Navigation Links
New study shows measles immunization may prevent fatal brain infection

A new study has found wild-type measles virus in tissues from patients who died of a fatal brain infection, providing evidence against the notion that the strain of virus in the measles vaccine caused the infection. The study, in the November 15 issue of The Journal of Infectious Diseases, now available online, also concludes that vaccination against measles could prevent many more cases of the disease, known as subacute sclerosing panencephalitis, or SSPE, than previously thought.

Because persons have apparently contracted SSPE without ever knowingly having had measles, it could not be ruled out that the measles vaccine strain caused the infection. William Bellini, PhD, and colleagues at the Centers for Disease Control and Prevention (CDC), sought to evaluate that notion.

Brain tissue specimens from 11 patients suspected of having SSPE were examined. Five of the 11 patients with samples and 7 additional SSPE patients identified in case reports were related to infections during the resurgence of measles in the United States during a drop in measles vaccination rates between 1989 and 1991. The ages of the patients ranged from 5 to 36 years, with a mean of 14.

The researchers discovered wild-type measles virus in brain tissues from individuals with SSPE who had no previous diagnosis of measles and had been vaccinated. Case histories and demographics, when available, suggested that most of the individuals had very likely contracted measles prior to being vaccinated.

The fact that 12 SSPE patients identified in the study had measles between 1989 and 1991 raises the incidence of measles-induced SSPE to a level approximately 10 times higher than the statistic often cited. That figure, based on data available in 1982, estimated that 8.5 in 1 million persons contracted SSPE, a rate grossly underestimating the risk, now thought to be between 7 and 11 per 100,000.

The higher incidence could be due to an underreporting of diagnosed measles cases, despite clinical guidelines on reporting infections. Other possibilities include a higher incidence of measles during the 1989-1991 resurgence in the population with the highest risk for SSPE, namely children under the age of five, or because wild-type viruses of the genotype identified are more likely to cause SSPE.

The measles vaccine is known to be highly effective. Two doses provide immunity to 99 percent of those vaccinated. Since the risk of SSPE was much higher than originally estimated, and since the vaccine had not caused SSPE in the cases studied, the researchers concluded that measles vaccination programs prevent many more of the fatal brain infections than previously thought.

In an accompanying editorial, Samuel L Katz, MD, of Duke University, who was part of the team that developed the measles vaccine, strongly urged support for global efforts to reduce measles mortality through immunization programs. Despite recent reductions in the worldwide toll of measles, he noted, the disease still accounts for almost half of the 1.6 million annual childhood deaths due to vaccine-preventable diseases.


'"/>

Source:Infectious Diseases Society of America


Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/12/2016)... , Dec. 12, 2016  Researchers at Trinity ... for graphene by combining the material with Silly ... sensitive pressure detector able to sense pulse, blood ... small spider.  The research team,s ... be read here:  http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/7/2016)... 7, 2016 According to a new market research report ... (Facial Expression, Voice Recognition), Service, Application Area, End User, And Region - Global ... from USD 6.72 Billion in 2016 to USD 36.07 Billion by 2021, at ... Continue Reading ... MarketsandMarkets Logo ...
(Date:12/7/2016)... 2016   Veridium , a leader in ... new CEO James Stickland . Stickland, a ... experience, has served in senior executive roles for ... in expanding a pipeline of venture capital and ... recently served as managing director of U.K.-based fintech ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... ... January 18, 2017 , ... BidMed, ... sell research and genetic testing lab equipment from two different leading institutes. This highly ... Northeast regions of the United States. This 1-day online auction will take place ...
(Date:1/18/2017)... ... ... Thirty-six startup companies in University City and Center City have been awarded nearly ... in 2016 as part of the Keystone Innovation Zone (KIZ) Tax Credit Program. ... the highest number of awards to the largest number of companies in the 10 ...
(Date:1/18/2017)... 2017  HUYA Bioscience International, (HUYA), the leader in ... pharmaceutical innovations, announced today a strategic collaboration agreement ... Company (referred to as CAS Innovation). The collaboration will ... leading scientists at CAS to meet the medical needs ... the first company to have recognized China,s ...
(Date:1/18/2017)... Jan. 18, 2017 /PRNewswire/ - SQI Diagnostics Inc. ... diagnostics company that develops and commercializes proprietary technologies ... the "Company"), today announced that Cameron Prange ... has resigned from its Board of Directors.  Mr. ... securities regulations that have limited both his ability ...
Breaking Biology Technology: