Navigation Links
New tumor-suppressor gene discovered

hniques, we were able to introduce a normal mats gene into the chromosomes of flies whose mats gene was mutated," Lai explains. "We found that the line of flies with this additional normal mats gene no longer developed tumors.

The researchers also inserted a human mats gene into the line of mats-mutant flies and found that the human gene is able to perform the same function as the fly gene. Additional experiments also revealed that the mats gene is required for normal differentiation of eye cells during the development of the fly's eye.

Lai's team also tackled the tough challenge of discovering how the mats gene is able to suppress the growth of tumors. "We did not find many clues when we compared the sequence of the mats gene with the sequence of other genes in the public databases," Lai says. "But we did find a counterpart to the mats gene in yeast. This yeast counterpart is known to make a protein that forms a complex with a kinase--an enzyme that catalyzes genetic activity--so we wondered if the protein product of our mats gene also could function in this way." Lai was particularly intrigued by the possibility that the protein product of the mats gene could partner with the kinase product of a known tumor-suppressor gene named "wts," which turned out to be the case.

The researchers performed three experiments to test whether the mats and wts genes interact genetically. In the first experiment, they inserted an additional normal mats gene into a line of flies and found no change in the shape of the flys' eyes. In the second experiment, they inserted an additional normal wts gene and found that the fly's eyes were decreased in size and deformed. In the third experiment, they inserted both a mats gene and a wts gene. "We found that mats and wts together can shrink the fly's eye much more dramatically," Lai reports. "Their effect is not additive, but synergistic. The two genes have a more powerful effect when they combine to work together in
'"/>

Source:Penn State


Page: 1 2 3 4

Related biology news :

1. Function of new cancer genes discovered
2. Novel mechanism for DNA replication discovered
3. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
4. Small molecule inhibitor of cholera discovered
5. Source of crucial immune cell in the skin discovered
6. Parkinsons disease mechanism discovered
7. Stomach receptor for H. pylori discovered
8. Emotional control circuit of brains fear response discovered
9. New dopamine brain target discovered
10. New hereditary breast cancer gene discovered
11. New mechanism for nutrient uptake discovered
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New tumor suppressor gene discovered

(Date:4/23/2014)... source of a unique rhythmic sound, recorded for decades ... the Antarctic minke whale ( Balaenoptera bonaerensis ). First ... who thought it sounded like a duck, the bio-duck ... Southern Ocean, but its source has remained a mystery, ... of researchers deployed acoustic tags on two Antarctic minke ...
(Date:4/23/2014)... gas boom has transformed the energy landscape in ... could cause conflict among the energy industry, residents ... researchers. They add that degraded water quality is ... The feature article appears in the ACS journal ... S. Mauter and colleagues point out that a ...
(Date:4/23/2014)... Heidelberg, 23 April 2013 EMBO today announced Sophie ... winner of the 2014 EMBO Gold Medal. The award ... define the organization and development of the cell. , ... to understand cellular polarity, in particular the way in ... size and cell division. In the last 11 years, ...
Breaking Biology News(10 mins):Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3How to avoid water wars between 'fracking' industry and residents 2EMBO Gold Medal 2014 awarded to Sophie Martin 2
... , , , , ... AUDIO: Falon Tilley and Michael W. Beets discuss the successful implementation of ... Click here for more information. , , ... , , , , , ...
... by Jonathan Waxman is a collection of short stories that ... a doctor,s life before the dawn of management. Written in ... from the author,s decades of clinical experience. Chutney Wars, The ... a few of the chapters in this engagingly written book. ...
... have been awarded fellowships from the Alfred P. ... NYU,s Center for Neural Science, and Nicholas Stavropoulos, ... NYU Langone Medical Center and its Neuroscience Institute. ... and scholars "whose achievements and potential identify them ...
Cached Biology News:Healthy Lunchbox Challenge helps influence healthy eating habits in children 2Healthy Lunchbox Challenge helps influence healthy eating habits in children 3Healthy Lunchbox Challenge helps influence healthy eating habits in children 4Two NYU faculty win Sloan Foundation research fellowships 2
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... conjugates for cancer, today announced the appointment of Thomas C ... has over 20 years, development experience gained in the biotechnology ... "I am delighted to welcome Tom at this ...
(Date:1/15/2014)... Houston, TX (PRWEB) January 15, 2014 ... Alzheimer’s disease, and about 1 in 3 seniors will ... ( source ). These jaw-dropping figures have shocked many ... function and, hopefully, help prevent these tragic age-related cognitive ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... / Electroporator 2510 , , , , , , , ... Protocol No. 4308 915.521 02/2002 , , , , ... , Microorganism , Mycobacterium intracellulare ... type , Bacteria, gram positive, , ...
... , , , , , , , ... Protocol No. 4308 915.046 11/2001 , , , , , ... , Cell line , L2, Schneider cells, Drosophila, ... pActin-SV-EGFP, , , ...
... , , , , , , Multiporator , , ... , Transfection Protocol , Protocol No. ... , , , , , ... cells (suspension cell line), , , ...
Cached Biology Technology:Mycobacterium intracellulare 2L2 2HL-60 2
For the quantitative determination of canine Interleukin 10,(IL-10) concentrations in cell culture supernates, canine serum,and plasma....
RAT ANTI RAT RT1Au (CLASS I POLYMORPHIC) Immunogen: AO lymphoid cells...
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
Biology Products: