Navigation Links
Novel live reporting system to track cells

New findings show an iron storage molecule in the cell can serve as an advanced tool for mapping gene expression. Future gene therapy may use a technique in which non-invasive magnetic resonance imaging (MRI) is used to track this molecule. The results of this research, conducted by Prof. Michal Neeman of the Weizmann Institute's Biological Regulation Department, were published in the research journal Neoplasia.

Neeman, together with Dr. Batya Cohen of the Institute's Molecular Genetics Department, developed the capacity of the iron-bearing ferritin molecule to serve as a sort of gene "spy" by making genetic modifications to cells. This approach rendered ferritin sensitive to tetracycline (TET), a common antibiotic, so that when TET is present, the ferritin is "off" and when TET is absent, ferritin is "on." Tumor cells with modified ferritin were inserted into living mice and then tracked with MRI. The researchers hampered the expression of ferritin in the inserted cells through the administration of TET. When they stopped the TET, the "switch" turned on, triggering ferritin molecules to increase their numbers, thereby causing an increase in iron uptake within the tumor cells. The contrast between the iron content in these and in the normal surrounding cells showed up in the MRI (which is sensitive to magnetic particles such as iron), effectively identifying the genetically modified cells.

This method grew out of a joint vision that originated 10 years ago in collaboration with the late Dr. Yoav Citri. Ferritin's advantage is that it is visible in MRI without the need for an additional contrast material. This technique has far-reaching implications for monitoring the progress of gene therapy, such as that used to reactivate the body's production of insulin in the treatment of diabetes, because the genes can be "tagged" prior to injection. Therapeutic genes can then be tracked by MRI to ensure the target is reached and the desired activations occur. Pr of. Neeman: "The use of ferritin as a reporter gene would be particularly beneficial in those cases where administration of contrast material is compromised by barriers, including embryonic development and the central nervous system."


'"/>

Source:American Committee for the Weizmann Institute of Science


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel antiviral technology inhibits RSV infection in mice
4. Novel Enzyme Shows Potential As An Anti-HIV Target
5. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
6. Discovery Could Lead To Novel Approaches In HIV Treatment
7. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
8. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
9. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
10. Field of beams - Novel system uses polarized light pulses to reveal crop health
11. Novel compounds show promise as safer, more potent insecticides
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... (PRWEB) , ... October 09, ... ... organization that identifies, counsels, and supports high-growth, high-impact life science and biotechnology ... representing 8 national nonprofit disease foundations to discuss their investment philosophies, explain ...
(Date:10/11/2018)... ... October 11, 2018 , ... Better lives ... National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL). The Institute, a public-private partnership ... biopharmaceutical manufacturing and workforce development in the United States. Biopharmaceuticals are important because ...
(Date:10/5/2018)... ... 04, 2018 , ... High dose of biotin may cause interference with many ... troponin has serious clinical complications. There is an increasing trend of high dose biotin ... , High dose of biotin supplement use may continue to increase due to its ...
Breaking Biology News(10 mins):
(Date:10/11/2018)... ... October 11, 2018 , ... Avery Products Corp., the world’s ... with HP, the global leader in printing, has obtained the British Standard 5609 ... HP PageWide Printers. , The award-winning Avery UltraDuty GHS Chemical Labels, combined with ...
(Date:10/3/2018)... ... October 03, 2018 , ... Milwaukee Area Technical College (MATC), a public, two-year ... 3-7 p.m. in Room T129 in the T Building, 101 N. 6th St., to ... A ribbon cutting and formal program will be held at 4 p.m. , MATC ...
(Date:9/29/2018)... GARDEN GROVE, Calif. (PRWEB) , ... September 29, ... ... Voxx.Gateway, an analytics product enabling mid-level and early-stage companies to access the power ... working to make our solutions available to a broader market that didn’t necessarily ...
(Date:9/27/2018)... , ... September 26, 2018 , ... ... is a platform that aims to build the first human digitome, a digital ... and real-world data through a seamless integration of all data sources. Dr. Michelle ...
Breaking Biology Technology: