Navigation Links
Newfound roadblock to interferon effectiveness against malignant melanoma

Researchers have uncovered a significant contributing factor to interferon resistance of malignant melanoma cells. The finding represents a step forward in understanding the molecular events that govern the growth of this type of cancer and the changes in gene expression and cellular signaling that underlie resistance to established therapies.

Malignant melanoma is the deadliest form of skin cancer, and if not treated successfully, it can spread to affect the liver, lungs, or brain. Chemotherapy fights the disease with limited efficiency, and the use of interferon has become the most established immunotherapy for advanced-stage melanoma. However, melanoma tumors often develop a resistance to the drug, posing one of the major obstacles in the clinical treatment of this cancer.

Now Professor Manfred Schartl and Dr. Claudia Wellbrock, scientists at the University of W�rzburg, believe they have an explanation for how this interferon resistance is acquired. They have found that when a gene called STAT5 is too active in melanoma cells, it can counteract the anti-cancer effect of interferon. Interferon normally impedes the growth of cancer cells, whereas STAT5 is thought to act to promote cellular growth.

The new work, published by Professor Schartl and his colleagues in Current Biology, shows that interferon actually activates STAT5 in melanoma cells but that under normal conditions, this does not interfere with the inhibitory potential of the drug. However, when cancer cells posses too much STAT5 activity to begin with, the further activation of STAT5 function by interferon induces a mechanism that blocks the ability of the drug to effectively inhibit growth.

Confirming this initial finding, the researchers found that when they inhibited STAT5 in interferon-resistant melanoma cells, they were able to restore the effectiveness of interferon. This demonstrates the relevance of STAT5 and its contribution to the behavior of melanoma cells in th
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Hepatitis C responds best to combo of ribavirin and interferon, study concludes
2. Greasing interferons gears may pave way to greater therapeutic benefits, fewer side effects
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Man-made wetlands effectiveness similar to natural marsh
5. UCLA study assesses cost-effectiveness of Hepatitis B drugs
6. Structures of marine toxins provide insight into their effectiveness as cancer drugs
7. Test reveals effectiveness of potential Huntingtons disease drugs
8. Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
9. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
10. Bound for destruction: Ubiquitination protects against improper Notch signaling
11. Female sex hormones play a vital role in defense against sexually transmitted diseases
Post Your Comments:
(Date:4/23/2014)... of Public Health-Bloomington has bolstered the link between red ... association between heme iron, found only in meat, and ... that heme iron consumption increased the risk for coronary ... found between nonheme iron, which is in plant and ... study was published online ahead of print in the ...
(Date:4/23/2014)... Toronto Scarborough research shows that male black widow spiders ... a rare example of mate preference by male spiders. ... Emily MacLeod and Maydianne Andrade, a professor in UTSC,s ... studies and the wild that males overwhelmingly chose to ... black widows can tell whether a potential mate is ...
(Date:4/23/2014)... the likelihood of an accurate group decision increases with ... when a collective faces a variety of factors ... University researchers report that smaller groups actually tend to ... excessively focused on only certain pieces of information. , ... known about collective intelligence, or the "wisdom of crowds," ...
Breaking Biology News(10 mins):Study: Iron consumption can increase risk for heart disease 2Picky male black widow spiders prefer well-fed virgins 2Too many chefs: Smaller groups exhibit more accurate decision-making 2Too many chefs: Smaller groups exhibit more accurate decision-making 3
... Va. The availability of new genome sequencing ... to test an intriguing hypothesis about how agricultures ... plant pathogens. Boris Vinatzer, assistant professor of ... College of Agriculture and Life Sciences, has received ...
... GAINESVILLE, Fla. Using the genetic equivalent of an ... the Earth endured a massive cooling period between 500 ... (Feb. 7) in the journal Nature, researchers from the ... and the biotechnology company DNA2.0 describe how they reconstructed ...
... YORK (FEBRUARY 7, 2008) Madagascars turtles and tortoises, ... will continue to crawl steadily toward extinction unless major ... by the Wildlife Conservation Society and other groups. ... capital city Antananarivo, said there is still hope to ...
Cached Biology News:Tomato pathogen genome may offer clues about bacterial evolution at dawn of agriculture 2Scientists rebuild ancient proteins to reveal primordial Earth's temperature 2Madagascar's tortoises are crawling toward extinction, groups say 2
(Date:1/15/2014)... 2014 This webinar will focus on ... safety assessment in biosimilars. , Regulatory frameworks are evolving ... development, however the complex nature of biopharmaceuticals makes the ... efficacy extremely challenging. Based on the specific aspects of ...
(Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, ... is an emerging biomedical company acquiring, developing, manufacturing, and ... , Free report download: http://equitiesiq.com/reports/alliqua/ , In ... team and Board, which launched the company’s new strategy ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... and Brent Butler 2 , ... Massachusetts, USA , ... , Introduction , ... carried out using manual pipetting. As the demand for greater throughput of plate ...
... , , , , FLEXSTATION IS A ... SIMPLE, RAPID EXPERIMENTAL SET-UP AND DATA ANALYSIS , , ... , EXCELLENT FOR ASSAY DEVELOP-MENT AS DEMONSTRATED BY Z FACTOR ... G q -coupled receptors are transmembrane proteins that are responsible ...
... , HOMOGENEOUS ASSAY , , ... PROCEDURE , , COMPATIBLE WITH MORE TARGETS ... , The ... detecting changes,in intracellular calcium concentration.,Specifically, this fast and simple fluorescencebased,assay allows the ...
Cached Biology Technology:96 Well Pipetting Precision and Accuracy Using the RapidPlate 96/384 Workstation 296 Well Pipetting Precision and Accuracy Using the RapidPlate 96/384 Workstation 396 Well Pipetting Precision and Accuracy Using the RapidPlate 96/384 Workstation 4Gq-coupled receptor assays using FLEXstation: M1 muscarinic receptor 2Gq-coupled receptor assays using FLEXstation: M1 muscarinic receptor 3Gq-coupled receptor assays using FLEXstation: M1 muscarinic receptor 4Calcium Plus Assay Kit, Superior Detection for Specialized Targets 2Calcium Plus Assay Kit, Superior Detection for Specialized Targets 3
LECHNER AND LaVECK MEDIUMfor the clonal growth of normal human bronchial and other epithelial cells. Requires additives. With glutamine.Recommended storage condition:oC to 8oCIntended use(s):research...
...
... OrientExpress™ System Modules ... synthesis and directional cloning ... T7 expression vectors ... configuring OrientExpress™ Cloning Systems, ...
... and antibody-based immunoaffinity matrices, such as ... times without compromising antigen-antibody reactivity, the ... agents has precluded the application of ... The CHEMICON Re-Blot Plus Western Blot ...
Biology Products: