Navigation Links
New vaccine protects more effectively against tuberculosis

Max Planck researchers uncover the mechanism by which the new genetically engineered vaccine functionsThe vaccine has been licensed to the Vakzine Projekt Management who will test it in clinical trials early 2006. The responsible mechanisms for the high efficacy of this vaccine has now been deciphered (Journal of Clinical Investigations, August 18, 2005).

Globally, tuberculosis remains the number one killer in adults. Moreover, multi-drug-resistant tuberculosis strains are on the rise which cannot be treated by first-line drugs. A vaccine against tuberculosis, termed BCG is available which, however, fails to protect against the most frequent form of disease, pulmonary tuberculosis in adults. A more efficient vaccine is urgently needed for control of this global threat.

Recombinant BCG, which express listeriolysin and is deleted for the urease gene, has been created and shown to stimulate far more efficacious protection against tuberculosis than the BCG vaccine currently in use. This new vaccine induces cell death in infected host cells, which leads to stimulation of protection by dendritic cells, the most efficacious antigen-presenting cells. As a result, stronger protection against pulmonary tuberculosis has been achieved in preclinical studies. Importantly, the new vaccine also protects against clinical isolates of the Beijing family. These clinical isolates are frequently multi-drug-resistant and more aggressive and hence have started to conquer the globe. It has been assumed that the Beijing isolates emerged in response to drug treatment and vaccination. The new genetically engineered BCG could provide an efficacious measure against this threat.


'"/>

Source:Max-Planck-Gesellschaft


Page: 1

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New vaccine protects more effectively against tuberculosis

(Date:7/24/2014)... SAN DIEGO , July 24, 2014 /PRNewswire-iReach/ -- ... managing data from cardiac devices, has cut emergency room ... the UC San Diego (UCSD) Medical Center, according to ... Journal. The UCSD Emergency Departments are using the suite ... such as pacemakers or defibrillators. "Using Geneva,s ...
(Date:7/24/2014)... for food or commercial food sale, has been heavily ... of many species of primates and other mammals. ... of the species being consumed are birds, particularly large ... the meat made available for sale but the meat ... and brought to villages for consumption, we noted a ...
(Date:7/24/2014)... different effects on different species of fish, according ... Bristol and Exeter which tested fish anti-predator behaviour. ... flying seagull predator model when exposed to additional ... minnows. , Lead author Dr Irene Voellmy ... levels in many aquatic environments have increased substantially ...
Breaking Biology News(10 mins):UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... documents dating back 3,500 years say they have found ... ancient Egypt and not with Hippocrates and the Greeks. ... Biomedical Egyptology at The University of Manchester discovered the ... before Hippocrates was born. , "Classical scholars have ...
... and Gail Williams and Stockholm University's Professor Robin Room examined ... and 2002. , Their results were published in the ... Review. , The men were categorised according to ... is a marker for lower socio-economic status (SES). ...
... Investigator, and Nancy Bae, Ph.D., Postdoctoral Research Associate ... offering insight into the way cells protect chromosome ... tomorrow's issue of Molecular Cell, their paper entitled ... Human Telomeric DNA Ends" employed a biochemical assay ...
Cached Biology News:Egyptians, not Greeks were true fathers of medicine 2Double the death rate from cirrhosis for 'blue collar' men 2Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks 2
(Date:7/24/2014)... 24, 2014 SRI International has been awarded ... Institute of Allergy and Infectious Diseases (NIAID), part of ... of potential therapies for HIV infection and AIDS. The ... and AIDS and the complications and opportunistic infections associated ... sexual transmission of HIV. According to ...
(Date:7/24/2014)... Texas (PRWEB) July 24, 2014 ... Potassium Sulphate Industry” is a professional and in-depth ... report introduces Potassium Sulphate basic information, including ... and industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment & ...
(Date:7/24/2014)... July 24, 2014 1000 balances – ... input on customers’ weighing needs and expertly narrows down ... of balances, scales or even terminals. , First, ... smallest weight (or select readability instead) and define the ... additional selection criteria narrows down the list to models ...
(Date:7/24/2014)... , July 24, 2014  Spherix Incorporated (SPEX) -- ... and monetization of intellectual property, today announced that the ... ending June 30, 2014 on Monday, August 18, 2014 ... 10 a.m. ET on Monday, August 18, 2014 to ... by the company,s CEO, Anthony Hayes . ...
Breaking Biology Technology:National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Spherix Schedules Shareholder Update Call 2
... and biotech,companies are drawing on Singapore,s integrated network ... productivity, leverage academic,insights and diversify risks. Located at ... is representative of key Asian ethnic groups, Singapore ... and develop new solutions for,Asia and beyond. , ...
... an agreement-in-principle to ensure the valorization and the operation under ... Faculty of veterinary medicine in St-Hyacinthe, Quebec, Canada, for human ... ... Laval, Quebec (PRWEB) May 18, 2009 -- Universite de Montreal ...
... Simcere Pharmaceutical Group,("Simcere" or the "Company") (NYSE: SCR ... pharmaceuticals in China, today reported,unaudited financial results for the quarter ... -- Total revenue increased to RMB442.5 million ... first quarter of 2009 from RMB394.6 million for the corresponding, ...
Cached Biology Technology:Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 2Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 3Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 4Pharma and Biotech Companies Plug into Singapore's Integrated Research Network 5Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 2Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 3Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 4Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 5Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 6Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 7Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 8Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 9Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 10Simcere Pharmaceutical Group Reports Unaudited First Quarter 2009 Results 11
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Clone/PAD: ZMD.467. Immunogen: Synthetic ... of the human rat mouse dog ... Specific for the human occludin protein. ... cell lysates). Reactivity with rat ...
...
... Biochain's plant total protein ... for rapidly screening tissue specific ... Human placenta total protein is ... an interblot control for comparison ...
Biology Products: