Navigation Links
Newts which regrow their hearts

When a newt loses a limb, the limb regrows. What is more, a newt can also completely repair damage to its heart. Scientists at the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now started to decode the cellular mechanisms in this impressive ability to regenerate and have discovered the remarkable plasticity of newt heart cells. As mammals, and therefore also humans, do not have this ability, the findings could contribute to new cell therapies for patients with damaged organs (Journal of Cell Science, 2006).

The red-spotted newt, Notophthalmus viridescens, is a favourite animal of the researchers working with Thomas Braun in Nauheim. This amphibian comes from the wetlands of North America, but it also feels quite at home in the Institute’s aquaria. It is a small animal that scientists find interesting for a particular reason: whereas humans cannot regenerate damaged heart muscle adequately after a heart attack and the destroyed muscle tissue scars over instead, following damage, a newt’s heart can be completely repaired and the organ’s function can be completely restored.

The key to this ability to regenerate are the heart muscle cells themselves. When a newt’s heart sustains damage, its cells can lose their characteristic properties; they can dedifferentiate. The researchers were able to show that proteins typical of heart muscle cells - the heavy myosin chain and various troponins - were dramatically down-regulated in this process. At the same time, the cells embark on massive cell division to build up new heart muscle. It takes around two weeks for the heart function to be restored in the newt. The data shows that at this point the expression of the muscle-specific proteins is again normal, i.e. the cells have differentiated again, and have regained their characteristic properties.

The researchers isolated the heart muscle cells and cultured them. In most of the cells, Braun and his colleagues were able to
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2

Related biology news :

1. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
2. Overbearing colored light may reveal a second mechanism by which birds interpret magnetic signals
3. Bacteria which sense the Earths magnetic field
4. Researchers discover which organs in Antarctic fish produce antifreeze
5. First-ever genomic test predicts which lung cancer patients need chemotherapy to live
6. Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease
7. Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates
8. Killing the messenger RNA -- But which one?
9. Scientists discover stage at which an embryonic cell is fated to become a stem cell
10. Researchers find molecule that inhibits regrowth of spinal nerve cells
11. Ultrasound may help regrow teeth
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Newts which regrow their hearts

(Date:6/15/2015)... According to a new market research report ... Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... Natural Language Processing Market is expected to grow to ... forecast period 2015-2020. Browse 65 market ...   through 155 P ages and in-depth TOC ...
(Date:6/11/2015)... RESTON, Va. , June 11, 2015 /PRNewswire/ ... authentication technology, announced today that its IdentityX Mobile ... FIDO (Fast IDentity Online) Alliance is an industry ... with open standards for simpler, stronger authentication.  In ... services must pass a rigorous series of tests ...
(Date:6/8/2015)... -- Trovagene, Inc. (NASDAQ: TROV ), a developer of cell-free ... Cancer Monitoring SM platform will be presented at the ... San Diego, CA on June 11-12 , ... Genomics and Cancer Therapy in Salt Lake ... "We continue to advance our clinical programs and present data ...
Breaking Biology News(10 mins):Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 2Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 3Clinical Data Featuring Trovagene's Urine-Based Liquid Biopsy Platform to be Presented at Two Upcoming Medical Conferences 4
... the National Institute of Standards and Technology (NIST) ... have developed reliable methods based on DNA analysis ... spores after prolonged storage. The techniques and data ... standard for anthrax detection and decontamination. Bacillus ...
... blast shook the Pacific atoll of Bikini, the corals are ... extinct. These are the findings of a remarkable investigation ... Hawaii and the Marshall Islands. The expedition examined the ... One of the most interesting aspects is that ...
... International Presence for Acclaimed Provider of ... Algorithms and Object Recognition Technologies, VILNIUS, ... high-precision biometric identification technologies, today,announced the change ... (http://www.neurotechnology.com ). Neurotechnology was founded in 1990 ...
Cached Biology News:NIST, Army researchers pave the way for anthrax spore standards 2Bikini corals recover from atomic blast 2Bikini corals recover from atomic blast 3Neurotechnologija Changes Corporate Name to Neurotechnology 2
(Date:6/29/2015)... KS (PRWEB) , ... June 29, 2015 , ... ... PATENT 7736892 B2. Under the terms of the agreement, MediVet will acquire the ... Stem Cells (UCMSCs). MB-007 is currently in pre-clinical development as a potential next-generation ...
(Date:6/29/2015)...  Neuralstem, Inc. (NYSE MKT: CUR), a biopharmaceutical company ... and cell therapy treatments for central nervous system diseases, ... on the NASDAQ Capital Market under the symbol "CUR." ... the NYSE MKT until the market close on July ... expected to commence on July 13, 2015. ...
(Date:6/29/2015)... , June 29, 2015 ... and medical information products and services, today announced the ... According to the 2014 Journal Citation Reports® (JCR) published ... Impact Factors increase from 2013 to 2014, ahead of ... occupied the top rank in 62 subject categories, up ...
(Date:6/26/2015)... , June 26, 2015  A San Francisco ... products made with synthetic rhino horn: beer in ... Vietnam . In response to the emerging ... manufacture, marketing and sale of synthetic rhino horn.  ... and Save the Rhino International (SRI) released ...
Breaking Biology Technology:MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2
... wonks out there, time to listen up. Heres something ... a leading international survey research and consulting firm, estimates ... billion a year in productivity losses! The Gallup ... current percentage of employees who are actively disengaged at ...
... s recent acquisition of Network Engineering Associates ... strength in the key technology of voice over Internet ... bought the Wausau-based IT firm last week for an ... of NEAs 22 employees. , ,"The combination will allow ...
... projects still late? Do they continue to cost too much? ... probably yes. , ,The point of this series was to ... you learn new things every day. You continuously improve. You ... Youve learned the latest techniques. The same is true for ...
Cached Biology Technology:The high cost of employee disengagement 2The high cost of employee disengagement 3Berbee acquisition could expand VoIP in Wisconsin 2Project Performance: Is your project late? Over budget? 2Project Performance: Is your project late? Over budget? 3
Request Info...
Bovine Serum Albumin Heat Shock Diagnostic Grade Powder...
... provides the premium quality siRNAs you need ... can be readily ordered online by providing ... by providing the sense and antisense siRNA ... Validated and Silencer Pre-designed ...
... siRNA service provides the premium quality siRNAs ... Custom siRNAs can be readily ordered online ... sequence, or by providing the sense and ... Silencer Validated and Silencer ...
Biology Products: