Navigation Links
New vaccine protects more effectively against tuberculosis

Max Planck researchers uncover the mechanism by which the new genetically engineered vaccine functionsThe vaccine has been licensed to the Vakzine Projekt Management who will test it in clinical trials early 2006. The responsible mechanisms for the high efficacy of this vaccine has now been deciphered (Journal of Clinical Investigations, August 18, 2005).

Globally, tuberculosis remains the number one killer in adults. Moreover, multi-drug-resistant tuberculosis strains are on the rise which cannot be treated by first-line drugs. A vaccine against tuberculosis, termed BCG is available which, however, fails to protect against the most frequent form of disease, pulmonary tuberculosis in adults. A more efficient vaccine is urgently needed for control of this global threat.

Recombinant BCG, which express listeriolysin and is deleted for the urease gene, has been created and shown to stimulate far more efficacious protection against tuberculosis than the BCG vaccine currently in use. This new vaccine induces cell death in infected host cells, which leads to stimulation of protection by dendritic cells, the most efficacious antigen-presenting cells. As a result, stronger protection against pulmonary tuberculosis has been achieved in preclinical studies. Importantly, the new vaccine also protects against clinical isolates of the Beijing family. These clinical isolates are frequently multi-drug-resistant and more aggressive and hence have started to conquer the globe. It has been assumed that the Beijing isolates emerged in response to drug treatment and vaccination. The new genetically engineered BCG could provide an efficacious measure against this threat.


'"/>

Source:Max-Planck-Gesellschaft


Page: 1

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New vaccine protects more effectively against tuberculosis

(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
(Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... In a study of adults aged 20 and ... acid are at much higher levels in individuals who have ... levels than in individuals who are also vitamin B12 deficient ... methylmalonic acid, compounds used by enzymes that contain vitamin B12, ...
... pass genes to the next generation. In sexually reproducing ... are vital for fertility. In a new study published ... at Cornell University knocked down the levels of 25 ... males abilities to modulate egg production, sperm storage and ...
... to remain through reporting of 2007 fiscal year, ... (Nasdaq:,AWRE), a leading supplier of broadband technology and ... the position of Chief,Financial Officer beginning in February ... 1996 until September 2003., Keith Farris, Aware,s ...
Cached Biology News:Vitamin B-12 function may be diminished by excessive folate 2Aware, Inc. Announces Richard Moberg to Return as CFO 2Aware, Inc. Announces Richard Moberg to Return as CFO 3
(Date:8/3/2015)... -- According to a new market report ... Asia to Witness Highest Growth by ... culture market was valued at US$ 586.1 Mn in 2014 ... 29.1% to account for US$ 2,717.6 Mn by 2020. ... 3D cell culture refers to a process ...
(Date:7/31/2015)... LAS VEGAS , July 31, 2015 /PRNewswire/ ... pharmacists seek resources that help them drive positive ... as a vital source of patient care in ... Pharmacy,s annual tradeshow and conference, AmerisourceBergen announced ... strengthen its Pharmacy Services Administration Organization and help ...
(Date:7/31/2015)... ... July 31, 2015 , ... R-Biopharm ... quantification of partially hydrolyzed gluten in foods, has been accepted by AOAC International ... “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” based on ...
(Date:7/30/2015)... Mass. , July 30, 2015   ... solutions for the interpretation and analysis of genomic ... Matthew Fischer has joined the company as ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... capabilities to integrate, interpret, analyze and explore complex ...
Breaking Biology Technology:Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2
... ... in a dynamic and unpredictable world at Wharton Leadership Conference. , ... Philadelphia, PA (Vocus) June 16, 2009 -- As the ... is well-positioned to deliver dynamic innovations to meet the evolving markets demand because “change is ...
... , PHILADELPHIA, June 16 The Pew Charitable Trusts ... Fellows in the Biomedical Sciences. The rigorously competitive program provides ... with leading researchers in the United States. Upon returning to ... equipment to continue their research in their home countries. ...
... SHANGHAI, June 16 /PRNewswire-Asia/ -- WuXi PharmaTech ... Edward Hu, the Company,s Chief Operating Officer and,acting Chief ... Conference in New York on Wednesday, June 17, 2009, ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , ...
Cached Biology Technology:Leading for Growth in the New Economic Reality Includes Vision and Innovation 2Leading for Growth in the New Economic Reality Includes Vision and Innovation 3Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences 2Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences 3