Navigation Links
North & South American researchers find architectural abnormalities in T. cruzi ribosome

A Howard Hughes Medical Institute investigator from Albany, New York, and an HHMI international research scholar from Buenos Aires, Argentina have combined their expertise to identify two peculiar features of the protein-making machinery of the parasite that causes Chagas disease. Their findings could help scientists develop a safe and effective drug for the disease, whose cardiac complications kill up to 30 percent of those infected.

The unusual structure of the ribosome, published online the week of July 4, 2005, in the Proceedings of the National Academy of Sciences, also suggests that the parasite has a unique scanning mechanism for translating genetic information into proteins.

"This may lead the way to the discovery or development of drugs that are specific against an essential mechanism of the life of the parasite and do not affect the infected organism," said parasitologist Mariano Levin, an HHMI international research scholar at the Institute for Research on Genetic Engineering and Molecular Biology in Buenos Aires and co-author of the study.

Levin met senior author Joachim Frank at a science meeting at HHMI headquarters in Chevy Chase, Maryland. Frank is an HHMI investigator at Health Research Inc., at the Wadsworth Center in Albany, New York, who had pioneered the analysis of ribosome structures by a method he developed for three-dimensional reconstruction of large molecules using electron microscopy and image processing. Levin told him the story of Chagas and the need to know more about the structure of the parasite's ribosome.

A ribosome is basically a double ball made mostly of RNA and over 50 proteins. The balls, which are of unequal size, are called small and large subunits. After a string of messenger RNA (mRNA) copies the information encoded on a gene, it enters a sea of ribosomes, where that genetic information is translated into a protein product.

Scientists have long known there was something strange about
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
2. No relief for Pacific Northwest drought
3. Survey finds silver contamination in North Pacific waters
4. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
5. Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska
6. Red delicious, Northern Spy apples have most antioxidants, chemists find
7. FSU scientist warns North Atlantic right whale facing extinction
8. Proposal would allow wild animals to roam North America
9. Drug resistant avian influenza viruses more common in Southeast Asia than North America
10. Skin disease common among Hispanic farmworkers in North Carolina, research shows
11. First wolverine radio-collared in Pacific Northwest
Post Your Comments:
(Date:11/10/2014)... detergent pods began appearing on U.S. store shelves in ... numbers ever since. The small packets can be tossed ... out a liquid or powder. The convenience, though, has ... study from researchers at Nationwide Children,s Hospital found that ... reports of 17,230 children younger than 6 years of ...
(Date:11/7/2014)... -- In conjunction with the Glendale and ... of the Verdugos has announced the " GLENDALE ... initiative to keep the Verdugo Regional Crime Lab operational after ... of existence, the Lab has processed more than 400 DNA ... "Because our number one priority is the wellbeing ...
(Date:11/6/2014)... Fla. -- A groundbreaking paper from a team of ... understanding of how plants could adapt to and survive ... research, published in the latest issue of the journal ... chromatin (the complex of DNA and proteins) is organized ... so that some genes are turned on and others ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Maize analysis yields whole new world of genetic science 2
... Kosterhavet National Park was created to provide a ... researchers at the University of Gothenburg have analysed species ... national park to determine which marine areas require special ... meter manually in the national park. That,s why I,ve ...
... comes to apples, consumers like a crisp bite. Apple ... important "sensory attributes" in apples. Because new apple varieties ... to consumers, breeders are constantly searching for methods to ... test the "old-fashioned" wayusing panels of experts who taste-test ...
... POPLARVILLE, MSAzalea web blight, caused by a species ... each year on some containerized azalea cultivars during ... United States. Azalea shoots can harbor the pathogen, ... Research has indicated that simply submerging terminal ...
Cached Biology News:Life on Kosterhavet's seabed analyzed 2Computerized tool takes a bite out of traditional apple testing 2Thermotherapy rids azaleas of deadly fungal disease 2
(Date:11/27/2014)... 2014 The Europe Thermal Protective ... to provide crucial revenue forecasts. It estimates the ... at a CAGR of 7.5%, from 2013 to ... Europe Thermal Protective Clothing market report for a ... supported by various tables and figures. , ...
(Date:11/27/2014)... -- Calcivis, a medical devices company ... today announces that it has completed a first ... System. The Calcivis Caries Activity Imaging ... combination designed to transform the assessment and management ... unique, proprietary bioluminescence approach combined with a specialised ...
(Date:11/26/2014)... Texas (PRWEB) November 26, 2014 ... Industryā€¯ is a professional and in-depth research report ... Bifluoride information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/26/2014)... PHILADELPHIA , Nov. 26, 2014 ... environments. Human exploration of space requires astronauts to maintain ... safety and success, and prevent potential errors and accidents. ... little is known about how cognition is affected by ... affected. Now, Penn Medicine researchers are poised ...
Breaking Biology Technology:The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 2The Europe Thermal Protective Clothing market is estimated to grow up to $577.9 million by 2018 - Report by MicroMarket Monitor 3Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 2Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 3Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4
... - A Madison-based developer of predictive traffic information ... help of a $1 million line of credit from ... Financial Group of Santa Clara, Calif. , , TrafficCast ... of its cellular probe technology in Shanghai, China, and development ...
... Pfizer spent about $800 million to develop ... until people began to die in clinical trials. Hours ... called a halt to further trials, a decision that ... in jeopardy. , ,The drama surrounding Pfizer's high-stakes choice ...
... manufacturers polled in a recent survey say that ... pressures outweigh anxiety about offshore competition. , ,The ... consulting organization for small and mid-sized manufacturers, conducted ... themselves on performance and external market issues. , ...
Cached Biology Technology:Failure of heart drug offers lessons for drug industry 2Failure of heart drug offers lessons for drug industry 3
... Dish uses include large-scale colony-counting and plaque-lifting, ... Flexys TM automated colony picking and ... new product number, created to easily match ... yet, please order under the old Sigma-Aldrich ...
Mouse Anti-Human Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4 Monoclonal Antibody Family: New...
BD BioCoat Laminin 150 mm Culture Dishes...
...
Biology Products: