Navigation Links
New weapon in battle against osteoporosis

Medical researchers at the University of Bonn, working in collaboration with scientists from Israel, the USA and Britain, have identified a previously unknown regulatory mechanism in the process of bone loss. Their findings could open up new approaches to the treatment of osteoporosis. More than four million people, predominantly women, are estimated to suffer from this distressing illness in Germany alone. In recognition of the importance of her results, Dr. Meliha Karsak from the Bonn-based Life & Brain Center has recently been awarded the Osteology Prize of the German Society for Endocrinology, which entails a cash award of 8,000 euros. Her study will now be published in the renowned "Proceedings of the National Academy of Sciences" (PNAS).

Working together with colleagues from the University of Jeruslam, Dr. Meliha Karsak found that mice with a particular gene defect have a lower bone density. This breakthrough is making "cannabinoidreceptors" a key focus of osteoporosis research.

"We know two types of cannabinoidreceptors, CB1 and CB2," explains Dr. Karsak. "The CB1 receptor is formed by nerve cells in the brain and is responsible for, among other things, the mental effect of cannabis. The CB2 receptor, on the other hand, does not occur in nerve cells; its function was previously unknown." To explore this function the scientists working with Bonn's senior brain expert Professor Dr. Andreas Zimmer have made genetic modifications in mice in order to switch off their CB2 receptor. Dr. Karsak summarises what happened: "The animals gradually lost their stabilising trabeculae. We found in these mice that the number of osteoclasts ?special cells that can break down the bone tissue –increases by almost 50 per cent."

Signal molecules regulate bone density

Together with a research group from Israel and England, Dr. Karsak was able to demonstrate that osteoclasts, as well as their opposite number, the osteoblasts, which are respo
'"/>

Source:University of Bonn


Page: 1 2 3

Related biology news :

1. Could microbes solve Russias chemical weapons conundrum?
2. Venom doc tracks down snake bioweapons
3. Metal-containing compounds show promise as HIV weapon
4. The bioweapon is in the post
5. Scientists aim to thwart use of flu as bioweapon
6. Encoded metallic nanowires reveal bioweapons
7. Researchers find secret weapon used by SARS virus
8. Researchers identify new weapon to fight deadly bacterial sepsis
9. Global malaria map key weapon in fight against malaria, scientists say
10. New sensor detects gaseous chemical weapon surrogates in 45 seconds
11. Alien plants attack using resource conservation as weapon, researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New weapon battle against osteoporosis

(Date:9/21/2014)... United Nations General Assembly events focussed on ways to ... children, Grand Challenges Canada, funded by the Government of ... bold ideas to address this challenge. , The novel ... Bangladeshi mothers working in garment factories to express, pasteurize ... reducing absenteeism due to child illnesses, and lowering baby ...
(Date:9/21/2014)... autism are significantly less likely to report taking iron ... of children who are developing normally, a study by ... , Low iron intake was associated with a five-fold ... mother was 35 or older at the time of ... conditions such as obesity hypertension or diabetes. , The ...
(Date:9/21/2014)... September 22, 2014The story of cowpea (black-eyed peas) is ... world,s biggest problemseven more fascinating is the story of ... wrote Cowpea: The Food Legume of the 21st Century ... management, and use. The book was recently published by ... International Institute of Tropical Agriculture (IITA). , Singh has ...
Breaking Biology News(10 mins):Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 5Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 6Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 7Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 8Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 9Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 10Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 11Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 12Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 13Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 14Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 15Mothers of children with autism less likely to have taken iron supplements 2
... of phorid fly from Thailand is the smallest fly ever discovered. ... than a house fly and five times smaller than a fruit ... the first of its genus to be discovered in Asia, and ... "decapitating" ants. Some species in the Phoridae fly family lay ...
... open access journal Journal of Neuroinflammation suggests ... Alzheimer,s disease. To date it has been ... Alzheimer,s disease (AD), especially because trials of NSAIDs appeared ... Disease Anti-inflammatory Prevention Trial) trial was stopped early, recent ...
... leatherback turtles, the 21st century could be the last. ... threats and nearly wipe out the population. Deaths of ... drier beaches are the leading projected cause of the ... the journal Nature Climate Change by a ...
Cached Biology News:Rising heat at the beach threatens largest sea turtles, climate change models show 2Rising heat at the beach threatens largest sea turtles, climate change models show 3
(Date:9/22/2014)... METTLER TOLEDO is pleased to launch ... CNS110 ScanTape™ . Replacing a traditional tape ... ease and accuracy for transport and logistics personnel. ... productivity—an important benefit for load planning and revenue ... , Usable at any point in goods-transfer ...
(Date:9/22/2014)... , Sept. 22, 2014 Synageva ... ), a biopharmaceutical company developing therapeutic products for ... Robert Bazemore as Chief Operating Officer.  Reporting ... and Chief Executive Officer, Robert will oversee the ... program, sebelipase alfa for LAL Deficiency, and will ...
(Date:9/22/2014)... 2014  Spherix Incorporated (SPEX) -- an intellectual property development ... today announced that the United States Patent & Trademark Office ... month of September that is part of a standard essential ... USRE45,121 , Application number: US 13/728,867 , ... 27, 2012 The listed inventors of the ...
(Date:9/21/2014)... Researchers at the University of Basel in Switzerland ... of a charged molecule for the first time. ... precise measurements of molecular properties and may also ... quantum technology. The results were published in the ... the study of the interaction between matter and ...
Breaking Biology Technology:ScanTape™ Handheld Dimensioner Increases Processing Volume 2Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 2Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 3Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 4Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3Uncovering the forbidden side of molecules 2
... Oct. 9 /PRNewswire-FirstCall/ - Dr. Brad Thompson, President,and ... ONCY), will present a,corporate overview of the Company ... U.K. on Monday, October 13 at 2 p.m. ... II Conference Centre from October,12-14, 2008., About ...
... (eRT), (Nasdaq: ERES ), a leading provider ... services to the pharmaceutical,biotechnology, medical device, and related ... third quarter results for the period ended,September 30, ... market closes.,After the release, the Company will host ...
... support the achievement of several,value-creating, developments and ... Oct. 9 /PRNewswire-FirstCall/ - The Board of Directors ... today announced that the Company successfully completed as ... of convertible debentures,for gross proceeds of $2,750,000., ...
Cached Biology Technology:Media Advisory - Oncolytics Biotech Inc. to Present at BioPartnering Europe 2eResearchTechnology, Inc. to Announce 2008 Third Quarter Results on October 30, 2008 2Neptune Technologies successfully completes $2.75 million private placement with 10% management participation 2Neptune Technologies successfully completes $2.75 million private placement with 10% management participation 3Neptune Technologies successfully completes $2.75 million private placement with 10% management participation 4
... NeuroLog System is a compact, versatile & modular ... of purposes including: Intracellular, Extracellular, Transducer & ... The NeuroLog Case & Power Supply unit (NL900D) ... Modules are not only powered by this unit, ...
anti-Yan 8B12H9...
...
... T4 DNA Ligase catalyzes the formation ... ATP between double-stranded DNAs with 3' hydroxyl ... DNA Ligase buffer optimizes ligation which can ... nucleic acids are not substrates for this ...
Biology Products: