Navigation Links
Novel antiviral technology inhibits RSV infection in mice

A novel antiviral treatment combining nanoparticle and gene silencing technologies thwarts attacks of respiratory syncytial virus (RSV) -- a virus associated with severe bronchitis and asthma, an animal study by University of South Florida researchers found. The study was reported in the January 2005 issue of the journal Nature Medicine. RSV infects lung cells and can be life-threatening in very young children, the elderly and those with compromised immune systems. No vaccine or widespread antiviral treatment is available for the infection.

Researchers at USF's Joy McCann Culverhouse Airway Disease Research Center, working with scientists from the Moffitt Cancer Center and TransGenex Nanobiotech Inc., used a revolutionary new technology known as RNA interference, or gene silencing, to knock out one of the key proteins needed for RSV to multiply in the lungs. The virus harnesses this protein, known as NS1, to block the body's own antiviral response, which would normally kill RSV before it could gain a foothold. "This is an exciting advance in the fight against respiratory syncytial virus infection," said Shyam S. Mohapatra, PhD, principal investigator of the study and director of basic research at the USF Division of Allergy and Immunology. "We found that RNA interference targeting a virus's NS1 gene can be administered in the form of a nasal drop or spray. The treatment keeps the host's natural antiviral shield intact and attenuates virus reproduction, providing substantial protection from severe infections over days to weeks." Dr. Mohapatra and his team developed nose drops containing vectors capable of producing small fragments of RNA (siRNA). These fragments were encapsulated within chitosan nanoparticles -- miniscule naturally-occurring, biodegradable particles that stick to mucous-producing cells lining the lungs. The RNA produced is specifically designed to suppress the protein NS1. Without NS1, the host antiviral defense remains intact and the virus ca
'"/>

Source:Eurekalert


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel Enzyme Shows Potential As An Anti-HIV Target
4. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
5. Discovery Could Lead To Novel Approaches In HIV Treatment
6. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
7. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
8. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
9. Novel live reporting system to track cells
10. Field of beams - Novel system uses polarized light pulses to reveal crop health
11. Novel compounds show promise as safer, more potent insecticides
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel antiviral technology inhibits RSV infection mice

(Date:5/16/2013)... shown a gene involved in neurodegenerative disease also plays ... circadian clock. , In a study of the ... Ataxin-2, keeps the clock responsible for sleeping and waking ... of the fruit fly,s sleep-wake cycle is disturbed, making ... fly. , The discovery is particularly interesting because ...
(Date:5/16/2013)... Integrated Biometrics patented LES (Light Emitting ... film transistor camera introduces Sherlock, a fingerprint scanner ... the smallest and lightest form factor available on ... ID FAP 45, Certified scanner is highly efficient ... weight when compared to optical scanners. ...
(Date:5/16/2013)... Top neuroscientists from Canada and around the world ... Annual Canadian Neuroscience Meeting will showcase the latest ... system and reveal clues to understanding the disorders ... neuroscience research, and this meeting will showcase the ... the world," says Sam David, President of the ...
Breaking Biology News(10 mins):Gene involved in neurodegeneration keeps clock running 27th Annual Canadian Neuroscience Meeting, Toronto, May 20-24, 2013 2
... cancer cells lack a certain protein, it could be ... the first step towards forming metastases. Scientists at the ... the previously unknown cell signal factor SCAI (suppressor of ... of tumor cells in laboratory tests. When the factor,s ...
... April 8, 2009 Extreme temperatures and limited water ... losses to agriculture around the world. Ben-Gurion University ... research collaboration with Bayer BioScience N.V., a subsidiary of ... to these challenges. The agreement builds upon the ...
... study conducted in the Midwestern United States examined the ... uncultivated soils, vastly advancing the knowledge of water,s effects ... that is related to the physical-chemical state of the ... determine soil quality. During the wet season in the ...
Cached Biology News:How tumor cells move 2Ben-Gurion University of the Negev signs collaborative contract with Bayer CropScience 2Impact of floods on soils 2
(Date:5/16/2013)... May 16, 2013 ISPE ... A. Myers, CAE, to the newly created position ... new role, Myers will be responsible for stimulating ... production strategies, advancing the Society’s Member-led and staff-driven ... continuing to refine organizational, membership and product marketing. ...
(Date:5/16/2013)... A new selection of laboratory ... is designed to meet the dynamic needs of ... new Cole-Parmer® MS-3400 Centrifuges are clinical ... They ensure a powerful and complete separation of ... standard four-place swinging buckets hold 50-mL tubes. With ...
(Date:5/16/2013)... , May 16, 2013  HealthSparq, a ... of the nation,s largest regional health plans, will ... Health Insurance Plans (AHIP) Institute 2013 conference on ... survey results showing how health insurance companies across ... the consumer and marketplace demands for increased healthcare ...
(Date:5/16/2013)... 2013 As the weather warms, women everywhere ... Spring looks. While most make a statement with fashion, many ... find the warmer weather mixes makeup and sweat to produce, ... onset of acne during warmer months, Adult Acne treatment ... users the best ways to deter breakouts. , Recently, ...
Breaking Biology Technology:ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2Cole-Parmer Offers Enhanced Selection of Centrifuges 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 2HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013 3Adult Acne Treatment, Probiotic Action Shares New Tips for Women on How to Fight Acne While Wearing Makeup 2
... , Three-of-Four Patients Surveyed Experience Daily Pain From ... the European League Against Rheumatism Annual Congress of ... Results from the Rheumatoid Arthritis: Insights, Strategies ... rheumatoid arthritis (RA) patients throughout Europe and Canada ...
... SPRINGFIELD, Va., June 9 Methuselah Foundation has identified ... of bio-printing. The US Department of Health and ... be the standard of care for replacing all tissue/organ ... Methuselah Foundation, is applying its breakthrough organ printing technologies ...
... and Patient Reported Outcome Strategies , , PITTSBURGH, ... leader in electronic patient reported outcomes (ePRO) solutions and ... ePROficiency(TM) Web seminar series on Patient Reported Outcomes (PRO). ... a continuation of invivodata,s educational initiative which focuses on ...
Cached Biology Technology:New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 2New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 3New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 4New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 5New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 6Printing New Organs: Foundation Funds Medical Technology That Replicates Human Tissue 2invivodata Announces ePROficiency 2009 Web Seminar Series 2
... stability and convenience from the former kit #17295. ... this problem but also produced some advantages as ... of HRP conjugated antibody from lyophilized product to ... stability of the conjugate has improved so that ...
... multi-purpose, high gel-strength agarose suitable for a ... conventional constant field to Pulsed Field Gel ... strength and exclusion limits, Multi ABgarose can ... running times. This in turn means reduced ...
... The IDS EIA kit is a complete ... Vitamin D (1,25D) in human serum or ... immunoextraction system found in the IDS 1,25D ... The assay comes with ready to use ...
... is a molecular screening, low melting point ... sieving. It is recommended for separation of ... such as PCR products. Micro ABgarose is ... not recommended for blotting techniques. At a ...
Biology Products: