Navigation Links
New understanding of cell movement may yield ways to brake cancer's spread

protein that binds to PIP3. PIP3 is a lipid that accumulates on the leading edge of a cell about to move, usually in response to a number of outside cellular attractants like chemokines, growth factors and other molecules. Meanwhile at the hind end of the cell, enzymes degrade the PIP3 lipid, creating a gradient from one end of the cell to the other.

It is this PIP3 lipid gradient that sets the cell into motion toward the right direction. The PIP3-binding portion of DOCK180 senses the gradient, and DOCK180 starts accumulating at the leading edge of the cell. Along with it, DOCK180 brings a host of additional molecules to the leading edge, triggering a series of internal events that begin moving the cell forward. "We see a protrusion form first, in which the cell changes shape and extends towards the direction it is about to go, followed by movement of the rest of the cell," Vuori said.

Now, the researchers are looking at developing a three-dimensional picture of PIP3 -binding domain's molecular structure. "We are currently planning these structure studies with our collaborators here at the Burnham," Vuori said. "If we know its molecular structure, we hope to be able to make small chemicals that inhibit inappropriate cell migration, including the types seen in metastatic cancer cells."


'"/>

Source:Burnham Institute


Page: 1 2

Related biology news :

1. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
2. Zebrafish may hold key to understanding human nerve cell development
3. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
4. Researchers make gains in understanding antibiotic resistance
5. Brain-mapping technique aids understanding of sleep, wakefulness
6. New understanding of DNA repair may pave way to cancer treatments
7. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
8. Virologists make major step towards understanding the process of HIV infection
9. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
10. New understanding of jet lag
11. NYU chemists use computer simulation to enhance understanding of DNA transcription
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New understanding cell movement may yield ways brake cancer spread

(Date:7/11/2014)... A new report from the Wildlife Conservation Society ... only help economically valuable species such as lobster, ... also help re-colonize nearby reef areas. , The ... a systematic review of research literature from no-take ... by Dr. Craig Dahlgren, a recognized expert in ...
(Date:7/11/2014)... Mills Canyon fire started near the City of Entiat ... local resources, the fire quickly grew to over 1,000 ... of the fire is under investigation by the Washington ... working with existing local resources in developing fire control ... Service (USFS), Washington State Department of Natural Resources, (WA ...
(Date:7/11/2014)... available in German . ... that uses the refraction of X-rays through a specimen ... with this method are often of much higher quality ... team of Prof. Franz Pfeiffer are particularly interested in ... including X-ray phase-contrast imaging. One main goal is ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2New simple setup for X-ray phase contrast 2
... the planet. They thrive in almost every known environment, ... that provide the capabilities essential for survival. These genetic ... mutation and exchange of genes and other bits of ... which then becomes an intrinsic part of the genome. ...
... URBANA - When University of Illinois researchers surveyed over 3,500 ... accurately, and overweight and obese men were more likely to ... because the first step in dealing with a weight problem ... U of I professor of food science and human nutrition. ...
... Most medical imaging equipment is not designed with overweight and ... be exposed to higher levels of radiation during routine X-ray ... Polytechnic Institute is the first to calculate exactly how much ... results show the internal organs of obese men receive 62 ...
Cached Biology News:Study shows unified process of evolution in bacteria and sexual eukaryotes 2Study shows unified process of evolution in bacteria and sexual eukaryotes 3Misperception of weight is an important barrier to weight loss 2Obese patients face higher radiation exposure from CT scans -- but new technology can help 2
(Date:7/10/2014)... , July 10, 2014 On ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique project ... project BIOCAD develops a number of innovative drugs based ... diseases. The ceremony took place at the International Exhibition ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... Adelaide research may help in the fight against terrorism ... tiny quantities of explosives with the use of light ... Sensors and Actuators B: Chemical , the researchers ... explosives in concentrations as low as 6.3 ppm (parts ... a few minutes. , "Traditionally explosives detection has involved ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2
... - NovaScan, an early-stage medical imaging company developing what ... of breast cancer, had to bypass angel tax credits from ... for its emerging technology. , ,The company instead has raised ... a state loan, and grants. , ,According to CEO Larry ...
... rural Wisconsin, one company is earning their bread and ... Networks, Inc. , a global satellite communications provider, has ... , a satellite-based broadband access provider. , ,IsoTropic operates ... set on 21 acres in rural Wisconsin, and it ...
... Last week, the nation marked the five-year anniversary of ... restrictions have unquestionably set back the progress of this ... Congress passed legislation that would have lifted President Bush's ... ones are suffering from a wide range of debilitating ...
Cached Biology Technology:NovaScan decides against tax credits 2Rural company works to improve broadband 2Stem cell research holds the promise for tomorrow 2Stem cell research holds the promise for tomorrow 3
... is the only PCR system that ensures ... time. It provides accuracy, consistency, and dependability ... the property of the DNA templates. This ... a unique blend of thermostable enzymes that ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
... to meet the needs of ... component-free medium supports fast cell ... densities, while maintaining high cell ... production using the Baculovirus Expression ...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
Biology Products: