Navigation Links
New type of rejection blocker protects kidneys after transplant

In an international clinical trial, a new drug that selectively blocks immune responses has proved as effective in preventing acute kidney transplant rejection as cyclosporine, the standard anti-rejection treatment.

Patients who took the experimental drug, a co-stimulatory blocker called belatacept (LEA29Y), also had better kidney function and experienced less of the toxic side effects associated with standard anti-rejection drugs, including kidney damage, high blood pressure and high cholesterol.

In the August 25 issue of The New England Journal of Medicine, researchers report on the safety and efficacy of belatacept during a randomized phase II clinical study of 218 patients, conducted at 22 centers in the United States, Canada and seven European countries. Flavio Vincenti, MD, of the University of California, San Francisco, and Christian Larsen, MD, of Emory University in Atlanta, were co-principal authors of the study.

The results mark an important step toward proving the value of a new type of treatment based on blocking the immune system's reaction to a transplanted organ without hampering the body's ability to fight diseases and infections, according to Vincenti, clinical professor of medicine and surgery at UCSF and a kidney transplant specialist at UCSF Medical Center.

"This is the first clinical trial of a treatment for transplant recipients based on this new principle of inducing immune tolerance of the transplanted organ. If belatacept and similar drugs live up to their promise, they will usher in a new paradigm for organ transplantation," Vincenti said. Instead of sending patients home with a collection of medications that must be taken daily to prevent rejection by suppressing the immune system's hostile response to a transplanted organ, Vincenti said he expects his patients to receive an injected immune tolerance treatment a few times a year -- and perhaps to be able to stop taking anti-rejection drugs altogether.


'"/>

Source:University of California - San Francisco


Page: 1 2 3 4

Related biology news :

1. Simple sea sponge helps scientists understand tissue rejection
2. Researchers identify genes associated with lung transplant rejection
3. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
4. Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
5. Proteins may predict lung transplant rejection
6. Survival of heart patients on beta-blockers varies greatly with genetic variation
7. Bound for destruction: Ubiquitination protects against improper Notch signaling
8. Experiments provide proof of how traveling in groups protects insects
9. Experiments provide proof of how traveling in groups protects insects
10. Substance protects resilient staph bacteria
11. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New type rejection blocker protects kidneys after transplant

(Date:10/15/2014)... admitted Johannes Gutenberg University Mainz (JGU) as a ... continues to maintain a significant nationwide standing in ... acceptance of Johannes Gutenberg University Mainz as a ... in the national and international competition for the ... Rhineland-Palatinate can be proud that Mainz University has ...
(Date:10/15/2014)... Lithuania , Oct. 15, 2014   ... technologies, today announced the availability of the ... VeriLook Surveillance 3.0 provides real-time biometric face identification ... high-resolution digital surveillance cameras. The new version not ... and differentiates people from objects while they are ...
(Date:10/14/2014)... One of the planet,s leading questions is how to ... increasingly variable climate. The Food and Agriculture Organization of ... 70% over the next 40 years to feed a ... of the necessary rise in food production. Plants—grains, ... by supporting livestock. Current research must tap into ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... modified mice and rats in combination with an animal model ... researchers new insight in the development of kidney disease. ... International. , "Chronic kidney disease is difficult to study since ... Joost P. Schanstra, Ph.D. of the Instituit Louis Bugnard inFrance. ...
... the effects of climate change on rainforests is being ... the shape of epiphytes ('air-plants' which grow on other ... evaporation have been affected by climate change over the ... as bromeliads, Monica Mejia-Chang from Professor Howard Griffiths' lab ...
... for its therapeutic effect on burned or irritated skin, but ... a healthful additive to your fruits and veggies. Researchers in ... plant that can be used as an edible coating to ... which does not appear to affect food taste or appearance, ...
Cached Biology News:Aloe vera coating may prolong freshness, safety of fruits and vegetables 2
(Date:10/19/2014)... (PRWEB) October 20, 2014 ... Industry Meeting (ABIM). ABIM will take ... More information about ABIM 2014 is now ... , Delegates representing companies and organizations from ... and obtain information on the latest products ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asia-Pacific ... Analytics market in Asia-Pacific with analysis and forecast of ... million in 2014 to $208 million by 2019, at ... 2014 to 2019. , Browse through the TOC of ... idea of the in-depth analysis provided. It also provides ...
(Date:10/19/2014)... 19, 2014 According to market ... Points; WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts ... the global Outdoor Wi-Fi market with analysis and ... MarketsandMarkets also identifies the drivers and the restrains ... trends, opportunities and challenges. , Browse 65 market ...
(Date:10/18/2014)... Asian arthroscopic devices report defines and segments the concerned ... The arthroscopic devices market in Asia is estimated to ... of 6.5% from 2013 to 2018. , Browse through ... get an idea of the in-depth analysis provided. This ... devices market in the same region, and is supported ...
Breaking Biology Technology:The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4
... durable responses in Phase I/II ... ... Medicine, LLC (SM),a wholly-owned subsidiary of Cell Therapeutics, Inc. (CTI) (Nasdaq: ... cisplatin with brostallicin in patients with solid tumors that,had relapsed or ...
... Syngenta and the Royal,Society of Chemistry today announced the ... the economic and social development of,the continent. The Network, ... initially in Kenya. Its purpose is to connect African,chemists ... levels of,innovation and scientific development., Syngenta is supporting ...
... be published Nov. 22 in the online edition of ... researchers reports the genetic reprogramming of human skin cells ... finding is not only a critical scientific accomplishment, but ... stem cell biology as human embryos may no longer ...
Cached Biology Technology:Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers 2Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers 3Syngenta and The Royal Society of Chemistry Launch African Science Initiative 2Syngenta and The Royal Society of Chemistry Launch African Science Initiative 3UW-Madison scientists guide human skin cells to embryonic state 2UW-Madison scientists guide human skin cells to embryonic state 3
... consists of FAST RED chromogen,tablets and substrate ... of alkaline phosphatase to produce red staining ... RED System provides enough material for 300 ... Vial A: 6 Tablets , Vial B: ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
... effectively in tubes and 96 well plates. microCLEAN ... one and a half spin DNA cleanup reagent. ... concentrate any type of double stranded DNA, efficiently ... dNTPs (labelled or unlabelled). It is therefore ideally ...
... cycler holds 96 x 0.2 ml tubes ... lid incorporates a thumbwheel to adjust height ... for oil-free cycling. Peltier heat pumps produce ... ramping rates of up to 1.4 degrees ...
Biology Products: