Navigation Links
New vaccine platform may fight infections with causes from influenza to bioterrorism

-kexin vaccine in three doses administered three weeks apart. Three weeks later, they were infected with pneumocystis. Upon examination, the vaccinated mice had significantly less organism in their lungs. According to the researchers, nearly 100 percent (999.999 percent) of the invading pneumocystis was thwarted by the vaccine-induced antibody-mediated process, compared to about 20 percent in animals that had not been vaccinated.

The number of people with compromised immune systems continues to rise, a population that cannot be protected against polio, the flu and other infectious agents with existing vaccines that depend on a normal T-cell response. As such, the researchers were motivated to develop CD4+ T-cell–independent therapeutic strategies to meet this growing need.

"While we'll need to replicate these findings in larger animal models, our studies indicate it may be feasible to develop vaccines for bioterrorism agents and transplant patients, as well as high-risk individuals who have defective CD4+ T-cell function," Dr. Kolls said. "We are excited about the results because they indicate that we can engineer a vaccine to create a new protection for those who are immunosuppressed."

In addition to Dr. Kolls, other authors include Mingquan Zheng, M.D.; Chad Steele, Ph.D., and Florencia McAllister, M.D., all of Children's Hospital and the department of pediatrics, University of Pittsburgh School of Medicine; Corrine Kliment, Christopher Crowe and Rekha R. Rapaka, University of Pittsburgh School of Medicine M.D.-Ph.D. students; Karen A. Norris, Ph.D., department of immunology, University of Pittsburgh School of Medicine; and Alistair J. Ramsey, Ph.D.; Myles B. Robichaux, M.S., Judd E. Shellito, M.D., and Paul Schwarzenberger, M.D., from Louisiana State University.


'"/>

Source:Children's Hospital of Pittsburgh


Page: 1 2 3

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
(Date:11/3/2014)... A University of Colorado Cancer Center study ... Academy of Sciences describes the activity of a ... Interleukin 37 or IL-37. It has been known to ... in the adaptive immune system: IL-37 inhibits the ability ... antigens. , "Knowing this mechanism that underlies IL-37,s effect ...
(Date:11/3/2014)... low birth weight and preterm birth are linked to ... Findings published in the American College of Rheumatology (ACR) ... low birth weight and pre-term babies were not at ... adults. , According to the ACR, 27 million ... clinical OA. Symptoms of OA range from mild to ...
(Date:11/2/2014)... ORLEANS, LA (2 November 2014)—In support of a bold ... Bill & Melinda Gates Foundation today announced an award ... Malaria Vaccine Initiative (MVI) in building new vaccines that ... help realize the "accelerating to zero" agenda. Such vaccines ... what could be called an "immunological bed net." ...
Breaking Biology News(10 mins):PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4
... waste from nearby manufacturing plants flowed into the waters ... The harbor, which is contaminated with polychlorinated biphenyls (PCBs) ... Superfund cleanup sites. It,s also the site of ... Institution (WHOI) and their colleagues have been working to ...
... The rapid conversion of natural lands to cement-dominated urban centers ... new study involving 147 cities worldwide, surprisingly high numbers of ... environments to the tune of hundreds of bird species ... Contrary to conventional wisdom that cities are a wasteland for ...
... bags, an abundant source of litter on land and ... and other useful petroleum products, researchers report. The ... results in transportation fuels diesel, for example ... biodiesels. Other products, such as natural gas, naphtha (a ...
Cached Biology News:Solving an evolutionary puzzle 2Solving an evolutionary puzzle 3Solving an evolutionary puzzle 4Cities support more native biodiversity than previously thought 2Cities support more native biodiversity than previously thought 3Plastic shopping bags make a fine diesel fuel, researchers report 2
(Date:11/21/2014)... , Todd Martensen ... Mariano Rodríguez es elegid vicepresidente senior de desarrollo empresarial ... en marcha para comenzar de forma rápida la comercialización de ... aprobación en Europa   , KLOX ... los siguientes nombramientos: Todd Martensen ha ...
(Date:11/21/2014)... Diego, CA (PRWEB) November 20, 2014 ... extended their Sartorius Entris Balance promotion . The ... customers seeking a durable, high accuracy, and easy-to-maintain balance ... made in Germany. It was designed to help customer’s ... affordable and a balance that is very durable. Sartorius ...
(Date:11/21/2014)... The report, "Synthetic Biology Market ... kits), Technology (Bioinformatics, Nanotechnology, Gene Synthesis, Cloning ... - Global Forecast to 2018", analyses and ... and challenges. , Browse 99 market data ... pages and in-depth TOC of the global ...
(Date:11/21/2014)... (PRWEB) November 21, 2014 Why did ... makes Albert Einstein so instantly recognizable? Why have they ... mathematician, astronomer and author Hilton Ratcliffe seeks out the ... nothing at all to do with science. In " ... Publishing , November 21, 2014), Ratcliffe puts it plainly: ...
Breaking Biology Technology:KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... Type III von Willebrand Disease, a serious, hereditary ... bleeding disorder, found in ... Behring today,announced that Iran,s Ministry of Health and Medical Education ... on an exclusive,basis throughout Iran, beginning immediately. Haemate P is ...
... Path for ... New Treatments, WILMINGTON, Del. and ... ) today announced,that they will collaborate to help advance understanding of Alzheimer,s,disease ... cutting-edge brain imaging methods., The new alliance will focus on the ...
... TUSTIN, Calif., Dec. 19 AMDL, Inc., (Amex:,ADL), ... a,developer, manufacturer, and marketer of pharmaceutical, nutraceutical,diagnostic, consumer ... open,its first large-scale JPGreen Health and Personal Care ... by Jade to be converted,into a flagship JPGreen ...
Cached Biology Technology:CSL Behring Expands Into Middle East Market with Haemate(R) P 2CSL Behring Expands Into Middle East Market with Haemate(R) P 3AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 2AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 3AstraZeneca and Banner Alzheimer's Institute Collaborate to Evaluate New Tool Targeting Alzheimer's Disease 4AMDL's First Full Service JPGreen Health and Personal Care Center Set to Open in Hangzhou, China 2
Rabbit polyclonal to SpUlp2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: SNNERQSLSSGSND, corresponding to amino acids 622-635 of Schizosaccharomyces pombe SpUlp2...
Lipid Phosphate Phosphohydrolase 2...
Request Info...
Chicken polyclonal to Thioredoxin domain containing 9 ( Abpromise for all tested applications). Antigen: Full length protein (Human) Entrez Gene ID: 10190 Swiss Protein ID: O14530...
Biology Products: