Navigation Links
New technology addresses female fertility preservation

Women at risk for infertility, such as those needing cancer treatment, can freeze mature, fertilized eggs, but the process can take up to six weeks and for some this delay of treatment is not an option.

Immature follicles (the female egg and surrounding somatic cells) can be preserved at any time but are difficult to mature when removed from their normal environment.

A team of scientists from Northwestern University has developed a three-dimensional culture system that encapsulates follicles and allows immature eggs to grow and mature in vitro. (A follicle is a small spherical group of specialized support cells surrounding each egg.) This novel technology has already led to the live birth of healthy mice from in vitro grown follicles.

The results are published online this month by the journal Tissue Engineering.

The study shows that follicles grown individually in a three-dimensional biomaterial called alginate maintain normal connections between follicle and egg, resulting in the development of eggs, which can be fertilized and ultimately lead to healthy embryos and the birth of live mice. Previously developed methods of growing follicles or eggs outside of the body do not provide the three-dimensional support to maintain the follicle structure in which the egg must grow.

"While the research is in its early stages, this work has implications for the preservation of fertility for women and girls with cancer," said Teresa K. Woodruff, Professor of Neurobiology and Physiology who led the study together with Lonnie D. Shea, Associate Professor of Chemical and Biological Engineering. "This system establishes a core technology for human egg banks for preservation of fertility."

The technology mimics the ovary and its environment. Follicles (each follicle has one egg) from mice were grown in vitro until fully matured by providing the follicles and eggs with the necessary hormones for development while maintaining their norma l architecture. The eggs were then used for in vitro fertilization. The fertilized eggs were implanted into a foster mother that was of a different strain than the donor egg and sperm, resulting in babies with a different coat color, proving that the births were the result of the cultured embyros. Both male and female offspring were fertile.


'"/>

Source:Northwestern University


Related biology news :

1. Novel technology detects human DNA mutations
2. Novel antiviral technology inhibits RSV infection in mice
3. The BIOS Initiative - open source biotechnology is born
4. Revolutionary nanotechnology illuminates brain cells at work
5. Study: homemade gene expression technology unreliable
6. First technology to remove prions that cause vCJD from blood launched
7. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
10. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
11. Vietnam war technology could aid elephant conservation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
Breaking Biology Technology: