Navigation Links
Newly discovered protein an important tool for sleeping sickness research

Sixty million people in 36 countries of sub-Saharan Africa are threatened daily by a deadly parasitic disease known as African sleeping sickness. The disease is caused by organisms called trypanosomes, which are spread by the tsetse fly. African sleeping sickness affects approximately 500,000 people in sub-Saharan Africa, a quarter of whom will die this year. Because the trypanosome has an exceptional genetic strategy for evading the human immune system and resisting treatment, the current treatment for this disease is melarsopal, an antiquated drug with terrible side effects, including death.

In the February issue (Volume 17, Issue 3) of the journal Molecular Cell, scientists in the Marine Biological Laboratory's (MBL's) Josephine Bay Paul Center for Comparative Molecular Biology and Evolution report their discovery of a protein called JBP2, which will help them test their hypothesis that a uniquely modified DNA base called base J is a key component of the trypanosome's mechanism for evading the immune system. If the hypothesis is correct, it will bring scientists closer to developing a more effective drug for treating African sleeping sickness.

The trypanosome evades the human immune system because it is coated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies the human immune system made to fight the original antigen, thus assuring the long-term survival of these parasites within their hosts. The trypanosome has approximately 1,000 different VSG genes, but only expresses one at a time while the others are somehow silenced. This genetic trick, called antigenic variation, has severely limited sleeping sickness treatment options and essentially ruled out the possibility of a vaccine.

MBL trypanosome experts in Robert Sabatini's lab hypothes
'"/>

Source:Marine Biological Laboratory


Page: 1 2

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly discovered pathway might help in design of cancer drugs
5. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
6. Newly discovered genetic disease sheds light on bodys water balance
7. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
8. Newly recognized gene mutation may reduce seeds, resurrect plants
9. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
10. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
11. Newly identified mechanism helps explain why people of African descent are more vulnerable to TB
Post Your Comments:
(Date:9/16/2014)... The risk of severe maternal morbidity amongst women ... suggests a new study published today (17 September) ... and Gynaecology . , Australians generally enjoy high ... that health disparities exist, in particular between indigenous ... aimed to explore the independent impact of socioeconomic ...
(Date:9/16/2014)... 36 Pit Fire began on September 13, 2014. The ... It is currently over 2,300 acres in size and is ... 36 Pit Fire was calm Monday night due to higher ... an anchor point and beginning to construct a fireline on ... following resources are working on the fire: , 7 20-person ...
(Date:9/16/2014)... impact that spelled doom for the dinosaurs 66 million ... to a much greater extent than their deciduous peers, ... results are published in the journal PLOS Biology ... trove of thousands of fossilized leaves of angiosperms ... able to reconstruct the ecology of a diverse plant ...
Breaking Biology News(10 mins):New study examines the impact of socioeconomic position & maternal morbidity in Australia 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 3Meteorite that doomed dinosaurs remade forests 2Meteorite that doomed dinosaurs remade forests 3Meteorite that doomed dinosaurs remade forests 4
... peas in a pod may not be so friendly when planted ... once separated may treat the former conjoined twin as an alien ... at how plants determine who is a competitor when competing with ... in plant ecology. "There is no reason for roots to fight ...
... wake of Katrina, the public health threats from infectious ... from milder, more common infections rather than exotic diseases. ... hygiene measures and a little common sense. , "Deadly ... break out after hurricanes and floods in areas where ...
... that once characterized expansive tracts of tropical rainforest gets ... how big a role these winged gardeners play is ... Chicago and several Latin American universities are about to ... in Mexico's gulf coast state of Veracruz. , Henry ...
Cached Biology News:Prozac for future Plants on Mars 2Hurricane aftermath: Infectious disease threats from common, not exotic, diseases 2Birds and bats sow tropical seeds 2Birds and bats sow tropical seeds 3
(Date:9/17/2014)... NASA’s MESSENGER has just celebrated its 10 year ... have one of its latch valves, V27200-818, operating onboard ... investigation of the planet Mercury. It is only the ... provided a vast amount of information and images of ... utilize solenoids that also include permanent magnets to maintain ...
(Date:9/16/2014)... “Nature has developed, very cleverly, some lessons ... in optical design,” said Joseph Shaw, director of the ... explore surfaces and structures at the nanoscale, we’ll discover ... San Diego in August during a conference called “ ... by Shaw and Rongguang Liang of the University of ...
(Date:9/16/2014)...  Biocom, the association representing the Southern ... th Annual National Health Information Technology Week, which ... improving our health care system. " ... world,s most vibrant hubs for health IT and digital ... genomic testing to remote patient monitoring," said Joe ...
(Date:9/16/2014)... Rice University scientists who created a deicing film for ... as a transparent coating for glass. , The ... colleagues could keep glass surfaces from windshields to skyscrapers ... to radio frequencies (RF). , The technology was ... Applied Materials and Interfaces . , The ...
Breaking Biology Technology:Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5Biocom Recognizes National Health IT Week 2Nanoribbon film keeps glass ice-free 2
... Inc.,(Nasdaq: HOLX ) today announced the successful completion ... Tech Corp., for all,outstanding shares of Third Wave Technologies, ... per share in cash., The subsequent offering period ... July 23, 2008. The initial tender offer period expired,at ...
... 24 Cara Therapeutics, Inc.,announced today that ... additional funding,to its original $24 million Series ... round was led by new investor, Devon ... Previous investors participating,in the round included; Ascent ...
... Md., July 24 United,Therapeutics Corporation (Nasdaq: ... 2008 second quarter financial results before the open ... Therapeutics will host a half-hour teleconference on Thursday,July ... teleconference is accessible,by dialing 1-800-603-1777, with international callers ...
Cached Biology Technology:Hologic Completes Cash Tender Offer for Third Wave Technologies, Inc. 2Hologic Completes Cash Tender Offer for Third Wave Technologies, Inc. 3Hologic Completes Cash Tender Offer for Third Wave Technologies, Inc. 4Cara Therapeutics Secures $12.3 Million in Series C Extension Financing 2
... This personal-sized Thermal Cycler is the ideal ... a full range of PCR applications. ... affordable price. Save lab space without ... software. Industry-Standard PCR Technology You Can ...
... Salmonella typhimurium The genus Salmonella is a ... composed of Gram-negative bacilli that are facultative and ... "H" or flagellar antigen (phase 1 & 2), ... LPS moiety) and the "Vi" or capsular antigen ...
... With 36 mg/L sodium pyruvate, 50 ... 1000 mg/L glucose, calcium chloride, and magnesium ... solution (BSS) in tissue culture is generally ... In 1885, Sydney Ringer developed a solution ...
... micro 1 is a dramatic breakthrough in accurate, ... with 10nL resolution, the micro 1 has unique ... And, the micro 1 never needs re-calibration as ... Screen programming on an LCD Display , Graphical ...
Biology Products: