Navigation Links
Newly discovered killer cell fights cancer

A mouse immune cell that plays dual roles as both assassin and messenger, normally the job of two separate cells, has been discovered by an international team of researchers from the United States and France. The discovery has triggered a race among scientists to find a human equivalent of the multitasking cell, which could one day be a target for therapies that seek out and destroy cancer.

"In the same way that intelligence and law enforcement agencies can face deadly threats together instead of separately, this one cell combines the ability to kill foreign pathogens and distribute information about that experience," says Drew Pardoll, M.D., Ph.D., the Seraph Professor of Oncology at the Johns Hopkins Kimmel Cancer Center.

"We think this hybrid cell speeds up immune reactions and makes the system more efficient," adds Pardoll, whose findings are reported in the February issue of Nature Medicine.

The Hopkins investigators speculate that the hybrid, dubbed "IKDC" for interferon-producing killer dendritic cell, has been missed by cancer biologists because it is rare, making up one-tenth of cells in the spleen with similar features, such as other dendritic cells, according to Frank Housseau, Ph.D., research associate at Hopkins' Kimmel Cancer Center and member of Pardoll's immunology laboratory.

Most of the immune system typically works through a web of cross-talk and signaling among a variety of cells. One of the first immune cells that invading bacteria or cancer cells - both of which carry antigens that alert the immune system - may encounter is a natural killer (NK) cell. As its name implies, NK cells deliver a deadly blow by poking holes in the invader's outer membrane. Then, NK cells secrete molecules that reach other immune cells, including dendritic cells, known as the main messenger for the immune system. Dendritic cells spread "look here" information about foreign invaders to other immune cells, but do not actually kill
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly discovered pathway might help in design of cancer drugs
5. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
6. Newly discovered protein an important tool for sleeping sickness research
7. Newly discovered genetic disease sheds light on bodys water balance
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
11. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Newly discovered killer cell fights cancer

(Date:7/11/2014)... from Ume University, Sweden, have explored two different ... reaction sequence leading to the formation of oxygen ... published in the scientific journal Nature Communications ... present day synthetic catalysts for water oxidation, which ... for the direct storage of solar energy in ...
(Date:7/11/2014)... that transplantation of mesenchymal stem cells can stimulate neurogenesis ... of Alzheimer,s disease (AD) and improve tissue and function ... are reported on the therapeutic effect of adipose-derived stem ... the effect on oxidative injury and neurogenesis in the ... team, School of Life Sciences, Tsinghua University, China transplanted ...
(Date:7/11/2014)... Evidence exists that cannabinoid receptor type 1 ... Ca2+ influx, and reduce neurotransmitter release. However, ... 1 can increase extracellular Ca2+ influx and ... his team, Tongji Hospital Affiliated to Tongji ... Technology, China used whole cell voltage-clamp and ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... electronic skin, or e-skin, and electronic eye implants or ... Researchers with Berkeley Lab and the University of California ... of carbon nanotubes and silver nanoparticles similar to the ... e-whiskers respond to pressure as slight as a single ...
... of men,s bones - but only if they marry when they,re ... In a study published online in the peer-reviewed journal Osteoporosis ... were younger than 25 had lower bone strength than men who ... In addition, men in stable marriages or ...
... climate. Take, for example, the Mayans, who, throughout the ... their major ceremonial centers after a series of multi-year droughts, ... forests. Much later, in the late 20th century, frequent droughts ... migrate from the dry north to the wetter south where ...
Cached Biology News:E-whiskers 2Guys: Get married for the sake of your bones, but wait until you're 25 2Guys: Get married for the sake of your bones, but wait until you're 25 3Princeton model anticipates ecological impacts of human responses to climate 2Princeton model anticipates ecological impacts of human responses to climate 3
(Date:7/14/2014)... 14, 2014 Throughout this past ... the clinical trials space, representing 38 countries globally, ... entitled “Optimizing Patient Participation in Clinical Trials. Attract. ... with internationally renowned R&D expert, Ken Getz, of ... Reinventing Drug Development through Patient Centricity. , Throughout ...
(Date:7/13/2014)... 2014 Deep Research Report on Global and ... study on the current state of the Nano Silver ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Transfection Technology Market - Global Industry Analysis, Size, ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... introduce nucleic acids (either DNA or RNA) into cells. ... mutation of cancer cells and protein metabolism by affecting ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
Breaking Biology Technology:Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 52014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... , for routine high fidelity amplification of up to 3.5 kb , ... 100 units , Cat. No. 1 664 955 ... , , Description , , , ... archaebacterium Pyrococcus woesei. The enzyme has a molecular weight of , ...
... , for routine amplification of up to 3 kb genomic DNA ... , , , , , ... contains 10 vials of 2x concentrated PCR reaction , mix (Taq ... dNTPs) plus water PCR grade (for dilution), sufficient for 100 , ...
... for amplification of up to 5 kb targets from genomic DNA ... , , , , , ... concentrated High Fidelity PCR Master contains all necessary , reagents ... a unique enzyme blend of Taq DNA Polymerase and Pwo DNA Polymerase[a thermostable , ...
Cached Biology Technology:Pwo DNA Polymerase 2Pwo DNA Polymerase 3PCR Master 2PCR Master 3High Fidelity PCR Master 2