Navigation Links
New technique could alter field of mouse genetics

other genes effectively. Inserted into mouse embryos, the transposon and its cargo was inherited through five generations. PiggyBac can also be removed from its place in the family tree by breeding a mouse with another that carries the enzyme necessary to excise the jumping gene.

"We do not know why the P element did not work in mammalian organisms, and we do not know why this particular one works," Xu said, "but this system is a dream tool for geneticists working with vertebrates and mammals."

PiggyBac inserts randomly into the genome, with a clear preference for genes. This bodes well for its use in mutating genes and for identifying unrecognized genes in places of the genome that have been especially difficult to sequence. Furthermore, the markers it carries make it easy to find. In Xu's lab, the jumping gene carried red fluorescent protein and an enzyme that changes the coat color of a white mouse to grey or black. The transposon acts as a genetic beacon, so researchers can easily track its location without having to sequence the entire genome, as can happen with the chemical mutagen technique.

In three months, the two graduate students who led the project, generated knockout mice for each of 75 different genes. Xu, Min Han, an HHMI investigator at the University of Colorado, Boulder, and Yuan Zhuang of Duke University, and their colleagues at Fudan University are in the process of scaling up piggyBac for the Mouse Functional Genome Project, which is aiming to mutate the majority of mouse genes at a state-of-the-art research facility in China. Xu expects the technique to be particularly useful for animal models of genetically complex diseases, such as diabetes, where many genes contribute to the disease process.


'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. New lab technique identifies high levels of pathogens in therapy pool
2. Brain-mapping technique aids understanding of sleep, wakefulness
3. Study reveals new technique for fingerprinting environmental samples
4. Researchers pioneer new gene therapy technique using natural repair process
5. Newer imaging techniques may lead to over-treatment
6. Gene silencing technique offers new strategy for treating, curing disease
7. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
8. Researchers devise new technique for creating human stem cells
9. New technique rapidly detects illness-causing bacteria
10. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
11. New technique may speed DNA analysis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New technique could alter field mouse genetics

(Date:7/31/2015)... Die 10. internationale Konferenz zu Genomik (ICG-10, ... vom 22. bis 25. Oktober 2015 in ... Die Konferenz feiert in diesem Jahr ihr ... ICG weltweit zu einem der einflussreichsten jährlichen Treffen ... dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen Zusammentreffen. ...
(Date:7/27/2015)... , July 27, 2015   Zynx Health ... experience-based clinical improvement solutions, today announced that its ... now available on Android smartphones and tablets. With ... post-care organizations can use ZynxCarebook to securely exchange ... condition, streamline care transitions to other care settings, ...
(Date:7/21/2015)... , July 21, 2015 Passwords ... as seen in the recent U.S. Office of ... solution to the infosec conundrum, but developers and ... stored. To address this dilemma, Biometrics-as-a-Service provider HYPR ... Biometric Tokenization SDK for third party integration. ...
Breaking Biology News(10 mins):Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4
... RIVERSIDE, Calif. Humans are conducting massive experiments on ... introducing exotic species, boosting nutrient concentrations, and altering climates. ... will give the Jane Block Distinguished Lecture in ... which he will discuss how our ability to assess ...
... May 7, 2013 /PRNewswire-iReach/ -- Glutathione is the ... oxidants and a large variety of other toxins and insults. ... enhancing glutathione levels in cells and tissues has simmered for ... oral supplementation is effective in increasing the body,s stores of ...
... For plants and animals forced to tough out harsh ... country is a refuge, a stable beneath-the-snow habitat that gives ... in a warming world, winter and spring snow cover in ... plants and animals that depend on the space beneath the ...
Cached Biology News:Public lecture at UC Riverside to discuss challenges in assessing human impact on ecosystems 2Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study 2Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements - Kyowa Study 3Decline in snow cover spells trouble for many plants, animals 2Decline in snow cover spells trouble for many plants, animals 3
(Date:7/30/2015)... ... July 30, 2015 , ... Leading regenerative ... study of its canine osteoarthritis stem cell product, currently under development for FDA ... and will be marketed in the US by Aratana. This product, termed AT-016, ...
(Date:7/30/2015)... , July 30, 2015 Ascendis ... company that applies its innovative TransCon technology to ... top-line results from a six-month Phase 2 study ... TransCon Growth Hormone in 53 treatment-naïve, pre-pubertal children ... "We are extremely pleased with the top-line results ...
(Date:7/30/2015)... ... 2015 , ... GEA's Pony™ NS2006L is a ... to 1500 bar. The sanitary design gauge of the NS2006L is well suited ... Pony™ NS2006L homogenizer is an ideal solution for the processing of nanoparticles, ...
(Date:7/29/2015)... SYDNEY , July 29, 2015 US-Australian ... NVGN ) today confirmed it is committed to progressing ... as soon as practicable and to ensure the Company ... Chief Executive Officer, Iain Ross , said the ... including the lead pre-clinical programs, discovery programs and academic ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10
... Derma Sciences,Inc (OTC Bulletin Board: DSCI), a provider of ... $34.1 million, an increase of 22 percent,over the $27.9 ... 34,percent, but due primarily to the costs of bringing ... marketing and sales staffs, the,Company reported a loss of ...
... Technologies Intelligently Integrate Sensor and System Data into the ... and Collaboration for Government Agencies to Protect ... Assets, Employees, and Citizens, ... of intelligent enterprise network technologies, today announced it,has partnered with ...
... YORK, April 1, 2008 WallSt.net,s 3-Minute Press,Show ... reporter, Tracee,Tolentino., Shows air Monday through ... Show features in-depth interviews with,public company executives on ... is designed to provide viewers with insight into ...
Cached Biology Technology:Derma Sciences Reports Fourth Quarter Year-End Results for 2007 2Derma Sciences Reports Fourth Quarter Year-End Results for 2007 3Derma Sciences Reports Fourth Quarter Year-End Results for 2007 4Derma Sciences Reports Fourth Quarter Year-End Results for 2007 5Augusta Systems Technologies Integrated into Cisco's Newly Launched Safety and Security Platform 2Augusta Systems Technologies Integrated into Cisco's Newly Launched Safety and Security Platform 3Featured Stocks on Today's Edition of WallSt.net's 3-Minute Press Show: BFNH, BKYI, RBCL 2Featured Stocks on Today's Edition of WallSt.net's 3-Minute Press Show: BFNH, BKYI, RBCL 3
... Application: For the efficient enrichment of ... tissue or cell culture. The isolated ... degradation and metabolic pathway analysis. Metabolic ... deficiency in children, cystic fibrosis and ...
Plasmid expressing the LacZ reporter gene....
... PYREX Fernbach-style culture flasks have triple baffles ... bottom to achieve maximal oxygen transfer to ... marking spot., A wide range of optional ... Polypropylene colored caps for ease of ...
...
Biology Products: