ISAM effectively extends the region of the image that is in focus, using information that was discarded in the past.
"We have demonstrated that the discarded information can be computationally reconstructed to quickly create the desired image," Marks said. "We are now applying the technique to various microscopy methods used in biological imaging."
In their paper, the researchers demonstrate the usefulness of computed image reconstruction on both phantom tissue and on excised human breast-tumor tissue.
"ISAM can assist doctors by providing faster diagnostic information, and by facilitating the further development of image-guided surgery," Boppart said. "Using ISAM, it may be possible to perform micron-scale imaging over large volumes of tissue rather than resecting large volumes of tissue."
The versatile imaging technique can be applied to existing hardware with only minor modifications.
Source:University of Illinois at Urbana-Champaign