Navigation Links
Newts which regrow their hearts

When a newt loses a limb, the limb regrows. What is more, a newt can also completely repair damage to its heart. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now started to decode the cellular mechanisms in this impressive ability to regenerate and have discovered the remarkable plasticity of newt heart cells. As mammals, and therefore also humans, do not have this ability, the findings could contribute to new cell therapies for patients with damaged organs (Journal of Cell Science, 2006).

The red-spotted newt, Notophthalmus viridescens, is a favourite animal of the researchers working with Thomas Braun in Nauheim. This amphibian comes from the wetlands of North America, but it also feels quite at home in the Institute’s aquaria. It is a small animal that scientists find interesting for a particular reason: whereas humans cannot regenerate damaged heart muscle adequately after a heart attack and the destroyed muscle tissue scars over instead, following damage, a newt’s heart can be completely repaired and the organ’s function can be completely restored.

The key to this ability to regenerate are the heart muscle cells themselves. When a newt’s heart sustains damage, its cells can lose their characteristic properties; they can dedifferentiate. The researchers were able to show that proteins typical of heart muscle cells - the heavy myosin chain and various troponins - were dramatically down-regulated in this process. At the same time, the cells embark on massive cell division to build up new heart muscle. It takes around two weeks for the heart function to be restored in the newt. The data shows that at this point the expression of the muscle-specific proteins is again normal, i.e. the cells have differentiated again, and have regained their characteristic properties.

The researchers isolated the heart muscle cells and cultured them. In most of the cells, Braun and his colleagues were able to demonstrate the existence of a protein called Phospho-H3. This protein is a marker for the G2 phase of the cell cycle and indicates that the newt heart regenerates without the involvement of stem cells. It also seems that the heart regeneration does not create typical wound healing tissue, called a blastema. Braun explains this finding: "The heart only has a relatively small number of different cell types. This could be a reason why the regeneration of heart tissue does not require a blastema." The researchers in Bad Nauheim found no indication that stem cells were involved in repairing newt hearts.

he process of regenerating lost extremities is different. Unlike in the process with the heart, newts develop a blastema in this case. Blastema cells have certain characteristics in common with stem cells, such as the development into different cell types. The cell biologists in Bad Nauheim injected isolated heart muscle cells into a newt’s leg that was regrowing after amputation. In this environment, the cells began to de-differentiate, as they did in the heart. However, this did not happen when they were injected into an undamaged extremity. Again, the researchers registered the very rapid loss of heart muscle-specific proteins.

"We suspect that the signal for the de-differentiation comes from the area where the wound is healing and the cells communicate with each other," explains Braun. These signals could be transmitted via certain enzymes, for example. An enzyme of this nature - focal adhesion kinase -, which plays a part in the transmission of signals in the cells, is phosphorylated in the transplanted cells and is thus active. The Max Planck researchers in Bad Nauheim hope that better understanding of the molecular issues involved in regeneration in the newt will open up new possibilities for the repairing human patients’ damaged hearts.
'"/>

Source:Max-Planck-Gesellschaft


Related biology news :

1. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
2. Overbearing colored light may reveal a second mechanism by which birds interpret magnetic signals
3. Bacteria which sense the Earths magnetic field
4. Researchers discover which organs in Antarctic fish produce antifreeze
5. First-ever genomic test predicts which lung cancer patients need chemotherapy to live
6. Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease
7. Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates
8. Killing the messenger RNA -- But which one?
9. Scientists discover stage at which an embryonic cell is fated to become a stem cell
10. Researchers find molecule that inhibits regrowth of spinal nerve cells
11. Ultrasound may help regrow teeth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)...  GCE Solutions, a global clinical research organization (CRO), announces the ... on October 4, 2017. Shadow is designed to assist medical writers ... 0070 of the European Medicines Agency (EMA) in meeting the requirements ... ... ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017  IBM ... in dairy research, today announced a new collaboration using ... the chances that the global milk supply is impacted ... project, Cornell University has become the newest academic institution ... Chain, a food safety initiative that includes IBM Research, ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and ... of osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular ...
(Date:10/10/2017)... ... October 10, 2017 , ... For ... has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled ... Volunteer Experience from US2020. , US2020’s mission is to change the trajectory of ...
(Date:10/10/2017)... Calif. , Oct. 10, 2017 SomaGenics ... from the NIH to develop RealSeq®-SC (Single Cell), expected ... for profiling small RNAs (including microRNAs) from single cells ... Program highlights the need to accelerate development of approaches ... "New techniques for measuring levels ...
Breaking Biology Technology: