where the early earth conditions are preserved ?deep-sea hydrothermal vents ?still have the ancient detoxification system.

Inside a hydrothermal vent, sulfide-containing superheated water at 350 C (662 F) mixes with cold oxygen-containing water, creating cooler environments -- 48 to 94 C (118 to 200 F) -- where M. jannaschii can thrive. "This sulfide-oxygen mixture can also generate sulfite. Therefore, M. jannaschii experiences conditions that existed on early earth," Mukhopadhyay said.

He knew that Lacy Daniels, his mentor at the University of Iowa, and Negash Belay, a colleague during his graduate studies, had found sulfite assimilation ability in an organism closely related to M. jannaschii, but had not investigated how that organism handled the sulfite toxicity. Putting all these pieces of information together, Johnson and Mukhopadhyay hypothesized that M. jannaschii has a sulfite-reducing enzyme and began to search for this system.

Protein analysis of M. jannaschii from sulfite-free and sulfite-enhanced environments revealed that M. jannaschii tolerates sulfite and even uses it as a sulfur source by expressing an enzyme not seen previously. The enzyme, which is located on the cell membrane, converts toxic sulfite into
'"/>

Source:Virginia Tech


Page: 1 2 3 4 5

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel antiviral technology inhibits RSV infection in mice
4. Novel Enzyme Shows Potential As An Anti-HIV Target
5. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
6. Discovery Could Lead To Novel Approaches In HIV Treatment
7. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
8. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
9. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
10. Novel live reporting system to track cells
11. Field of beams - Novel system uses polarized light pulses to reveal crop health
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel protein complex enables survival hostile environment

(Date:12/17/2014)... The Defense Logistics Agency is insourcing its efforts ... microcircuits from entering into its supply chain. ... initiative dubbed DNA marking. The capability will validate the ... the supply chain. The new quality control measures will ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader in ... biometric technology to industry leaders such as Intel, Jabra, ... validated, biometric wearable products. These products will be showcased ... Las Vegas . "Our ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming the travel ... international borders. Over the past decade, ePassports, biometric readers, ... self process through border control via eGates and Automated ... airports, seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... N.J. and JAMAICA PLAIN, Mass., April 21, 2009 ... Medarex, Inc. (NASDAQ: MEDX) and Massachusetts Biologic Laboratories ... (UMMS) today announced that they have signed an ... (also known as MDX-066/MDX-1388 and MBL-CDA1/MBL-CDB1), an investigational ...
... in the cell and do all sorts of work, but ... know where to go? "There,s no little man sitting ... Arnold, molecular and computational biologist at the USC College of ... them encoded information that tells them where to go in ...
... Colorado and TUSTIN, Calif., April 21, 2009--Peregrine ... biopharmaceutical company developing monoclonal antibodies for the ... today reported that two preclinical studies presented ... provided further confirmation of the immunomodulatory mechanisms ...
Cached Biology News:Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck 2Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck 3Autopilot guides proteins in brain 2Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies 2Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies 3Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies 4
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to the ... consultants, Protocol Networks has recently announced its expansion into ... his company has attracted several clients in The Constitution ... as others. With the success of these engagements, Rogers ...
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... January 22, 2015 Dr. Greg Leyer of ... annual Scripps Natural Supplements Pre-Conference seminar on probiotics in San ... an annual continuing education conference for health care professionals. This ... the topic of probiotics in health. Dr. Leyer spoke about ...
(Date:1/22/2015)... 2015 Selexis SA, a serial innovation ... Banks (RCBs) used for drug discovery to commercial manufacturing, ... include Next-Generation Sequencing (NGS) data packages. The ... manufacturing by ensuring the integrity of the gene, validation ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2
... added four, six and eight port right-angle BNC connectors to its ... savings as a replacement for applications where a number of single ... ... Sunnyvale, CA (PRWEB) April 29, 2009 -- Regal Electronics ...
... - 4TB4Free , ... Austin, Texas (PRWEB) April 29, ... for accessing, storing and distributing content, today announced the release of ... can run virtual CAStor nodes in a single, physical server chassis. ...
... MEDX ) is scheduled to host a ... Time on Thursday, April 30, 2009 to review Medarex,s ... of 2009.To access the call live, please dial 1-877-397-0272 ... through the Investor Relations section of Medarex,s website at ...
Cached Biology Technology:Regal Introduces Four, Six and Eight Port Filtered and Un-Filtered Right Angle BNC Connectors 2Caringo Delivers Storage Cluster in a Box with CAStor 3.0 2Medarex to Host Business and Financial Update Conference Call on Thursday, April 30, 2009 2
Makes gels easy to load and track during electrophoresis. 10X concentrate of Bromophenol Blue, glycerol solution....
"BioTracker 6X Bromophenol Blue Tracking Dye is composed of 60% St DI H2O, 30% Glycerol, 10% 10XTE, 0.25% BPB Dye and 0.85% SDS....
Request Info...
Agarose, low melting/gelling temperature, high MW separation (>1000 bp), 25 g. Suitable for enzymatic modifications. Nuclease-free.Gel point: 24-30 C, EEO (-mr): 300 gm/cm2. Category: Nucleotides &...
Biology Products: