Navigation Links
New vaccine prevents CMV infection and disease in mice

Researchers at the University of California, San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences have patented a strategy for developing a human vaccine to prevent against Human Cytomegalovirus (hCMV) infection and disease.

CMV, a type of herpes virus, is the leading viral cause of birth defects and a serious problem in patients with compromised immune systems. The body’s natural immunity doesn’t protect against infection by the virus, estimated to be present in 50 to 75 percent of all adults.

“Until now, scientists haven’t been able to develop a vaccine to protect against CMV,” said Deborah H. Spector, Ph.D., UCSD Professor of Cellular and Molecular Medicine and faculty member of the Skaggs School of Pharmacy and Pharmaceutical Sciences. “Using a two-pronged approach, we successfully created and tested a vaccine in a mouse model with CMV that shows enormous promise for re-directing the body’s immune system, enabling it to fight the virus.”

The mouse vaccine generates an immune response that protects against both infection and development of disease when the virus is present by completely disarming the virus’s ability to replicate and establish a persistent infection. The work is currently online in advance of publication in the July issue of Journal of Virology.

“Our approach generates an immune response that is different from the normal response to the virus, and we hope to have found an ‘Achilles’ heel’ in the defenses that the virus uses to evade the immune system,” said Spector. “The virus has evolved to persist in the host by evading the immune responses either by hiding or by misdirecting the host’s immune responses. We found a way to teach the host immune system to not be tricked by the virus.” She added that the next step is to apply this strategy to create a vaccine for use in humans.

CMV is a virus that, while carried by the majority of adults in the United States, can remain d
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New vaccine prevents CMV infection and disease mice

(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
(Date:11/21/2014)... Calif. , Nov. 20, 2014 Strict ... driver efficiency are piloting the North American and European ... of accidents growing, gesture recognition systems that are intuitive ... a mark in the industry. New ... Automotive Gesture Recognition Market in Europe ...
(Date:11/21/2014)... , Nov. 20, 2014   Atmel® Corporation ... in microcontroller (MCU) and touch technology solutions, today launched ... sensors with the widest V cc range ... temperature accuracy and faster I 2 C bus communication ... serial EEPROM memory making them ideal for consumer, industrial, ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... nearly 20 years, Frank Bayliss, mentoring work has made San ... students in the sciences. For his efforts, Bayliss has been ... Engineering Mentoring. Bayliss will officially receive the award during a ... had already been teaching biology at SF State for nearly ...
... rapidly to climate and habitat change and established a ... grounds, according to new research. An international research ... from the US, South Africa and Italy, led by ... Biomedical Sciences, Durham University, found that when the Antarctic ...
... Coastal marine ecosystems are at risk worldwide as a result ... who have recently published a study in the Journal ... integrated analysis of all coastal areas of the world. ... litany of impacts from human activities, from the land, such ...
Cached Biology News:SF State professor honored by President Obama for science mentoring 2Seals quickly respond to gain and loss of habitat under climate change 2Seals quickly respond to gain and loss of habitat under climate change 3New study ranks 'hotspots' of human impact on coastal areas 2
(Date:12/19/2014)... December 19, 2014 Bioject Medical ... and manufacturer of needle-free injection technology, today announced ... Immunomic Therapeutics, Inc. (“ITI”) for ITI to use ... its LAMP™ vaccine platform. , In the ... Worldwide license to the Biojector®-2000 that triggers based ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the ... Maroulis, Pharm.D. to the newly created position of Vice ... position, Dr. Maroulis will continue to manage the entire ... multi-site pharmacies as the company expands. Dr. Maroulis has ... he has served in many different capacities in the ...
(Date:12/19/2014)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today ... privately held company based in Redwood ... big data platform for centralized management and processing ... on-market Genomic Management Solution, Bina-GMS 1 , empowers ... and scalable analyses to maximize the value of ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources ... will grow at a 12 percent compound annual growth ... of the aging population and the increasing adoption of ... America will also spur demand for dental ... dental implant and periodontal treatments. Other key ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3
... Wis. The planned Wisconsin Institute for Discovery has ... Wisconsin-Madison: $50 million from John and Tashia Morgridge. , ,The ... Research Foundation, and the State Building Commission has approved $50 ... , ,John Morgridge, chairman of the board of Cisco Systems ...
... case anyone doubts that the Wisconsin Alumni Research Foundation has ... cell patent, Andy Cohn would like to disabuse them of ... said the foundation, armed with a $1.5 billion endowment, is ... stem cell patent. , ,In the wake of recent events, ...
... many companies have been downsizing their domain name portfolios ... had cooled. There has not been, however, a corresponding ... increase in the number of domain name cases filed ... name market has been reinvigorated due to the development ...
Cached Biology Technology:Morgridge gift enables phase one of Institute for Discovery 2WARF says it's ready for a legal challenge on stem cells 2WARF says it's ready for a legal challenge on stem cells 3WARF says it's ready for a legal challenge on stem cells 4Renew your domain name! 2Renew your domain name! 3Renew your domain name! 4
... is designed for stabilizing the coating ... for immunoassay development. It can ... coating and drying process and for ... also works as a blocking agent ...
... Tecans open platform for clinical diagnostic applications, ... performance in the clinical diagnostic and blood ... barcode reading and sample traceability as standard ... complies with the IVD-Directive* established in the ...
... of the smallest thermal cyclers on the market, ... the 0.5ml (20 samples) or 0.2ml microtube (25 ... heating and cooling rate of 3.6C/sec and 2.0C/sec ... Fast track programming with new quick dial ...
... new TC-412 thermal cycler, flexible on your protocols, ... a high performance, high sample throughput instrument at ... Flexible block format: The truly user-friendly fully ... in a matter of seconds without the need ...
Biology Products: