Navigation Links
New vaccine for condition that kills 500,000 children a year

fatal.

Efforts to eradicate rotavirus disease were almost derailed in 1999 when another vaccine was pulled from the market because it caused a rare bowel obstruction called intussusception at a rate of one in 10,000 patients. Intussusception takes place when the bowel folds in on itself, causing an intestinal blockage.

Because the bowel obstruction was so rare, and the increased incidence was so small, the only way to evaluate the safety of a new rotavirus vaccine was to launch a clinical trial involving more than 60,000 infants.

In 2000, Merck asked Matson to serve as the U.S. principal investigator in a clinical trial of RotaTeq, a vaccine under development.

RotaTeq targets five major strains of rotavirus, which account for 90 percent of rotavirus disease. The trial involved infants in the United States, Belgium, Costa Rica, Finland, Germany, Guatemala, Italy, Jamaica, Mexico, Sweden and Taiwan.

Infants were randomly assigned to receive three doses of vaccine or placebo, given four to 10 weeks apart. Because of the bowel obstruction associated with the withdrawn vaccine, a primary goal of the study was to determine whether RotaTeq was safe. Overall, 68,038 infants between six and 12 weeks participated, 34,035 in the vaccine group and 34,003 in the placebo group. All were monitored for serious adverse events, including intussusception.

During the study, infants who received the vaccine actually had a lower incidence of intussusception: 12 cases among vaccine recipients and 15 among those who received a placebo. No other significant side effects or complications were reported.

Rotateq also proved to be effective, nearly eliminating serious rotavirus-related gastroenteritis. The vaccine reduced rotavirus-related hospital admissions by 96 percent. In addition, RotaTeq reduced rotavirus-related emergency rooms visits by 94 percent, and doctor's office visits by 86 percent.

"The protective effect is stron
'"/>

Source:Eastern Virginia Medical School


Page: 1 2 3

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague

Post Your Comments:
(Date:11/30/2009)...rman . , The DFG has approved the establishm... 1 January 2010. This decision was made recently b...entres will initially be funded for four years wit...overhead funding for indirect costs will also be p...pics range from modern prostheses to political ref...
(Date:11/30/2009)...ts and engineers from two of the nation,s largest ...r Dec. 7 with leading academicians to explore the ...h like moving oil through a pipeline, the heart mu... clean, well-functioning pipes (or blood vessels),...iently. Both industries also are crucial to our na...
(Date:11/30/2009)...obal Conference on Systems & Enterprises (GCSE), t...ocuses on the convergence of complex large-scale s...ociety. , The goal of the conference is to b...ted complex systems, examined by domain, each succ...Infrastructure Systems, including Intelligent/Smar...
Breaking Biology News(10 mins):DFG approves funding for 17 new collaborative research centers 2DFG approves funding for 17 new collaborative research centers 3DFG approves funding for 17 new collaborative research centers 4DFG approves funding for 17 new collaborative research centers 5DFG approves funding for 17 new collaborative research centers 6DFG approves funding for 17 new collaborative research centers 7DFG approves funding for 17 new collaborative research centers 8DFG approves funding for 17 new collaborative research centers 9Similarities of pumping blood and oil examined 2Similarities of pumping blood and oil examined 3First global conference on systems and enterprises at new Stevens location, Washington, DC, Dec. 3-4 2GSA showcases groundbreaking aging research slated for Atlanta meeting 59757 1GSA showcases groundbreaking aging research slated for Atlanta meeting 59757 2GSA showcases groundbreaking aging research slated for Atlanta meeting 59757 3GSA showcases groundbreaking aging research slated for Atlanta meeting 59757 4Caltech scientists create robot surrogate for blind persons in testing visual prostheses 10414 1Caltech scientists create robot surrogate for blind persons in testing visual prostheses 10414 2Caltech scientists create robot surrogate for blind persons in testing visual prostheses 10414 3CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 1CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 2CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 3CDPHP Launches National Network and Three In One Plan and Expands Member Incentives 59754 4
...ieters or those who consume fewer calories during ...he flu virus, according to research by Michigan St...izabeth Gardner. , In a study published in the No...r showed that mice with a calorie-restricted diet ...of infection than mice with a normal diet. Caloric...
...e have shed light on some of the processes that re...that proteins are produced at the correct time, pl...ve shed light on the evolution of the DNA regions ...ry regions that, when bound to the protein GATA1, ...t role in the development of red blood cells. "Ou...
...tle worms live in intertidal surf, building sturdy... their own natural glue. University of Utah bioeng...rthy superglue, and hope it will be used within se...her joints and the face. , "You would glue some ...t, associate professor of bioengineering and senio...
Other Biology News:Feed a cold, feed a fever: Research shows calorie cut makes it harder to fight flu 2Scientists shed light on evolution of gene regulation 2Scientists shed light on evolution of gene regulation 3Superglue from the sea 2Superglue from the sea 3Superglue from the sea 4Superglue from the sea 5
(Date:11/27/2009)... A mechanised blue dye te...on to packaging quality assurance one step closer ...-contact leak testing machine developed by Seph...een installed in several local and global pharma-c...o address quality assurance and productivity impro...
(Date:11/25/2009)..., , BOSTON, Nov. 25 B... H1N1 virus, genomic data from the 1918 pandemic t...he current H1N1 pandemic, today issued its latest ...ows that the lethality of the H1N1 ("Swine Flu") v...uring the virus,s current outbreak in the spring o...
(Date:11/25/2009)..., , MARKHAM, ON, Nov. 25 /PRNewswire/ - Cyt...oldt, PhD to its Board of Directors. Dr. Moldt wil...tative on the Company,s Board. The number of Board...We are very pleased to welcome Peter Moldt to the ...rience and guidance as Cytochroma continues to mak...
(Date:11/25/2009)..., , SAN DIEGO, Nov. 25 /PRNewswire-FirstCa...nounced today that Barry D. Quart, Pharm.D., presi...the Piper Jaffray 21st Annual Health Care Conferen...r Jaffray 21st Annual Health Care Conference,Date:...m. Eastern Time,Location: The New York Palace Hot...
Breaking Biology Technology:Sepha's Blue Dye Test Alternative Brings ‘Complete Automation' To Pharma-Packaging Quality Assurance 2Sepha's Blue Dye Test Alternative Brings ‘Complete Automation' To Pharma-Packaging Quality Assurance 3Biological H1N1 Vaccines: Too Little, Too Late 2Biological H1N1 Vaccines: Too Little, Too Late 3Biological H1N1 Vaccines: Too Little, Too Late 4Biological H1N1 Vaccines: Too Little, Too Late 5Cytochroma Announces Appointment of Peter Moldt to Board of Directors 2Ardea Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference 2
... changed over the years is a funny thing. , ,When ...de ago, they were mostly talking about reaching ou...ities and business development leads. In other wor...meant "using your existing network". , ,Today, the...k about networking with people they already know, ...
...ve. The Milwaukee-area entrepreneur "bootstrapped"...l intelligence company, for three years before mov...has begun to thrive, it is well positioned to help... massive new demands that Medicare Part D, the new...thrust on their staffs, budgets and time. Part D b...
...dustry started in the late 1970s with the first IP...otech is already an industry more than 25 years ol...ng News ( GEN ) on March 1 states unequivocally t...they mature. If this is true, biotech is at the mi...ficance usually produces an industrial revolution,...
Other Biology Technology:Off-the-grid networking can help you cut past chit-chat 2Off-the-grid networking can help you cut past chit-chat 3Off-the-grid networking can help you cut past chit-chat 4Innovative Health Strategies near Milwaukee set to profit from Medicare expansion 2Innovative Health Strategies near Milwaukee set to profit from Medicare expansion 3Biotech industry reaches midpoint in 50-year maturation cycle 2Biotech industry reaches midpoint in 50-year maturation cycle 3Biotech industry reaches midpoint in 50-year maturation cycle 4Biotech industry reaches midpoint in 50-year maturation cycle 5
...in plasma from juvenile or male fish is a simple a...emicals (EDCs) with estrogenic effects in fish. Qu...ng test for the estrogenic effects of EDCs in fish...body immunometric (sandwich) EIA for analyzing Vtg...
...ic peptide whose sequence corresponds to residues ...e is (amino to carboxy terminus): V115 - L - P - ...- G - P - E133 (C) (The C-terminal cysteine has be...rt of the native rat SAP97 sequence.). This pept...
...ls were designed for full-length gene cloning and ...sired cDNA clone. The first PCR analysis is perfor...ontains plasmid DNA from 5,000 clones. Having iden... of the reaction products, the second PCR analysis...
...ls were designed for full-length gene cloning and ...sired cDNA clone. The first PCR analysis is perfor...ontains plasmid DNA from 5,000 clones. Having iden... of the reaction products, the second PCR analysis...
Biology Products: