Navigation Links
Newts which regrow their hearts

When a newt loses a limb, the limb regrows. What is more, a newt can also completely repair damage to its heart. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now started to decode the cellular mechanisms in this impressive ability to regenerate and have discovered the remarkable plasticity of newt heart cells. As mammals, and therefore also humans, do not have this ability, the findings could contribute to new cell therapies for patients with damaged organs (Journal of Cell Science, 2006).

The red-spotted newt, Notophthalmus viridescens, is a favourite animal of the researchers working with Thomas Braun in Nauheim. This amphibian comes from the wetlands of North America, but it also feels quite at home in the Institute’s aquaria. It is a small animal that scientists find interesting for a particular reason: whereas humans cannot regenerate damaged heart muscle adequately after a heart attack and the destroyed muscle tissue scars over instead, following damage, a newt’s heart can be completely repaired and the organ’s function can be completely restored.

The key to this ability to regenerate are the heart muscle cells themselves. When a newt’s heart sustains damage, its cells can lose their characteristic properties; they can dedifferentiate. The researchers were able to show that proteins typical of heart muscle cells - the heavy myosin chain and various troponins - were dramatically down-regulated in this process. At the same time, the cells embark on massive cell division to build up new heart muscle. It takes around two weeks for the heart function to be restored in the newt. The data shows that at this point the expression of the muscle-specific proteins is again normal, i.e. the cells have differentiated again, and have regained their characteristic properties.

The researchers isolated the heart muscle cells and cultured them. In most of the cells, Braun and his colleagues were able to
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2

Related biology news :

1. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
2. Overbearing colored light may reveal a second mechanism by which birds interpret magnetic signals
3. Bacteria which sense the Earths magnetic field
4. Researchers discover which organs in Antarctic fish produce antifreeze
5. First-ever genomic test predicts which lung cancer patients need chemotherapy to live
6. Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease
7. Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates
8. Killing the messenger RNA -- But which one?
9. Scientists discover stage at which an embryonic cell is fated to become a stem cell
10. Researchers find molecule that inhibits regrowth of spinal nerve cells
11. Ultrasound may help regrow teeth
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Newts which regrow their hearts

(Date:8/19/2014)... It,s not a lemur. It,s not an African Bush Baby ... tiny, adorable and downright "cool" primate from Southeast Asia. , ... with," said Rafe Brown, curator-in-charge at the University of Kansas, ... extremely cute, furry body; a long tail with a furry ... tips that look a bit like the disks on the ...
(Date:8/19/2014)... a new implantable tissue scaffold coated with bone growth ... When applied to bone injuries or defects, this coated ... that looks and behaves just like the original tissue. ... dramatic improvement over the current standard for treating bone ... the patient,s body a painful process that does ...
(Date:8/19/2014)... 19, 2014 ) -- Scientists at the Houston Methodist ... and transfer single cells using a pipette -- a ... this engineering feat and preliminary test results in a ... Chemical Society . , "Studying single cells and their ... research," said nanomedicine department. faculty member Lidong Qin, Ph.D., ...
Breaking Biology News(10 mins):Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Engineering new bone growth 2Engineering new bone growth 3Moving single cells around -- accurately and cheaply 2
... Canadian agriculture is faced with great opportunities, but ... expert panel convened by the Council of Canadian ... in Canada can be more sustainably managed by ... management strategies, adopting effective governance mechanisms, and harnessing ...
... Feb. 26, 2013   Althea Technologies, Inc. , ... services, and Profectus BioSciences Inc , a ... of a manufacturing supply agreement for plasmid DNA ... quantities of cGMP (current Good Manufacturing Practice) manufactured ...
... of Kansas researchers have found that the infants of mothers ... DHA during pregnancy weighed more at birth and were less ... 34 weeks gestation than infants of mothers who were given ... the dietary supplement during pregnancy. Susan CarlsonThe results are ...
Cached Biology News:Report: 'Water and Agriculture in Canada: Towards Sustainable Management of Water Resources' 2Althea Technologies & Profectus BioSciences Sign Manufacturing Agreement For Plasmid DNA Production 2Althea Technologies & Profectus BioSciences Sign Manufacturing Agreement For Plasmid DNA Production 3Prenatal DHA reduces early preterm birth, low birth weight 2
(Date:8/19/2014)... , Aug. 19, 2014 Research and Markets ... Supplies - Global Strategic Business Report" report to their offering. ... and Tissue Culture Supplies in US$ Thousands by the following Product ... comprehensive analytics for the US, Canada , ... Asia-Pacific , and Latin America . Annual ...
(Date:8/19/2014)... Cellgen Diagnostics today ... fund a corporate lab for its genetic-based medical ... is a critical component in the move from ... implementation of personalized medicine – a more predictive, ... Indiegogo contributions will support Cellgen’s intent to develop ...
(Date:8/19/2014)... 19, 2014 Robin Williams’ passing is ... take on an individual. Symptoms range from slowness ... problems swallowing and severe depression. Parkinson’s disease progressively ... of dopamine producing neurons of the brain. As ... that slowly and progressively gets worse, they look for ...
(Date:8/19/2014)... 19, 2014 Research and ... the "Spectroscopy Equipment and Accessories - ... their offering. This report ... and Accessories in US$ Thousands by the ... Raman Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) ...
Breaking Biology Technology:Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2
... (PHPG) today reported its consolidated, audited, financial,results for its ... in fiscal year 2007 were a record at $15,100,000 ... the year was our,highest ever at $17,802,000 as was ... 2006, respectively., Pre-tax income for the year was ...
... March 31 BioMarin,Pharmaceutical Inc. (Nasdaq and SWX: ... marketing and distribution partner in Japan, has,received approval ... Japanese Ministry of Health, Labour and Welfare,(MHLW) for ... MPS,VI)., "We are proud to work with ...
... Initial Proceeds to be Used for Marketing in ... -- China Kangtai,Cactus Biotech Inc. (the "Company") (OTC ... and marketer of a,variety of cactus-based consumer products ... into an equity purchase agreement with T Squared,Investments ...
Cached Biology Technology:Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 2Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 3Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 4Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 5Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 6Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 7Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 8Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 9Naglazyme Approved by Japanese Ministry of Health 2Naglazyme Approved by Japanese Ministry of Health 3Naglazyme Approved by Japanese Ministry of Health 4China Kangtai Cactus Biotech, Inc. Obtains $500,000 Equity Financing 2
Phospho-FAK (Tyr576/577) Antibody...
... Anti-Natural Killer Cell Receptor-P1, ... Immunogen: Hybridoma produced ... from BALB/c mice immunized (BALB/c ... (LAK) cells and mouse myeloma ...
... to Yersinia pestis This antibody ... . Immunogen: Purified ... vaccine strain EV76. ... F1 capsular antigen. There is no ...
Rabbit polyclonal to ZFP200 ( Abpromise for all tested applications). Antigen: Synthetic peptide: CGKSFNHKTNLNKHER (Human) Entrez Gene ID: 7752 Swiss Protein ID: P98182...
Biology Products: