Navigation Links
Novel antiviral technology inhibits RSV infection in mice

A novel antiviral treatment combining nanoparticle and gene silencing technologies thwarts attacks of respiratory syncytial virus (RSV) -- a virus associated with severe bronchitis and asthma, an animal study by University of South Florida researchers found. The study was reported in the January 2005 issue of the journal Nature Medicine. RSV infects lung cells and can be life-threatening in very young children, the elderly and those with compromised immune systems. No vaccine or widespread antiviral treatment is available for the infection.

Researchers at USF's Joy McCann Culverhouse Airway Disease Research Center, working with scientists from the Moffitt Cancer Center and TransGenex Nanobiotech Inc., used a revolutionary new technology known as RNA interference, or gene silencing, to knock out one of the key proteins needed for RSV to multiply in the lungs. The virus harnesses this protein, known as NS1, to block the body's own antiviral response, which would normally kill RSV before it could gain a foothold. "This is an exciting advance in the fight against respiratory syncytial virus infection," said Shyam S. Mohapatra, PhD, principal investigator of the study and director of basic research at the USF Division of Allergy and Immunology. "We found that RNA interference targeting a virus's NS1 gene can be administered in the form of a nasal drop or spray. The treatment keeps the host's natural antiviral shield intact and attenuates virus reproduction, providing substantial protection from severe infections over days to weeks." Dr. Mohapatra and his team developed nose drops containing vectors capable of producing small fragments of RNA (siRNA). These fragments were encapsulated within chitosan nanoparticles -- miniscule naturally-occurring, biodegradable particles that stick to mucous-producing cells lining the lungs. The RNA produced is specifically designed to suppress the protein NS1. Without NS1, the host antiviral defense remains intact and the virus ca nnot reproduce. Mice treated intranasally with the gene-silencing nanoparticles, before and after infection with RSV, showed significantly lower levels of virus in the lung and less airway inflammation and hyper-reactivity than untreated mice.
'"/>

Source:Eurekalert


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Novel technology detects human DNA mutations
3. Novel Enzyme Shows Potential As An Anti-HIV Target
4. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
5. Discovery Could Lead To Novel Approaches In HIV Treatment
6. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
7. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
8. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
9. Novel live reporting system to track cells
10. Field of beams - Novel system uses polarized light pulses to reveal crop health
11. Novel compounds show promise as safer, more potent insecticides

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/19/2016)... TORONTO , 19 de diciembre de 2016  Mosaic Biomedicals ... el desarrollo acelerado de MSC-1, un anticuerpo humanizado que se espera ... en 2017, con múltiples sitios previstos a lo largo de Europa ... MSC-1 ... factor inhibidor de leucemia (LIF), una citoquina pleiotrópica que se sobreexpresa ...
(Date:12/15/2016)... and BADEN-BADEN, Germany , December ... leading global financial services provider, today announced an agreement with ... behavioural biometrics, to join forces. The partnership will enable clients ... strategies in compliance with local data protection regulation. ... In order to ...
(Date:12/15/2016)... Mich. , Dec. 15, 2016  There is ... car doors or starting the engine. Continental will demonstrate ... Las Vegas . Through the combination ... Start and Entry) and biometric elements, the international technology ... of vehicle personalization and authentication. "The integration ...
Breaking Biology News(10 mins):
(Date:1/18/2017)...  Caris Life Sciences, a leading innovator in ... private funder of pancreatic cancer research, are collaborating ... of immunotherapy in the treatment of pancreatic cancer. ... identify potential trial candidates based on biomarker expression ... study investigators. The Lustgarten Foundation is a sponsor ...
(Date:1/17/2017)... Foreside, Maine (PRWEB) , ... January 17, 2017 ... ... announce the addition of Rheumatoid Factor (RF) to its VALIDATE® SP2 calibration verification ... Rheumatoid Factor in a human serum base. Each VALIDATE® SP2 kit is prepared ...
(Date:1/17/2017)... Jan. 17, 2017  An international team of ... and St. Boniface Hospital Albrechtsen Research Centre/University of ... an unmet health need affecting nearly one in ... Clinical Investigation, their results identify small molecule drugs ... reverse neuronal injury in animal models of metabolic, ...
(Date:1/17/2017)... , Jan. 17, 2017   Pulmatrix, Inc . ... company developing innovative inhaled therapies to address serious pulmonary ... fungal infections in the lungs of CF patients, PUR1900, ... (QIDP) by the U.S. Food & Drug Administration. ... designed to speed the development of novel drugs against ...
Breaking Biology Technology: