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New vaccine prevents CMV infection and disease in mice

Neither approach alone would give complete protection.

“In mice, the vaccine not only fought the disease, but prevented the infection from being established in the first place,” Morello said.

Researchers at UCSD hope to begin pre-clinical work on development of a human vaccine. If successful, an FDA-approved, commercially licensed hCMV vaccine could be administered to specific at-risk populations, such as females prior to child-bearing years, day care providers, organ transplant recipients, or as part of regular childhood immunizations.

“This approach may also be valid for a number of diseases associated with persistent or latent infections, including all types of herpes-associated diseases, AIDS, or hepatitis,” said Spector. These viruses persist because immune responses generated by the viral infection are not able to eradicate the virus.
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Source:University of California - San Diego


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