Navigation Links
Newly discovered pathway might help in design of cancer drugs

Johns Hopkins chemists have discovered a new way to sabotage DNA's ability to reproduce, a finding that could eventually lead to the development of new anti-cancer drugs and therapies.

The method could enable future doctors to target treatment more precisely, rather than directing chemotherapeutic medication or radiation to tumors through a scattershot approach, said Marc Greenberg, a chemistry professor in the university's Zanvyl Krieger School of Arts and Sciences, who will present his team's findings on March 14 at the 229th American Chemical Society Meeting in San Diego.

"What we did was to identify a way to create a very damaged form of DNA that is often more deadly to the cell than other types of damage," said Greenberg. "That's how many anti-tumor medications -- medications such as mitomycin c -- work: They kill off tumors by linking up with the cancer cells' DNA and sticking its genetic code together so it dies. Our discovery takes that a step further, establishing that there is a way to efficiently create this type of damage by modifying the DNA itself."

In the lab, Greenberg and his team used organic chemistry to create a synthetic, double-stranded DNA with special chemical characteristics and exposed it to long wavelength light that selectively switches on the DNA damage process.

He said that the synthetic DNA is very similar to that which is produced when cells are exposed to radiation, with one exception: Greenberg's team's DNA was damaged at only one place on its chain, allowing the researchers to study it and learn about that particular chemical pathway in detail.

"Exposing DNA to radiation is like hitting a fine piece of crystal stemware with a hammer. It shatters, and looking for a particular chemical pathway is like looking for a needle in a haystack," the chemist explained. "What we did was more like carrying out a precision attack. It let us get a closer look."


'"/>

Source:Johns Hopkins University


Page: 1

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. Newly discovered protein an important tool for sleeping sickness research
6. Newly discovered genetic disease sheds light on bodys water balance
7. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
8. Newly recognized gene mutation may reduce seeds, resurrect plants
9. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
10. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
11. Newly identified mechanism helps explain why people of African descent are more vulnerable to TB
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)...  GCE Solutions, a global clinical research organization (CRO), announces the ... on October 4, 2017. Shadow is designed to assist medical writers ... 0070 of the European Medicines Agency (EMA) in meeting the requirements ... ... ...
(Date:6/30/2017)... , June 30, 2017 Today, ... developer and supplier of face and eye tracking ... Featured Product provider program. "Artificial ... innovative way to monitor a driver,s attentiveness levels ... from being able to detect fatigue and prevent ...
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which ... video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). ...
(Date:10/7/2017)... ... October 06, 2017 , ... Phase ... metagenome deconvolution product, featuring the first commercially available Hi-C kit. Researchers can ... Hi-C metagenome deconvolution using their own facilities, supplementing the company’s full-service ProxiMeta ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... the healthcare and technology sector at their fourth annual Conference where founders, investors, ... inspiring speakers and the ELEVATE pitch competition showcasing early stage digital health and ...
Breaking Biology Technology: