Navigation Links
New tumor-suppressor gene discovered

es, which developed tumors on their bodies. Lai suspected that these flies had a naturally occurring genetic defect that caused them to develop the tumors. He used genetic-mapping techniques to study the mutant fly's chromosomes and identified a short segment of DNA on which a mutant gene was most likely to occur. "Genetic techniques helped us to narrow our search for this fly's mutation to a few candidate genes within a very small part of one huge chromosome," Lai explains. The scientists narrowed the tumor-causing candidates down to two genes, then performed molecular-biology experiments with them both, revealing that the defective gene is the one they now call mats.

Lai's lab discovered that the mats gene had a mutation--an additional piece of DNA that had somehow become inserted into the molecular sequence of the gene. This mutation was a type of "transposable element" known to be able to jump to different locations along the DNA. The inserted material disrupted the gene's function, which is to make a particular protein that works in particular ways. "A mutant gene is not going to make the protein product that the normal gene is able to make," Lai explains.

Lai then generated mutant clones of this fly and found that they developed large tumors in many organs including the head, eye, wing, leg, and antenna. He also generated another mutant form of the mats gene--this time with a huge missing pie ce of genetic material caused by another transposable element jumping out and dragging lots of material along with it. "With such a deletion of material, this gene is basically gone, so we knew it couldn't possibly function at all," Lai says. Both kinds of mutations resulted in the formation of the same kinds of tumors. These studies indicate that the disabling of this one gene alone can cause the growth of tumors.

The researchers then did a number of experiments to study this line of flies with the clearly defective mats gene. "With transgenic tec
'"/>

Source:Penn State


Page: 1 2 3 4

Related biology news :

1. Function of new cancer genes discovered
2. Novel mechanism for DNA replication discovered
3. Mechanism for Epstein-Barr virus proteins role in blood cancers discovered
4. Small molecule inhibitor of cholera discovered
5. Source of crucial immune cell in the skin discovered
6. Parkinsons disease mechanism discovered
7. Stomach receptor for H. pylori discovered
8. Emotional control circuit of brains fear response discovered
9. New dopamine brain target discovered
10. New hereditary breast cancer gene discovered
11. New mechanism for nutrient uptake discovered
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New tumor suppressor gene discovered

(Date:6/25/2015)... According to a new ... Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive & ... Others) & Geography - Global Forecast to 2014 ... is expected to reach $14,500.07 Million by 2020, ... Browse 76 market Tables and 109 Figures spread ...
(Date:6/24/2015)... 24, 2015 The biologics safety testing market ... for the market include growth of the pharmaceutical and ... launches. Over the years, the number of drug approvals ... 2010, the FDA approved 225 drug applications and Health ... Europe accounted for 3,822 of the ...
(Date:6/24/2015)... DUBLIN , June 22, 2015 ... has announced the addition of the "Huawei ... Analysis" report to their offering. ... going to the opposite direction than Apple,s and ... innovative fingerprint sensor developed by Fingerprint Cards, a ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... and Research Center report in the March issue of ... as fibulins 3 and 5, slow the growth of ... sprouting. The proteins are promising candidates for use in ... which regulate cell proliferation, migration and invasion. In the ...
... imaging study shows that age-related breakdown of myelin, the ... with the presence of a key genetic risk factor ... the January edition of the peer-reviewed journal Archives of ... evidence that myelin breakdown is a key contributor to ...
... home, but the presence of gas stresses out plants too. ... University of Nottingham have found that changes in the physical ... leaks in natural gas pipelines. "Our study was about ... leaks via the spectrum of reflected light from plants, which ...
Cached Biology News:Proteins stop blood-vessel and tumor growth in mice 2Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown 2Plants used to detect gas leaks, from outer space! 2
(Date:7/30/2015)... , July 30, 2015   GenoSpace ... for the interpretation and analysis of genomic and ... Fischer has joined the company as Vice ... - http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace ... to integrate, interpret, analyze and explore complex sets ...
(Date:7/30/2015)... CITY, Kan. , July 30, 2015 /PRNewswire/ ... ), a pet therapeutics company focused on the ... for companion animals, today announced that its strategic ... from a dose confirmation study of AT-016, an ... Aratana for the treatment of osteoarthritis pain in ...
(Date:7/30/2015)... July 30, 2015  Discovery Laboratories, Inc. (Nasdaq: ... received the second $1.0M tranche under a previously ... grant valued at up to $3.0 million to ... surfactant as a potential medical countermeasure to mitigate ... was awarded an initial $1.0 million under this ...
(Date:7/29/2015)... 30, 2015 According to a new ... Trends & Forecasts (2015-2020), , published by Mordor Intelligence, the ... by the end of 2020, with North America ... than 40% of the global market size. The Global market ... of 13.7% during the period of (2015-2020).      ...
Breaking Biology Technology:GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3
... week from his position as director of the nonpartisan ... on the reasons for his ouster. , ,And while ... results of an audit of the bureaus performance as ... Speaker John Gard (R-Peshtigo) said the move was simple ...
... WI. - A business Internet Service Provider (ISP) in ... getting ready to launch a virus protection service ... FirstBridge, McAfee and Postini. , , Cyberlynk Network Inc. ... to add virus protection to the service offering in ...
... , ,MADISON-WI. - The Wisconsin Technology Network recently ... researcher about his work in games and education, and ... used in academics. , ,Kurt Squire, Ph.D., was ... his research on games and learning. A former elementary ...
Cached Biology Technology:Wahl Mute on Firing from Legislative IT Bureau -- but politics could be to blame 2Franklin Firm to Pick Fight with Postini? 2Franklin Firm to Pick Fight with Postini? 3Franklin Firm to Pick Fight with Postini? 4GameBased Learning Strategies 2GameBased Learning Strategies 3
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
... Rabbit polyclonal antibody to human XAB2 (amino ... first identified through its interaction with XPA. ... fraction of XAB2 interacts with the transcription-coupled ... as with RNA polymerase II. Microinjection experiments ...
... coating using advanced automated high throughput microplate processing equipment that ... also accommodate virtually any lot size of the following formats ... 8 and 12 well strips, ... 384 well microplate, ...
...
Biology Products: