Navigation Links
New understanding of DNA repair may pave way to cancer treatments

owth was primarily through its established function in the regulation of proteins important in cell cycle and cell death control. We were therefore most surprised to find an uncoupled function for the same protein," said Ronai.

The finding of ATF2's novel function in DNA repair was serendipitous. As Shoichi Takahashi, a postgraduate researcher, was testing for the changes in ATF2 in human cancers, he "lost the signal" for ATF2. "Later," Dr. Ronai said, "we did experiments that showed the signal was lost because a protein kinase, ATM, modified ATF2 enough to interfere with detection of the ATF2 signal. Soon, work performed by Anindita Bhoumik confirmed that ATF2 is regulated by ATM and that this regulation is central to the cell's ability to initiate DNA repair processes following ionizing irradiation or other exposures that cause breaks in DNA. A likely way in which ATF2 works is to halt the cell's cycle to allow repair of damaged DNA before such damage becomes permanent."

Ronai and his colleagues are now determining how molecules like ATF2 can balance their dual roles. "High doses of radiation, as well as changes that take place in cancer and pathologic situations, can activate both functions of ATF2, which is expected to disturb the otherwise conserved balance between its role in gene regulation and the DNA damage response. We need to find out which of the two functions is more dominant under these circumstances in order to devise ways to regain the proper balance," he said.

The Ronai lab's work on ATF2 was started at Mount Sinai School of Medicine in New York City, from which Dr Ronai and his colleagues recently relocated to the Burnham Institute. This study was carried out in collaboration with Wolfgang Breitweiser and Nic Jones of the Paterson Institute for Cancer Research, Manchester, England, and Yosef Shiloh, of Tel Aviv University, Israel. The study was supported by a grant from the National Institutes of Health.


'"/>

Source:Burnham Institute


Page: 1 2

Related biology news :

1. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
2. Zebrafish may hold key to understanding human nerve cell development
3. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
4. Researchers make gains in understanding antibiotic resistance
5. Brain-mapping technique aids understanding of sleep, wakefulness
6. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
7. Virologists make major step towards understanding the process of HIV infection
8. New understanding of cell movement may yield ways to brake cancers spread
9. Proteomics brings researchers closer to understanding microbes that produce acid mine drainage
10. New understanding of jet lag
11. NYU chemists use computer simulation to enhance understanding of DNA transcription
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New understanding DNA repair may pave way cancer treatments

(Date:9/21/2014)... the University of California, San Diego, have developed a ... control the activity of genes based on sequences of ... its application to human embryonic cells in a paper ... , "All of our cells have the same blueprint, ... John Whitaker, lead author of the report. "Skin cells ...
(Date:9/21/2014)... as mussels and barnacles secrete very sticky proteins that ... underwater. Inspired by these natural adhesives, a team of ... used to repair ships or help heal wounds and ... the MIT researchers engineered bacteria to produce a hybrid ... as a bacterial protein found in biofilms slimy ...
(Date:9/19/2014)... by researchers from several Harvard University labs in ... and aspiring researchers with the intellectual raw materials ... from soft, flexible materials. , With the advent ... advances in manufacturing technology, soft robotics is emerging ... from conventional rigid robot design, but working with ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3Soft robotics 'toolkit' features everything a robot-maker needs 2
... 12, 2009)The Society of Interventional Radiology hailed the ... in support of clinical patient management by vascular ... the critical contribution these minimally invasive specialists bring ... of ACR,s Resolution 22 is a continued endorsement ...
... This release is available in German . ... because of the limited amount of fossil fuels available, ... and other plant waste, are becoming the focus of ... the conversion of biomass into bio-oil, a highly promising ...
... Nlets Network and Hosting Services Enhances Law Enforcement ... Inc. (OTC Bulletin Board: BKYI), a leader in ... today announced a strategic partnership with Nlets. Nlets ... data communications network for the exchange of law ...
Cached Biology News:Interventional radiology: From sidelines to mainstream for patients 2Biomass as a source of raw materials 2BIO-key(R) Enters Strategic Partnership With Nlets 2BIO-key(R) Enters Strategic Partnership With Nlets 3
(Date:9/22/2014)... TORONTO , Sept. 22, 2014 ... announced that it has entered into a collaboration ... UHN,s Centre for Molecular Design and Preformulations (CMDP) ... The goal of the project is to increase ... proprietary buccal insulin spray product, thereby reducing the ...
(Date:9/22/2014)... 2014 METTLER TOLEDO is pleased ... measuring device CNS110 ScanTape™ . Replacing a ... offering greater ease and accuracy for transport and ... significantly enhance productivity—an important benefit for load planning ... equals profits. , Usable at any point ...
(Date:9/21/2014)... Chemical Sciences play a significant ... clean air and safe water, healthy food, and ... environmentalists, food scientists, educators, and scientists have a ... field of Chemistry for the national development, and ... of the fastest emerging Sciences, accelerating with a ...
(Date:9/19/2014)... is rarely simple. From crop yields to disease risks, ... those considered "complex traits." Just as for heightthe textbook ... particular human disease are shaped by multiple genetic and ... involved. To track down such genes, geneticists typically mate ... large mouse and a small mouseand then study their ...
Breaking Biology Technology:Generex Collaborates with University Health Network for Buccal Insulin Project 2Generex Collaborates with University Health Network for Buccal Insulin Project 3Generex Collaborates with University Health Network for Buccal Insulin Project 4ScanTape™ Handheld Dimensioner Increases Processing Volume 2Chemistry for Global Development during the Open Access Week 2Chemistry for Global Development during the Open Access Week 3Want to link genes to complex traits? Start with more diversity 2
... Company Selected to Participate in Gastroenterology Panel Discussion, ... ) announced today that Chief Executive Officer Elkan R. ... 2007 RBC Capital Markets Healthcare Conference taking place December ... Times Square in New York, New York.,The panel is ...
... Dec. 10 Lexicon,Pharmaceuticals, Inc. (Nasdaq: LXRX ) ... participate in the RBC Capital Markets,Healthcare Conference panel Going ... Westin Times Square Hotel in New York, New York ... A live audio webcast of the panel presentation ...
... Harrisburg Regional Education Consortium Promoting Advanced Technology,Industries ... High school and,college students from the Harrisburg ... and curriculum through a special collaboration,between several ... BioTech Day 2007, hosted by the Harrisburg ...
Cached Biology Technology:Pharmos Corporation to Present at the 2007 RBC Capital Markets Healthcare Conference 2Lexicon Pharmaceuticals to Present at RBC Capital Markets Healthcare Conference 2Capital Area Biotechnology Partnership Receives $160,000 State Investment 2
... dispenser combining the most versatile features for bulk ... existing Multidrop dispensers. , ,It is designed ... nl up to 2500 l with excellent precision ... for multiple plate formats (96, 384, 1536) including ...
... Multidrop Combi is a new generation bulk ... flexibility and simplicity for pharmaceutical and biotech ... reliable Multidrop range, Multidrop Combi has been ... volumes of 0.5-2500 l and multiple plate ...
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Biology Products: