Navigation Links
New test to detect rare proteins in blood

ble to detect tumors at very early stages so that tumor emergence or reoccurrence can be rapidly treated or even prevented.

Greene's laboratory established many of the principles of targeted therapy for Her2/neu tumors and the prototype antibodies that led to the development of Herceptin, a similar antibody molecule that was created by Genentech. The Greene laboratory also previously showed that early treatment of Her2/neu tumors with targeted monoclonal antibodies in animal models led to far more significant prevention of tumor growth as well as tumor emergence and reoccurrence.

Greene stresses that early treatment is far more effective than treating advanced tumors with the same antibodies. Recent clinical trials support the notion that early treatment prevents tumor reoccurrence in women with breast tumors. FACTT technology represents a way to couple early diagnosis with early treatment to prevent tumor emergence.

Detecting Her2/neu in humans for breast cancer

The most widely used clinical Her2/neu tests are IHC (immunohistochemistry) and FISH (fluorescence in situ hybridization). However, both FISH and IHC are complex, time-consuming tests.

Patients who test positive for Her2/neu using FISH or IHC have responsive rates of about 35 percent to the cancer drug Herceptin. Monitoring Her2/neu status from the blood with a powerful technology such as FACTT represents an alternative approach compared to IHC or FISH, say the researchers.

Pre-treatment Her2/neu levels correlate with tumor size and the extent of disease. Post-treatment Her2/neu levels predict disease-specific survival. A more sensitive assay could more accurately allow treatment of humans with breast cancer and allow treatment more quickly if the tumor reoccurs.

The researchers collected blood samples from healthy women and breast cancer patients who did or did not overexpress Her2/neu, as detected by IHC and FISH. When using the new FACTT m
'"/>

Source:University of Pennsylvania School of Medicine


Page: 1 2 3 4 5

Related biology news :

1. Novel technology detects human DNA mutations
2. Researchers find how protein allows insects to detect and respond to pheromones
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Development of portable infectious disease detector
5. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
6. Yale researchers identify molecule for detecting parasitic infection in humans
7. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
8. Products containing specific probes for detecting alternative splice forms protected
9. Nanoparticles offer new hope for detection and treatment
10. Test for early detection of prostate cancer shows promise
11. Confocal imaging promises early detection of skin cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New test detect rare proteins blood

(Date:9/29/2014)... that the exposure to tar tended to be lower ... Similarly, exposure to nicotine tended to be lower. ... cigarette in several countries around the world. Previous studies ... in the smoke of these cigarettes are lower than ... chemicals in the smoke are not necessarily linked to ...
(Date:9/29/2014)... According to a NASA story from 2009, "human activities in ... fire emissions issue. Palm oil is increasingly grown for use ... fats in processed foods. It has become the most widely ... in recent years to surpass that of soybean oil. , ... has to be cleared to grow the crop, and the ...
(Date:9/29/2014)... team says recently identified radiation detection properties of a ... for homeland security and medical advances. , In a ... of Optics Letters , UT Arlington Physics Professor ... to fabricate transparent nanoscintillators by heating nanoparticles composed of ... formed. A scintillator refers to a material that ...
Breaking Biology News(10 mins):Slim cigarette smokers not exposed to more harmful chemicals 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3
... 2008The 2008 American Society for Microbiology (ASM) BD ... presented to Stephen C. Edberg, Professor, Department of ... of Medicine, and Director, Clinical Microbiology Laboratory, Yale-New ... award recognizes a distinguished scientist for research accomplishments ...
... be the first recipient of a prestigious award given by ... Meeting of the Ecological Society of America on August 3. ... an outstanding record of informing their political decision-making with ecological ... figure that has a sharp appreciation for local and global ...
... 28, 2008The 2008 American Society for Microbiology (ASM) ... is presented to Steven A. Rosenberg, Chief of ... Services University of the Health Sciences, and Professor ... and Health Sciences. Sponsored by Abbott Laboratories Diagnostics ...
Cached Biology News:American Society for Microbiology honors Stephen C. Edberg 2American Society for Microbiology honors Steven A. Rosenberg 2
(Date:9/30/2014)... Back in the 1970’s, many companies calculated their office ... included space for circulation and file storage. “It was ... Nidea Corporate Real Estate / ITRA Global , a ... however, 250 square feet per employee became the norm. ... 175 to 225 square feet, and over the next few ...
(Date:9/29/2014)... of diagnostics today, with imaging techniques like MRI ... NMR (nuclear magnetic resonance) increasing steeply over the ... resolution and quality still limit these techniques because ... is hyperpolarization, which involves injecting the patient with ... the distribution and fate of specific molecules in ...
(Date:9/29/2014)... Research and Markets  has announced the ... & Services, End-User , Application - Global Forecast to ... The global oligonucleotide synthesis market is expected to reach ... growing at a CAGR of 9.8% from 2014 to ... the basis of products and services, applications, end users, ...
(Date:9/29/2014)... involve a range of resource and environmental problems. ... resin and a clever recycling strategy, Uppsala researchers ... alternative. Their study will be presented soon in ... think our discovery can open several doors to ... the future, says Daniel Brandell, Associate Professor at ...
Breaking Biology Technology:ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 3Smart, eco-friendly new battery to solve problems 2
... CAMBRIDGE, Mass., Jan. 13 Verenium Corporation,(Nasdaq: ... the development of next-generation cellulosic,ethanol and high-performance ... compliance with the continued listing requirements of ... that it had fallen out of,compliance with ...
... January 15th at 1:00PM PTNEW YORK, Jan. 13 ... announced that Michael S. Weiss, the Company,s Chairman and ... J.P. Morgan 27th Annual Healthcare Conference being held in ... Thursday, January 15th at 1:00pm PT and will be ...
... Jan. 13 Burnham Institute for Medical ... and license agreement with Johnson & Johnson ... The agreement is Burnham,s first broad-based partnership ... agreement, Burnham will provide J&JPRD with access ...
Cached Biology Technology:Verenium Regains Compliance With Nasdaq Continued Listing Requirement 2Verenium Regains Compliance With Nasdaq Continued Listing Requirement 3Keryx Biopharmaceuticals to Present at the J.P. Morgan 27th Annual Healthcare Conference 2Burnham Announces Assay Development and License Agreement with Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 2
Human SDNSF/MCFD2 Biotinylated Affinity Purified PAb...
... Nucleon HT, 1 kit. Facilitates the ... paraffin-embedded sections and hard tissue requiring proteinase ... high quality DNA from 50 preparations of ... Category: DNA/RNA Synthesis & Purification, Purification and ...
Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5), mRNA....
Phospho-p70 S6 Kinase (T229) Affinity Purified PAb...
Biology Products: