Navigation Links
Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness

with all manner of stimuli, including circulating factors such as adrenaline, as well such diverse sensory signals as odorants and light. The activation of these receptors leads to the propagation of intracellular signals. Once activated the receptors are quickly turned-off by an enzyme called a G protein-coupled receptor kinase. This process is called desensitization and can limit the effectiveness of many drugs, such as opiates for pain and adrenaline for asthma, and is further associated with numerous diseases including those of the cardiovascular and pulmonary systems. If activated for a long period of time the receptors are carried into the cell and are "turned off."

In animal, cellular and biochemical experiments, the researchers found that a lack of nitric oxide leads to a decrease in beta adrenergic receptor number and function. Also, the researchers found that when SNO compounds were administered to mice they could prevent the receptors from being "turned off" by the drugs.

The researchers said these findings, if confirmed in humans, open up new avenues for the development of non-desensitizing drugs not only for heart failure and asthma but also for other conditions such as pain and high blood pressure.

"We demonstrated that when one of the systems goes awry, so does the other," said Stamler, whose laboratory has made many fundamental discoveries about the role of nitric oxide in human biology, including the discovery of SNOs' ubiquitous role in human health and disease. "When nitric oxide function is impaired by disease, therapeutic agents like beta-agonists in asthma and adrenergic stimulants in heart failure will work less well. The key now is to determine how best to manipulate these ubiquitous receptors, together with nitric oxide for the treatment of human diseases."

"In broad terms, the results of these experiments present a novel role for nitric oxide in regulating the activity of G-protein coupled receptors,
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. Aspirin reduces cardiovascular risks in men and women -- but differently
2. Eating less salt could prevent cardiovascular disease
3. Study: Predatory dinosaurs had bird-like pulmonary system
4. Researchers develop gene therapy to reverse pulmonary arterial hypertension
5. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
6. Automatic extraction of gene/protein biological functions from biomedical text
7. New research questions basic tenet of neuron function
8. Vascular structure and function improve with diet and exercise
9. Towards precise classification of cancers based on robust gene functional expression profiles
10. Researchers reveal secret of key protein in brain and heart function
11. By creating molecular bridge, scientists change function of a protein
Post Your Comments:
(Date:8/4/2015)... , Aug. 04, 2015 ... ) has announced the addition of the ... Software, and Service), Sub-Segment (Computer Forensics, Network ... Tool Types, Service, Vertical and Region - ... their offering. By Component (Hardware, ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julio de 2015 ... sobre Genómica (ICG-10,  www.icg-10.org ) del 22 al 25 ... . La conferencia celebra su décimo ... se ha convertido en una de las reuniones anuales ... ,ómicas, y es una de las conferencias científicas más ...
(Date:7/31/2015)... 31. Juli 2015 Die 10. internationale Konferenz zu ... veranstaltet und findet vom 22. bis 25. Oktober ... statt. Die Konferenz feiert in ... 2006 ist die ICG weltweit zu einem der ... ist eines der dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... substantial, recurring impact on the health and size of ... to ecologists. Following the restoration of gray wolves ... animals to monitor parasite-induced disease and death. They also ... survival and allow additional data-gathering. "Many invasive species ...
... have shown at an unprecedented level of detail how ... damage. The research, published in the journal ... Bristol, the Institut Jacques-Monod in France and Rockefeller University ... in order to understand how cellular repair pathways are ...
... and Boston, MA. Sunday, September 9, 2012 A new ... that people with the second most common type of lung ... transformed treatments for other lung cancer patients. Squamous ... colorectal, or prostate cancer, ranking second only to lung adenocarcinoma ...
Cached Biology News:Wolf mange part of nature's cycle 2Wolf mange part of nature's cycle 3Protecting genes, one molecule at a time 2New potential targets discovered for treating squamous cell lung cancers 2New potential targets discovered for treating squamous cell lung cancers 3
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes ... the University of Miami Miller School of Medicine, ... clinical trial to test for the first time ... successfully completed.  This FDA approved Phase I/II study ... transplantation and is an important first step toward ...
(Date:8/26/2015)... China Cord Blood Corporation (NYSE: CO ... provider of cord blood collection, laboratory testing, hematopoietic stem ... that the Company has been informed that Magnum Opus ... by Mr. Yuen Kam, chairman of the board of ... (the "Shares") of  Excellent China Healthcare Investment Limited ("KKR ...
(Date:8/26/2015)... ... August 26, 2015 , ... The 2015 Epigenomics & Metabolomics ... technology start-up company Asymmetrex to share the first report on progress with ... biomarker for counting adult tissue stem cells. , With a name like “H2A.Z asymmetry,” ...
(Date:8/25/2015)... Human Longevity, Inc. (HLI), the genomics-based, technology-driven company, announced today ... as Chief Operating Officer. Winham, who brings more than 25 ... report directly to HLI,s CEO, J. Craig Venter , ... Winham will be responsible for managing all HLI sequencing, laboratory ... HLI currently has three locations in San Diego ...
Breaking Biology Technology:Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4Human Longevity, Inc. Hires Life Sciences Leader, Mark Winham, as Chief Operating Officer 2
... do Xers care about? , ,Gen Xers will vote because ... are the average ages of newly married young men and ... and concerns. When a young person gets married and starts ... little longer to get there. , ,Gen Xers will vote ...
... Wis. Wisconsin took a step toward its new ... announcement that the state favors the bid of an alliance ... alliance proposes to build and manage the network dubbed ... the existing BadgerNet. The network would be available to municipalities ...
... Esser. Appleton, Wis. The head of ... to encourage angels to band together. , ,On October 19th, ... gave a lecture at the Radisson Hotel in Appleton, ... invested $18.3 billion in companies of various sizes, but only ...
Cached Biology Technology:Presidential politics and the next generation 2Wisconsin chooses likely vendors for BadgerNet 2 2Wisconsin chooses likely vendors for BadgerNet 2 3Susan Preston, entrepreneur, on how to set up angel networks 2Susan Preston, entrepreneur, on how to set up angel networks 3Susan Preston, entrepreneur, on how to set up angel networks 4Susan Preston, entrepreneur, on how to set up angel networks 5
Gastric Carcinoma Marker [BY-1 (3H11)]...
Human Dectin-1/CLEC7A Biotinylated Affinity Purified PAb...
Recognizes Kir4.1. The epitope does not share homology with any other known proteins.,SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Oth...
Profilin-1/2 (FL-140)...
Biology Products: