Navigation Links
North & South American researchers find architectural abnormalities in T. cruzi ribosome

ith its small subunit. In the new study, the most peculiar feature showed up on the small subunit of the parasite's ribosome.

The researchers found a gigantic addition tacked onto one side of the small subunit, resembling a turret topped by a spire. "It's larger than anything we've seen anywhere, as far as peripheral additions in ribosomes are concerned," Frank said. "It's almost freestanding."

The exact purpose of the turret and its spire is unknown, but the researchers suspect the function will be as unique as its architecture. They speculate that it may have something to do with the 39-nucleotide leader of the mRNA that the parasite's ribosomes must process. The spot where the ribosome binds to the mRNA, for example, is roughly as far away from the turret and spire as the length of the 39-nucleotide leader sequence.

"It could provide a unique scanning mechanism different from other eukaryotes," Frank said. "For instance, the splice leader of the mRNA might attach at the turret, which may swivel out and drag the mRNA across the binding site on the ribosome to initiate protein translation."

The findings may also advance studies of parasitic relatives Trypanosoma brucei, which causes sleeping sickness in Africa, and Leishmania, a parasite spread by sand flies. Higher resolution models of the ribosome structure will be needed to design targeted drugs, Frank said.


'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
2. No relief for Pacific Northwest drought
3. Survey finds silver contamination in North Pacific waters
4. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
5. Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska
6. Red delicious, Northern Spy apples have most antioxidants, chemists find
7. FSU scientist warns North Atlantic right whale facing extinction
8. Proposal would allow wild animals to roam North America
9. Drug resistant avian influenza viruses more common in Southeast Asia than North America
10. Skin disease common among Hispanic farmworkers in North Carolina, research shows
11. First wolverine radio-collared in Pacific Northwest
Post Your Comments:
(Date:2/24/2015)... YORK , Feb. 24, 2015 This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for the ... provided for these markets. Market data and analytics are derived ...
(Date:2/24/2015)... , Feb. 24, 2015 Research and ... the addition of the "Global 2D Gesture ... The analysts forecast the Global ... CAGR of 32.12% over the period 2014-2019 ... in non-traditional sectors is one of the major ...
(Date:2/19/2015)... , Feb .19, 2015 Research and ... the addition of the "Military Electro-Optical / ... Sensor Technology, by Platform - Forecast to 2020" ... The military electro-optical/infrared systems market is expected to ... CAGR of 7.71%. This report segments ...
Breaking Biology News(10 mins):World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11Global 2D Gesture Recognition Market 2015-2019 with Cognitec Systems, CogniVue, eyeSight Mobile Technologies & PointGrab Dominating 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3
... study calling for levels of obesity among South Asians to ... of Leicester. A team from the University,s Departments ... for the point at which South Asians should be classed ... published in PLoS One , a journal of the ...
... Management Institute ( http://cmi.vt.edu/ ), a research center ... Environment, has provided technical expertise for the world,s ... Forest Degradation (REDD) project to receive certification under ... ( http://www.v-c-s.org/ ). The UN-REDD Programme ( http://www.un-redd.org/ ...
... to scientists, carbon monoxide (CO), a tasteless, colorless and odorless ... also highly toxic to human beings. Found in the exhaust ... killer" because excessive inhalation is lethal, poisoning the nervous system ... Itzhak Schnell of Tel Aviv University,s Department of Geography and ...
Cached Biology News:New research calls for lower limit to be set for South Asian obesity level 2First UN carbon offset project certified 2Carbon monoxide -- the silent calmer? 2
(Date:2/27/2015)... 2015 A paper published today, " ... " in Science Translational Medicine, demonstrates ... reduce the risk associated with investing in the ... levels of funding for developing so-called "orphan" drugs. ... collaboration between scientists at the National Center for ...
(Date:2/27/2015)... 2015 Bionomics Limited (ASX:BNO, ADR:BMICY) is to ... BNC105 in patients with metastatic renal cancer at the ... . The data will be presented by Dr. ... Comprehensive Cancer Center in California ... data identifies Ferritin and IL-8 as two baseline biomarkers ...
(Date:2/27/2015)... , Feb. 27, 2015  Steep Hill, the industry ... and internationally, intends to open a full service medical ... Mexico , bringing advanced scientific tools and methodology ... Steep Hill is currently the only laboratory licensed ... potency and contaminant testing in order to meet the ...
(Date:2/26/2015)... , Feb. 26, 2015  23andMe, the leading personal ... Black as Privacy Officer and Corporate Counsel. Black ... privacy laws as well as health care regulations. As ... will be responsible for reviewing, updating and enhancing the ... U.S. and abroad. She joined the company January 5, ...
Breaking Biology Technology:New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 223andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2
... equipment manufacturer Gehl Co. has developed a new ... functions using a compact, wireless remote control pendant from outside ... hand-held pendant can be used to raise, lower, extend and ... , ,"Our goal was to add a new dimension of ...
... years of living on government pay, I'm finally banking a few bucks. ... few others, and getting paid by a law firm and an accounting ... to speak, which might surprise those folks who poked fun at "the ... I didn't admit it: I miss the flags, fanfare and fun of ...
... The Medical College of Wisconsin has been awarded ... Medical Countermeasures against Radiation, an effort to take the college's ... radiation. , ,The institute is one of seven centers being ... Diseases (NIAID) to establish a plan for identifying and ...
Cached Biology Technology:Reading Tommy Thompson's diary: Imagining unspoken thoughts about 2008 2Reading Tommy Thompson's diary: Imagining unspoken thoughts about 2008 3Medical College getting $18.1 million to study radiation damage treatments 2
... Sophions newly introduced QPatch HT is taking automated ... powerful level. With its ability to generate thousands ... is enabling new screening paradigms in ion channel ... with the same high quality afforded by conventional ...
... mouse embryonic stem cells to dopaminergic neurons. ... where they are mainly located in the ... the retrorubral field. These dopaminergic (DA) neurons ... ( e.g.projections to the caudate nucleus, putamen ...
... Microarrays designed for RNA aptamer screening and ... and powerful Paraflo microfluidic on-chip synthesis platform. ... be synthesized on-chip and LC Sciences can ... microarrays are available as part of our ...
... the C-terminal end of the mouse retinoic acid receptor beta (RAR*). ... of RAR*. The sequence of PEP-005 is (amino to carboxy terminus): ... S - S - V - E - N - S - ... L - L - Q (The N-terminal cysteine has been added ...
Biology Products: