Navigation Links
New tool reveals secrets of migrating cells

suggest that this exploration probably is a search for a signal that will decide the cell's fate. In their experiments on one lobe of the mouse thymus, in fact, Witt and her colleagues saw cells, possibly those that have made a decision on their fate, halt their wanderings and make a beeline out of the cortex to the medulla, something immature T cells can't do.

The scenario they've reconstructed from the video and mathematical analysis starts with immature T cells moving out of the center of the thymus, the medulla, to the very outside edge of the cortex, where they proliferate and fill up the cortex. At this point, Witt said, they undergo the first of two tests to see if their surface receptors (called T cell receptors) work properly.

Once they pass that test, they start wandering around in the cortex looking for the second test, which is to bind precisely to a protein called the major histocompatibility complex (MHC). These cells, the researchers think, are the meanderers. Only about one percent of thymocytes pass both tests, but Witt and Robey think that those that do are the ones they see beelining out of the cortex into the medulla to begin their two-week education to distinguish "self" from "non-self" invader.

"To pass into the medulla they have to pass a screening test called positive selection," Witt said. "Once they do, the cells move very directly at a very fast speed inward toward the medulla, adopting a polarized shape characteristic of migrating cells."

While Witt and Robey continue their two-photon imaging studies of thymus cells and lymph cells, Witt is trying to encourage the technology's use in biology generally.

"Immunology is just one example of a subdiscipline of biology that stands to benefit enormously from our new ability to see in four-dimensions - in 3-D in real time. It opens an entirely different universe to us," Witt said.

Images and videos :



Source:University of California - Berkeley


Page: 1 2 3 4 5

Related biology news :

1. A bacterial genome reveals new targets to combat infectious disease
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
4. NYU study reveals how brains immune system fights viral encephalitis
5. Study reveals new technique for fingerprinting environmental samples
6. Study reveals dramatic difference between breast cancers in US and Africa
7. UCSD research reveals mechanism involved with type of fatal epilepsy
8. Study reveals candidate targets for anti-retroviral therapeutics
9. Chimp genome reveals a retroviral invasion
10. Survey reveals women and doctors arent talking about HPV
11. Bioinformatics reveals new gene regulation system
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New tool reveals secrets migrating cells

(Date:7/28/2014)... Roald Amundsen became the first man to reach the ... years later, an international team of scientists led by ... proven that air pollution from industrial activities arrived long ... from widely spaced locations around the Antarctic continent, including ... and precise reconstruction to date of lead pollution over ...
(Date:7/27/2014)... in vitro study has revealed that nicotine and cotinine, ... caused by a certain carcinogen in smoke. , The ... of tobacco leaves and ultimately ends up in the ... lung and liver, where it is activated by a ... in mice has revealed that nicotine can partially interfere ...
(Date:7/27/2014)... that wiped them out if it had taken place ... A fresh study using up-to-date fossil records and improved ... narrative of the prehistoric creatures, demise, some 66 million ... million years before a 10km-wide asteroid struck what is ... extensive volcanic activity, changing sea levels and varying temperatures. ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3Nicotine found to inhibit DNA-strand break caused by a certain carcinogen in smoke 2Dinosaurs fell victim to perfect storm of events, study shows 2
... to make proteins, key building blocks of all organisms, ... instructions for assembling them. An Iowa State ... marking where these instructions are located in a cell,s ... Journal of Biological Chemistry , Michael Shogren-Knaak, assistant professor ...
... Service scientists have completed a study on a beetle that ... attacked 67 percent of the oak trees in an area ... in the current issue of The Pan-Pacific Entomologist ... so rare it does not even have an accepted common ...
... of Eve to the venomous murder of the mighty Thor, ... of mischief and misery. The worldwide prominence of ... to the serpentbut why, when so few of us have ... Davis, anthropology professor Lynne A. Isbell suggests, lies in the ...
Cached Biology News:New Southern California beetle killing oaks 2
(Date:7/24/2014)... -- A novel combination of microscopy and data processing ... Ridge National Laboratory an unprecedented look at the surface ... electrochemical properties. , The research team led by ... of a perovskite manganite, a complex material that exhibits ... understand surface behavior could benefit researchers who are interested ...
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... by group leader Yung-Eun Sung has announced that ... and nitrogen-doped graphenes which can be applied as ... cells. Yung-Eun Sung is both a group leader ... for Basic Science* (IBS) and a professor at ... great significance with regards to the development of ...
(Date:7/24/2014)... most natural and synthetic processes prefer to settle ... or energyit is within the realm of non-equilibrium ... constant changes in energy and phases, such as ... conditions allow humans to regulate their body temperature, ... with seismic activity. , But even though ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4New approach to form non-equilibrium structures 2
... , , , , , ... in eukaryotic cell cultures , requires double-stranded molecules known ... licensed supplier of siRNA, offering a custom , ... directed against common target genes, and a Cancer , ...
... For transfection of eukaryotic cells with RNA and siRNA , , , , , , ... Kit Contents , Storage and Stability ... Technical Assistance , Product Use Limitations ... Safety Information , ...
... QIAshredder spin columns are designed for simple and rapid homogenization , of cell and tissue lysates. ... , , Format: , ... , , Sample source: , ... plant cell or tissue lysates, white blood cell lysates, , ...
Cached Biology Technology:RNAi Gene Silencing System 2RNAi Gene Silencing System 3TransMessenger Transfection Reagent Handbook 2TransMessenger Transfection Reagent Handbook 3TransMessenger Transfection Reagent Handbook 4TransMessenger Transfection Reagent Handbook 5TransMessenger Transfection Reagent Handbook 6TransMessenger Transfection Reagent Handbook 7TransMessenger Transfection Reagent Handbook 8TransMessenger Transfection Reagent Handbook 9TransMessenger Transfection Reagent Handbook 10TransMessenger Transfection Reagent Handbook 11TransMessenger Transfection Reagent Handbook 12TransMessenger Transfection Reagent Handbook 13TransMessenger Transfection Reagent Handbook 14TransMessenger Transfection Reagent Handbook 15TransMessenger Transfection Reagent Handbook 16TransMessenger Transfection Reagent Handbook 17TransMessenger Transfection Reagent Handbook 18TransMessenger Transfection Reagent Handbook 19TransMessenger Transfection Reagent Handbook 20TransMessenger Transfection Reagent Handbook 21TransMessenger Transfection Reagent Handbook 22TransMessenger Transfection Reagent Handbook 23TransMessenger Transfection Reagent Handbook 24TransMessenger Transfection Reagent Handbook 25QIAshredder Homogenizer 2
Viral CMV UL146/vCXC1 Biotinylated Affinity Purified PAb...
Cyan Standard is 7-hydroxy-4-trifluoromethylcoumarin...
... small volume applications, including pediatric, neonatal, geriatric, general adult, veterinary and experimental animals. Automatic Calibration with ... ... ... ...
X-Gal, 100 mg. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzy...
Biology Products: