Navigation Links
Newly discovered behavior in cancer cells signals dangerous metastasis

The most aggressively malignant cancer cells have a "toggle switch" that enables them to morph into highly mobile cells that invade other tissues and then nest comfortably in their new surroundings, a new study in rats suggests.

This picture of how cancer cells shift between two alternating states -- travelers and nesters -- represents a new understanding of how cancer metastasizes, or spreads to other parts of the body, said the Duke Comprehensive Cancer Center researchers who conducted the study.

"Understanding this toggle switch might ultimately enable scientists to find ways to stop cells from metastasizing, which is the most deadly trait of cancer," said the study's lead investigator, Mariano Garcia-Blanco, M.D., Ph.D., professor of molecular genetics and microbiology.

The researchers will publish their findings in the Sept. 19, 2006, issue of the journal Proceedings of the National Academy of Sciences, now available on line. The research was funded by the National Cancer Institute.

Until now, scientists have believed that cancer cells must transform permanently from stationary epithelial cells into migratory mesenchymal cells in order to metastasize.

The Duke team discovered that highly malignant cells are equal parts epithelial and mesenchymal, transitioning between the two as their surroundings necessitate. The proteins that the cell produces dictate which way the cell shifts.

In a classic example of survival of the fittest, a cancer cell's ability to toggle between epithelial and mesenchymal enables the most malignant cells to aggressively invade and then peacefully adapt in unfamiliar territory, the scientists said.

"The prevailing notion has been that the more mesenchymal the cancer cells, the more mobile and metastatic they would be," Garcia-Blanco said. "In reality, aggressive cancer cells are not homogenous, but are extremely versatile in their ability to adapt as their survival needs shift."


'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. Newly-discovered class of genes determines ?and restricts ?stem cell fate
2. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
3. Newly Discovered Compound Blocks Known Cancer-Causing Protein
4. Newly discovered pathway might help in design of cancer drugs
5. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
6. Newly discovered protein an important tool for sleeping sickness research
7. Newly discovered genetic disease sheds light on bodys water balance
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. Newly discovered birdlike dinosaur is oldest raptor ever found in South America
11. Fitting in: Newly evolved genes adopt a variety of strategies to remain in the gene pool
Post Your Comments:
(Date:8/31/2014)... fast and accurate tool to diagnose tuberculosis in ... developed test (TAM-TB assay) is the first reliable ... The test features excellent specificity, a similar sensitivity ... a blood test. The promising findings are a ... children, particularly in tuberculosis-endemic regions. , The study ...
(Date:8/31/2014)... busy attacking us, germs go after each other. But ... for the infected microbes: Sometimes viruses actually carry helpful ... its diet or better attack its own hosts. , ... system would robotically destroy anything it recognized as invading ... now revealed that one variety of the bacterial immune ...
(Date:8/31/2014)... diagnosis has changed very little. After taking a blood sample ... glass slide, stains it with a special dye, and looks ... disease. This approach gives an accurate count of how many ... disease severity but is not ideal because there is ... Singapore-MIT Alliance for Research and Technology (SMART) has now come ...
Breaking Biology News(10 mins):New tuberculosis blood test in children is reliable and highly specific 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3A new way to diagnose malaria 2A new way to diagnose malaria 3
... perennial wheat to be grown on any significant basis in ... Texas Agricultural Experiment Station plant pathologist., From wheat producers ... is finding a groundswell of interest as he begins planting ... wheat study., Rush obtained his initial perennial wheat seed ...
... Barbara, Calif.) -- By peering deep into evolutionary history, ... discovered the origins of photosensitivity in animals. ... the scientific journal PLoS ONE. The scientists studied the ... animals that have existed for hundreds of millions of ...
... convene for two days in Germany, Oct. 18-19, to ... foster better economic and social conditions in Africa through ... pledged in the declarations of the Gleneagles and Heiligendamm ... development. About 70 experts from nine African nations, ...
Cached Biology News:A wheat for all seasons -- and reasons 2A wheat for all seasons -- and reasons 3UCSB researchers discover the dawn of animal vision 2Improving science, technology in Africa is aim as G-8, African, UN experts convene in Berlin 2Improving science, technology in Africa is aim as G-8, African, UN experts convene in Berlin 3
(Date:8/28/2014)... research platform uses a laser to measure ... stress and heating, an approach likely to ... and batteries., This new technique, called nanomechanical ... and the surface stress of microscale structures ... the merits of surface-stress influence on mechanical ...
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... Fla. Exciting new work by a Florida State ... system that can take your temperature, emit white light, ... And, the molecule looks like a butterfly. , Biwu ... Biomedical Engineering in the FAMU-FSU College of Engineering, created ... but has continued to discover that his creation has ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 PrimeSource ... construction materials, selected SoundConnect to support ... cloud based audio and web conferencing platform GlobalMeet ... support PrimeSource’s employees’ needs. SoundConnect delivers award ... , PrimeSource Building Products will be utilizing ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2
... Florida in mid-October. Late in the month, Florida Governor Jeb ... negotiations to create and pass a bill creating a $369 ... for the Scripts Research Institute to focus on biotechnology research ... an example of a state that successfully attracted a private ...
... university, an emerging biotech industry, a well educated work force ... has a $3.2 billion budget deficit and a per capita ... below the national average in citizens with a 4-year degree, ... states. The current state of our economy presents a complex ...
... took huge strides last week. In fact, the technology ... mortals might use in everyday communications. , ,What's driving ... executive board rooms to the stuff of ordinary communications? ... the availability of low-cost, high-quality desktop video cameras; and ...
Cached Biology Technology:Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 2Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 3Florida: Investing Heavily in Biotechnology - Governor uses state funds to attract large biotech companies 4WARF Collaboration a Win-Win for Wisconsin 2WARF Collaboration a Win-Win for Wisconsin 3Video Conferencing for the Masses 2Video Conferencing for the Masses 3
MOUSE ANTI SIMIAN VIRUS 5 Immunogen: Simian virus 5...
... Serum • Beagle serum is collected from ... year of age Available Anticoagulants: ... N-06: K2EDTA N-08: Potassium ... Alsevers N-05: ACD N-07: ...
MOUSE ANTI BOVINE TROPONIN I...
Normal donkey serum collected from healthy normal donkeys....
Biology Products: