Navigation Links
Nicotine rush hinges on sugar in neurons

When nicotine binds to a neuron, how does the cell know to send the signal that announces a smoker’s high"

As with other questions involving good sensations, the answer appears to be sugar.

A University of Southern California study appearing with a commentary in Nature Neuroscience online proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings news of nicotine’s arrival.

Structural biologist Raymond Stevens of The Scripps Research Institute, who was not involved in the study, called it “a landmark accomplishment for the fields of structural biology and neuronal cell signaling.”

Besides substance addiction, Stevens pointed to epilepsy, schizophrenia and depression as targets for improved drugs that could result from the study’s findings.

The study provides the first detailed look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of molecules, known as ion channel proteins, that allow signals to pass between neurons.

The results reveal an important role for the sugar molecules in such proteins.

“Our studies fill a major gap in the field and set a new paradigm,” said Lin Chen, associate professor of molecular and computational biology at USC.

Many existing theories, which do not consider sugar’s role, are probably incomplete, Chen said.

The debate over how signals pass from the outside of a cell to the inside is a long-standing one.

Some researchers had suggested that when a chemical such as nicotine binds to an ion channel protein on the cell surface, the protein starts a “conformational wave” that propagates a signal through the protein body to the cell membrane, Chen said.

But the molecular basis of such a wave in nAChR or any other protein has not been clearly established.

Instead, the Chen group’s study of crystal structure suggested a simple mechanical role for sugar molecule
'"/>

Source:University of Southern California


Page: 1 2

Related biology news :

1. Successful lung cancer surgery not enough to break nicotine dependence in many smokers
2. Nicotine triggers the same brain reward circuitry as opiates
3. Prenatal nicotine exposure reduces breathing response of newborns...
4. Nicotine exposure during development leads to hearing problems
5. Blood test predicts success of quitting smoking using the nicotine patch
6. Dissecting the machinery of nicotines reward
7. Smokers invite to test vaccine against nicotine addiction
8. New research identifies gene important for nicotines effects on the brain
9. Re-analysis of cigarettes confirms tobacco companies increased addictive nicotine 11 percent
10. Mechanism of nicotines learning effects explored
11. Children of smokers have more than 5 times higher levels of a nicotine toxin
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nicotine rush hinges sugar neurons

(Date:12/11/2014)... 2014  That blood pressure plays a role in human ... the medical term for high blood pressure – was first ... inflatable cuff that,s used in measuring blood pressure was invented ... new about hypertension, its triggers and its effects. In fact, ... and the best ways to treat it. For ...
(Date:12/10/2014)... Dec. 9, 2014  Wake Forest Baptist Medical Center today ... its School of Medicine. Funding for this $50 million ... that will be publicly launched next summer. ... the former 60 series R.J. Reynolds Tobacco Company complex, ... will begin immediately with plans to be ready to ...
(Date:12/5/2014)... 2014 Increased emphasis on product quality, ... testing and inspection technologies. The convergence of industries ... range of innovative test solutions. This trend is ... which is generally more inclined towards communication, media ... strategies of test equipment vendors will cater to ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4
... wife, Elizabeth, have made a $5 million gift to ... Adult Stem Cell Research at the University of Notre ... endowed professorships in adult and all forms of non-embryonic ... the field of stem cell research and enhance the ...
... who have each been assigned a wetland plant or animal ... their assigned plant or animal interacts with in some way. ... describes an event that affects one "organism." That "organism" tugs ... tug on their strings in turn. The lesson is ...
... from Ludwig-Maximilians-Universitt (LMU) in Munich have identified an enzyme ... essential for bacterial pathogenicity. Because it shows no similarity ... target for development of novel antimicrobial drugs. ... that these strains become pathogenic only when an enzyme ...
Cached Biology News:Notre Dame establishes professorships in adult stem cell research 2Notre Dame establishes professorships in adult stem cell research 3Foundational concept of ecology tested by experiment 2Foundational concept of ecology tested by experiment 3Foundational concept of ecology tested by experiment 4
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Jan. 28 Kendle (Nasdaq: KNDL ), ... Chairman and Chief Executive Officer Candace Kendle, PharmD,will ... conference,will be held at the Langham Hotel in ... Wednesday, Jan. 30 at 1:30 p.m. Eastern Time., ...
... Inc., a clinical,stage biopharmaceutical company developing novel multi-component ... present at the,Wachovia 2008 Healthcare Conference in Boston, ... Among the topics of the presentation will ... developments, including Phase III development,activities related to its ...
... 28 Campbell Alliance, the leading,management consulting firm ... that Nader Naeymi-Rad, Senior,Vice President of the firm,s ... Summit Europe. The event will be held on ... in London, England., Mr. Naeymi-Rad,s presentation, titled ...
Cached Biology Technology:Kendle to Present at the Wachovia 2008 Healthcare Conference 2Campbell Alliance Brand Management Practice to Discuss Managing Launch Logistics at the EyeForPharma Oncology Summit 2
... The lyophilization stabilizer is designed ... process and for long-term storage. ... toxic ingredients. It is a ... pH 7.2, and is superior to ...
... coating stabilizer is designed for stabilizing ... and antibodies for immunoassay development. ... during the coating and drying process ... It can also works as a ...
... Clinical is Tecans open platform for clinical ... safety and performance in the clinical diagnostic ... by flexible barcode reading and sample traceability ... the system complies with the IVD-Directive* established ...
... the smallest thermal cyclers on the market, which ... 0.5ml (20 samples) or 0.2ml microtube (25 samples) ... and cooling rate of 3.6C/sec and 2.0C/sec respectively ... Fast track programming with new quick dial facility ...
Biology Products: