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Nobelist discovers antidepressant protein in mouse brain

ll surface, reduced serotonin signaling, decreased responsiveness to sweet reward, and were less mobile, behaviors which are considered depression-like. Also, the 5-HT1B receptors of p11 knockout mice were less responsive to serotonin and antidepressant drugs compared to those of control mice, which further implicates p11 in the main action of antidepressant medications.

"Manipulations that are antidepressant in their activity increased the level of the protein and those which are depressant reduce it," said Greengard. "It seems as though antidepressant medications need to increase p11 levels in order to achieve their effect." Future studies should elucidate exactly how antidepressants increase levels of this molecule, he added.

Also participating in the study: Per Svenningsson, Ilan Rachleff, Marc Flajolet, The Rockefeller University; Karima Chergui, Xiaoqun Zhang, Karolinska Institute; Malika El Yacoubi, Jean-Marie Vaugeois, Faculty of Medicine and Pharmacy, Rouen Cedex, France; George G. Nomikos, Eli Lilly and Company.


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Source:NIH/National Institute of Mental Health


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