Navigation Links
New therapy for HIV/AIDS eliminates needles and excessive toxicity

A team led by Johns Hopkins scientists has found the first clear evidence that the process behind the human immune system's remarkable ability to recognize and respond to a million different proteins might have originated from a family of genes whose only apparent function is to jump around in genetic material. "Jumping genes" essentially cut themselves out of the genetic material, and scientists have suspected that this ability might have been borrowed by cells needing to build many different proteins from a specific, single set of instructions -- the key to recognizing a million immune-stimulating proteins. But until now, no jumping gene was known to behave just right.

Writing in the Dec. 23 issue of Nature, the researchers show that a jumping gene called Hermes, still active in the common house fly, creates changes in DNA very much like those created by the process behind antigen recognition. "Hermes behaves more like the process used by the immune system to recognize a million different proteins, called antigens, than any previously studied jumping gene," says Nancy Craig, Ph.D., professor of molecular biology and genetics in Johns Hopkins' Institute for Basic Biomedical Sciences and a Howard Hughes Medical Institute investigator. "It provides the first real evidence that the genetic processes behind antigen diversity might have evolved from the activity of a jumping gene, likely a close relative of Hermes." Recognition of so many antigens allows the immune system to fight infection and distinguish friend from foe. The "big picture" behind this ability is that cells build proteins called antibodies that bind to particular antigens, but the early steps of that process have been difficult to study. Hermes should help reveal some secrets of this process, the researchers say. "The immune system takes an approach to protein building similar to that of diners creating a meal at a cafeteria, but how the immun
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
9. Gene therapy for Parkinsons disease moves forward in animals
10. Pulsating ultrasound enhances gene therapy for tumors
11. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New therapy for HIV AIDS eliminates needles and excessive toxicity

(Date:5/17/2013)... Societies for Experimental Biology (FASEB) released a new ... trends highlighting the devastating impact of sequestration on the ... follows a May 15th Senate Appropriations Committee hearing featuring ... the $1.6 billion cut the agency sustained in FY ... on the scientific community." , According to data ...
(Date:5/16/2013)... (May 17, 2013) Illustrating a commitment to ... American Gastroenterological Association (AGA) Research Foundation has announced ... Research Fellowship Award recipients. Supported by the National ... (NIDDK), this new award helps underrepresented minority students ... and nutrition research. , "By establishing this new ...
(Date:5/16/2013)... Bethesda, MD FASEB MARC (Maximizing Access to ... recipients for The Society for Developmental Biology (SDB) ... 16-20, 2013. These awards are meant to promote ... underrepresented groups into the mainstream of the basic ... young scientists at the SDB 2013 Annual Meeting. ...
Breaking Biology News(10 mins):Underrepresented minority students receive fellowships in digestive disease and nutrition research 2
... constrictors, University of Cincinnati researchers put snakes to work on ... they might move around on branches and vines to gather ... by Greg Byrnes, a University of Cincinnati postdoctoral fellow in ... UC professor of biology, are published in the December issue ...
... are picky eaters: More than half of all species are ... -- between birth and adulthood. And a new study by ... Barbara, finds this pattern has major implications for the survival ... With thousands of species facing Earth,s sixth major mass extinction, ...
... the rise in young adults. Using technology to combat ... Weight Management Research Center will offer the IDEA (Innovative ... seven clinical trials to be funded by the National ... Institute. NIH,s Early Adult Reduction of Weight through ...
Cached Biology News:Snakes on a rope: Researchers take a unique look at the climbing abilities of boa constrictors 2Study: Ecological effects of biodiversity loss underestimated 2Pitt researcher receives NIH funding for technology-enhanced weight-loss program 2Pitt researcher receives NIH funding for technology-enhanced weight-loss program 3
(Date:5/17/2013)... 2013  Insero Health, Inc., a company developing natural ... related neurological disorders, is today reporting top-line results from ... in patients with drug-resistant epilepsy.  The data are being ... Xll meeting by Dr. Steven Schachter ... Scientific Advisory Board.  In this study, INS001 appeared safe ...
(Date:5/17/2013)... Rust removal is one of home maintenance's essential processes. ... damaged. To help rust contractors make it less expensive, My ... remover it called Rusterizer. It announced that for this ... My Cleaning Products explained that rust could damage items in ... The first one, it said, happens when rust forms ...
(Date:5/16/2013)... ISPE announced today that ... the newly created position of Vice President of ... be responsible for stimulating ISPE’s revenue growth by ... Society’s Member-led and staff-driven business model, initiating integrated ... membership and product marketing. , “Barbara joins ISPE ...
(Date:5/16/2013)... Cambridge Healthtech Institute will host its ... at the Renaissance Waterfront Hotel in Boston, MA. ... look at the current strategies and innovations for optimizing ... Leaders in the field will reveal how their work ... greater specificity and efficiency. , “In this age of ...
Breaking Biology Technology:Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy 2Organic-Based Rust Remover Cuts Down Price by 10%, My Cleaning Products Details Mechanics How to Get the Discount 2ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2
... Inc. (OTC/BB: TBIO) today reported financial results for the three ... Second Quarter Financial ResultsNet sales for the ... 50 percent compared with $5.1 million for the same period ... of net sales, compared with gross profit of $2.5 million ...
... 11, 2011 The American College of Medical Genetics ... Online Live Learning Center , which will bring online ... This valuable, on-demand resource brings the latest educational programming ... such as the Genetics Review Course and Annual Meeting ...
... Md., Aug. 11, 2011 GenVec, Inc. (Nasdaq: ... approved the replacement of its Stockholder Rights Plan through the ... Plan is to become effective on September 7, 2011, which ... to expire. The new Rights Agreement was adopted in connection ...
Cached Biology Technology:Transgenomic Reports Second Quarter Financial Results 2Transgenomic Reports Second Quarter Financial Results 3Transgenomic Reports Second Quarter Financial Results 4Transgenomic Reports Second Quarter Financial Results 5Transgenomic Reports Second Quarter Financial Results 6Transgenomic Reports Second Quarter Financial Results 7Transgenomic Reports Second Quarter Financial Results 8Transgenomic Reports Second Quarter Financial Results 9ACMG Announces New Online Live Learning Center: Will Bring Genetics and Genomics Education to Varied Health Professionals 2GenVec Renews Stockholder Rights Plan 2GenVec Renews Stockholder Rights Plan 3
... strip ejector is a unique product that ... from their holder. Linkage: This CLS number ... easily match Cornings product number. If showing ... old Sigma-Aldrich number (Z71,314-7) or contact customer ...
... This benchtop ductless exhaust hood ventilates ... safe indoor release of exhaust. Bonded ... Over 28" of vertical clearance (with ... Includes polypropylene spill tray; options include ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... The ideal modular cleanroom for biological ... that require cleanliness (to Class 10/ISO ... precision-joined to create ultra-smooth surfaces that ... disinfect. One-inch radius corners simplify cleaning. ...
Biology Products: