Navigation Links
New therapy for HIV/AIDS eliminates needles and excessive toxicity

A team led by Johns Hopkins scientists has found the first clear evidence that the process behind the human immune system's remarkable ability to recognize and respond to a million different proteins might have originated from a family of genes whose only apparent function is to jump around in genetic material. "Jumping genes" essentially cut themselves out of the genetic material, and scientists have suspected that this ability might have been borrowed by cells needing to build many different proteins from a specific, single set of instructions -- the key to recognizing a million immune-stimulating proteins. But until now, no jumping gene was known to behave just right.

Writing in the Dec. 23 issue of Nature, the researchers show that a jumping gene called Hermes, still active in the common house fly, creates changes in DNA very much like those created by the process behind antigen recognition. "Hermes behaves more like the process used by the immune system to recognize a million different proteins, called antigens, than any previously studied jumping gene," says Nancy Craig, Ph.D., professor of molecular biology and genetics in Johns Hopkins' Institute for Basic Biomedical Sciences and a Howard Hughes Medical Institute investigator. "It provides the first real evidence that the genetic processes behind antigen diversity might have evolved from the activity of a jumping gene, likely a close relative of Hermes." Recognition of so many antigens allows the immune system to fight infection and distinguish friend from foe. The "big picture" behind this ability is that cells build proteins called antibodies that bind to particular antigens, but the early steps of that process have been difficult to study. Hermes should help reveal some secrets of this process, the researchers say. "The immune system takes an approach to protein building similar to that of diners creating a meal at a cafeteria, but how the immun
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
9. Gene therapy for Parkinsons disease moves forward in animals
10. Pulsating ultrasound enhances gene therapy for tumors
11. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New therapy for HIV AIDS eliminates needles and excessive toxicity

(Date:8/20/2014)... 2014) Women who are poor experience higher cortisol ... elevated levels of the stress hormone, putting them ... according to a new research from the University of ... the American Journal of Human Biology , is ... it directly to the socioeconomic status of their mothers ...
(Date:8/20/2014)... In leaves, photosystem 1 (PS1) absorbs light and ... of carbon dioxide to biomass. Photovoltaic devices, mostly ... light but produce electricity. One approach for the ... replacing the semi-conductor with the isolated membrane protein ... isolates a highly stable PS1 from thermophilic cyanobacteria ...
(Date:8/19/2014)... improve students, chances of completing introductory biology courses ... (UH) implemented a comprehensive student success program, employing ... , Through a grant from the Texas ... Biology and Biochemistry embarked on a pilot program ... non-majors and "Introductory Biology" for science majors. These ...
Breaking Biology News(10 mins):CU Denver researcher shows economic disparities impact infant health 2A semi-artificial leaf faster than 'natural' photosynthesis 2University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3
... more corals and fish generate predictably greater levels of ... has important implications for understanding the behaviour of young ... environmental health by listening to reefs. Contrary to ... places, with fish and invertebrates producing clicks and grunts ...
... SALT LAKE CITYResearchers at Huntsman Cancer Institute (HCI) at the ... necessary for the maintenance and repair of the cell,s cytoskeleton, ... of the cell. The research has implications for cancer, as ... often associated with disease. The research was published in the ...
... failure of the Deepwater Horizon oil well last spring, nearly ... of Mexico to contain the spill. While preliminary reports suggest ... effect of such a massive volume of dispersant on ecosystems, ... a University at Buffalo researcher with expertise in how the ...
Cached Biology News:Taking the pulse of coral reefs 2Study offers first explanation of how cells rapidly repair and maintain structure 2A less toxic, more efficient dispersant is scientist's goal 2
(Date:8/20/2014)... that American Indians largely were wiped out by diseases ... brought to the New World by European explorers., One ... lived in the Americas shortly before Europeans arrived, and ... diseases., But new research led by anthropological geneticists Anne ... the University of Tubingen in Germany indicates the diagnosis ...
(Date:8/20/2014)... 2014  PAREXEL International Corporation (NASDAQ: PRXL ... the Baird Healthcare Conference in New York.  Ingo ... will be making a presentation on PAREXEL and discussing ... 3, 2014. A live webcast of the ... PAREXEL,s website at www.PAREXEL.com in the Upcoming ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient Outcome ... myPROpad™ ePRO tablet with the addition of a touchscreen ... widely used and well-respected Patient Reported Outcome (PRO) instruments ... used during clinical trials and in other health care ... to demonstrate Health-Related Quality of Life outcomes (HRQoL) resulting ...
(Date:8/19/2014)... A Geisinger researcher on a personal crusade ... for Disease Control and Prevention (CDC) award recognizing his ... Joseph Boscarino , Ph.D. MPH, senior ... of researchers nominated for the Centers for Disease Control ... Data Methods and Study Design. "Hepatitis C ...
Breaking Biology Technology:Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3PAREXEL International To Present At Baird Healthcare Conference 2EQ-5D™ Assessment Now Available for iPad 2Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... research laboratories, filtration techniques are performed to sterilize and clarify ... and purify samples for processing. In most cases, filtration can ... The majority of filtration tasks require low ... (25 28Hg). A number of plastic labware and filter ...
... , Sequence information ... understanding of the human genome. Empowered by the expanded ... increasingly effective tool for identifying factors that influence disease ... differences between individuals have a strong genetic component. The ...
... , , ... One of the major difficulties in analyzing the proteome ... proteins present in the sample. Human serum albumin (HSA) constitutes 57-71% of ... two proteins alone clears about 75% of the total protein present in ...
Cached Biology Technology: Improving the Efficiency of Common Filtration Tasks in your Laboratory 2 Improving the Efficiency of Common Filtration Tasks in your Laboratory 3SNPs Powerful Tools for Association Studies 2SNPs Powerful Tools for Association Studies 3SNPs Powerful Tools for Association Studies 4SNPs Powerful Tools for Association Studies 5SNPs Powerful Tools for Association Studies 6SNPs Powerful Tools for Association Studies 7SNPs Powerful Tools for Association Studies 8SNPs Powerful Tools for Association Studies 9SNPs Powerful Tools for Association Studies 10SNPs Powerful Tools for Association Studies 11SNPs Powerful Tools for Association Studies 12SNPs Powerful Tools for Association Studies 13SNPs Powerful Tools for Association Studies 14SNPs Powerful Tools for Association Studies 15SNPs Powerful Tools for Association Studies 16SNPs Powerful Tools for Association Studies 17SNPs Powerful Tools for Association Studies 18SNPs Powerful Tools for Association Studies 19Affinity Depletion Cartridges for Removal of Human Serum Albumin and Immunoglobulins from Human Serum 2Affinity Depletion Cartridges for Removal of Human Serum Albumin and Immunoglobulins from Human Serum 3Affinity Depletion Cartridges for Removal of Human Serum Albumin and Immunoglobulins from Human Serum 4Affinity Depletion Cartridges for Removal of Human Serum Albumin and Immunoglobulins from Human Serum 5
Attachments: Clip bar for tubes 10 to 19 mm in diameter Overall Dimension Height IC: 6 (15.2) Overall Dimension Length IC: 18.5 (46.9) Overall Dimension Width IC: 4 (10.2)...
BD FastImmune EDTA Solution. Applications: Flow Cytometry Storage Temperature: Refrigerate(2 to 8C)...
... GRADE ,5-Bromo-4-chloro-3-indoxyl-beta-D-galactopyranoside C 14 H ... 6 ,M.W.= 408.63 ,Assay: Greater ... in DMF) ,Biological Activity: Blue color ... Analysis: Agrees with theoretical values ,Thin ...
Antibodies were affinity purified using epitopes specific to RFC1 immobilized on solid support....
Biology Products: