Navigation Links
New tool reveals secrets of migrating cells

migrations have been inferred from observations of chemically fixed tissue at different stages of development.

"Two-photon imaging is going to change literally forever the way that we do biological science," said Witt, a developmental immunologist. "In the past, we'd take organs out, smush them up and basically do biochemistry in test tubes, or watch their behavior in a single layer of cells. It's an imaging revolution to be able to go into the native environment while keeping the intact organ alive and make movies of migrating cells."

With two-photon imaging, Witt and Robey identified thymus cells they dubbed beeliners moving nearly two centimeters - almost an inch - per hour, which is fast in the realm of cell movement. They think that these are cells that have received a signal committing them to be either a helper T cell - which aids other immune cells in fighting infections - or a killer T cell that seeks and destroys cells infected with virus.

On the other hand, uncommitted or immature T cells, what they call meanderers, wander slowly and apparently randomly around the outer layer, or cortex, of the thymus, perhaps in search of that life-altering signal.

Robey hopes to use two-photon imaging to investigate the signals responsible for changing these meanderers into purposeful beeliners that immediately leave the cortex for the interior medulla of the thymus.

"We're now at the point with this technology that we can begin to look at the movement of signaling molecules within the cells," she said.

Robey, with another colleague, Philippe Bousso, last year published a review in the journal Immunity describing the contributions two-photo imaging has made to the field. Robey and Witt publish their current study in the May 3 issue of the Public Library Of Science-Biology.

Two-photon imaging is a variation on the standard technique of labeling cells with fluorescent dye and then hitting them with a laser that makes
'"/>

Source:University of California - Berkeley


Page: 1 2 3 4 5

Related biology news :

1. A bacterial genome reveals new targets to combat infectious disease
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
4. NYU study reveals how brains immune system fights viral encephalitis
5. Study reveals new technique for fingerprinting environmental samples
6. Study reveals dramatic difference between breast cancers in US and Africa
7. UCSD research reveals mechanism involved with type of fatal epilepsy
8. Study reveals candidate targets for anti-retroviral therapeutics
9. Chimp genome reveals a retroviral invasion
10. Survey reveals women and doctors arent talking about HPV
11. Bioinformatics reveals new gene regulation system
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New tool reveals secrets migrating cells

(Date:7/11/2014)... from the Wildlife Conservation Society shows that no-take ... valuable species such as lobster, conch, and fish ... nearby reef areas. , The reporttitled "Review of ... of research literature from no-take areas around the ... Dahlgren, a recognized expert in marine protected areas ...
(Date:7/11/2014)... 11, 2014--Researchers at the Department of Energy,s Oak ... awards, presented by R&D Magazine in recognition of ... awards recognize the tremendous value of our National ... and development at the National Labs continues to ... pursue the scientific and technological innovations necessary to ...
(Date:7/11/2014)... New South Wales, Australia when NASA,s Aqua satellite passed ... July 11 (12:35 p.m. local time/11:35 p.m. EDT on ... Wales (NSW), the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... spotted smoke (light brown) from various fires. Actively burning ... red. , The New South Wales, Australia Government website ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4
... couches tested in a Duke University-led study contained potentially toxic or ... Among the chemicals detected was "Tris," a ... on animal studies. "Tris was phased out from ... risks, but it still showed up in 41 percent of the ...
... peer-reviewed study of the largest number of flame retardants ever ... at least one flame retardant that exceeded a federal health ... publish the study online on November 28, 12:01am Eastern. , ... for 49 flame retardant chemicals in household dust, the main ...
... motivations to serve their kids vegetables. A new Cornell ... simply serving vegetables with dinner, the main course would taste ... and attentive. , "Most parents know that vegetables are ... dinners," said lead author Brian Wansink, PhD, the John Dyson ...
Cached Biology News:Potentially toxic flame retardants found in many US couches 2New study: Many flame retardants in house dust -- unsafe levels 2New study: Many flame retardants in house dust -- unsafe levels 3
(Date:7/10/2014)... effect in bilayer graphene and shown that this exotic ... field. , The fractional quantum Hall effect, which ... exposed to large magnetic fields, is a striking example ... as a single system. However, while the basic theory ... this collective behavior remain not well understood, in part ...
(Date:7/10/2014)... can sit upside down forever. Nanophysics makes sure of that. ... article just published in Physical Review E . Knowledge ... spiders that seem to be able to sit still forever, ... many years. We will soon be able to buy smart ... foot. But the fact is, sooner or later the grip ...
(Date:7/10/2014)... by researchers at the University of Illinois at ... governing the interplay of spin and heat at ... ultrafast spintronic devices for data storage and information ... well as spin-angular momentum. In a typical charge ... no spin current," explained David Cahill, a professor ...
(Date:1/15/2014)... akin to assembling a club sandwich at the ... researchers have succeeded in crafting a uniform, multi-walled ... foam commonly used in upholstered furniture and other ... polyurethane foam was reduced 35 percent compared with ...
Breaking Biology Technology:Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... Technology, Inc. announced today that Jim Bullock has been ... company.  Before joining Zyga Technology, Jim was President and ... Boston Scientific.  Prior to Atritech, Jim was President and ... St. Jude Medical.  (Logo: http://photos.prnewswire.com/prnh/20110118/CG30384LOGO ...
... BEIJING, January 16, 2012 Elsevier, ... information products and services, announced today that its ... management, NursingChina , is now available online. ... online reference product available in China, featuring skills ...
... in a wide variety of applications from food ... applications. Thermal analysis is routinely used to analyze ... to use nanostructured materials has made bulk techniques ... force microscope-based technique called nanoscale thermal analysis (nanoTA) ...
Cached Biology Technology:Zyga Technology, Inc. Announces the Appointment of Jim Bullock as President and CEO 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 3Magnetic actuation enables nanoscale thermal analysis 2
... Anti-NY-ESO-1, clone E978 ... NM_001327 Immunogen : ... Formulation: mouse ascites with ... Assurance: routinely evaluated by ...
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
EnzChek Ultra Xylanase Assay Kit *500 assays*...
Defender against cell death 1...
Biology Products: