Navigation Links
New study identifies key gene in development of connections between brain and spinal cord

A new study, presented at the American College of Neuropsychopharmacology's (ACNP) Annual Meeting, has identified a specific gene that is necessary for the development of connections between the brain and the spinal cord. This research, conducted by Stanford University through a grant from the National Institutes of Health (NIH), could be critical for future understanding of the development of the human brain and possibly the treatment of spinal cord injuries.

During fetal development, genes "instruct" nerve cells on how and where to develop. Researchers examined the plasticity of fetal cells to better understand at what developmental period cells are specialized (i.e., limited in their ability to take on new characteristics) or undifferentiated (i.e., able to be take on new function or characteristics).

In attempting to uncover key developmental moments in the brain, the team removed or "knocked out" the gene for Fezl, a DNA-binding protein, to observe its effect on brain development. Mice were used as the animal model because they serve as a powerful genetic representation of human brain circuitry. The major finding of the study was that in developing mice that lack Fezl, normal connections to the spinal cord failed to form. Instead, the brain cells that usually form the spinal cord made inappropriate connections to other parts of the brain. This result led the researchers to determine that Fezl is necessary for proper development of neural connections to the spinal cord.

"Normally, Fezl is required for certain brain cells to grow along the pathway that leads into the spinal cord. In the mice lacking the gene for Fezl, this pattern of spinal cord development was not observed," explained senior study author Susan McConnell, Ph.D., Professor of Biological Sciences at Stanford University. "These findings could have important implications in the future treatment of spinal cord injuries."

Though these findings have yet to
'"/>

Source:GYMR


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition ... individuals. Facial recognition system measures the overall facial ... edges, mouth, and the distance between eyes. Facial ...
(Date:12/10/2014)... You,ve been here before: you desperately need to ... password, site key or the answer to your secret question. ... Today, Hoyos Labs , a digital ... finally put an end to the frustration that comes with ... 1U leverages a user,s smartphone to acquire his or her ...
(Date:12/10/2014)... December 9, 2014   ... Platform   Jifflenow, ... scheduling solutions for business-to-business (B2B) events, today announced ... in mobile near-field communication (NFC), Bluetooth low energy ... (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... spectrometry for decades to determine the chemical composition ... to identify viruses, and never in complex environmental ... Bloomberg School of Public Health recently demonstrated that ... applied for this purpose. Using a two-step process, ...
... Scientists have used mass spectrometry for decades to ... has it been used to identify viruses, and ... at the Johns Hopkins Bloomberg School of Public ... the potential to be applied for this purpose. ...
... apparently thwarts a disease-causing invader that creates a fuzzy ... same gene provides access to a different type of ... his collaborators in Austria and North Carolina identified the ... a defense against disease. The gene and its defense ...
Cached Biology News:Ancient ants arose 140-168 million years ago 2Researchers use mass spectrometry to detect norovirus particles 2Gene thwarts some pathogens, gives access to others, could save crops 2Gene thwarts some pathogens, gives access to others, could save crops 3
(Date:12/22/2014)... , Dec. 22, 2014 GenomeDx Biosciences today ... Prostate Cancer Classifier, a genomic test for prostate cancer, ... high-risk men managed by radical prostatectomy without adjuvant therapy. ... is relatively uncommon, using tumor genomics to identify these ... disease is an important advance. The study has been ...
(Date:12/22/2014)... ITRA Global, one of the largest ... real estate, has further expanded its global reach with ... Brisbane, Western Australia, reports Mylinda Vick, CCIM, Chairman of ... Global / ACORPP (Australian Corporate Property and Projects) , ... property services to a wide range of clients in ...
(Date:12/19/2014)... 2014 Charm Sciences is pleased to ... Detection of Aflatoxin M1 in raw commingled milk is ... party validation. The peer reviewed report of the validation ... for Agricultural and Fisheries Research (ILVO-T&V) has been published ... B1, the most toxic aflatoxin and a known carcinogen, ...
(Date:12/19/2014)... 19, 2014  Roche (SIX: RO, ROG; OTCQX: RHHBY) ... (Bina), a privately held company based in ... provides a big data platform for centralized management ... Bina,s proprietary on-market Genomic Management Solution, Bina-GMS 1 ... perform fast and scalable analyses to maximize the ...
Breaking Biology Technology:Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3
... 28 Boston,Scientific Corporation (NYSE: BSX ) ... that Boston Scientific has completed its acquisition of ... April 16.,Under the terms of the transaction, all ... per share in cash, for a total of,approximately ...
... N.J., May 28 National Stem Cell,Holding, Inc. (OTC: ... steps to,change its name to Proteonomix, Inc. The change ... Michael Cohen, President/CEO, stated: "Our new name reflects the ... development stage and,commencing the commercialization of our technologies. These ...
... Provides Additional Global Corporate Finance, Management and ... Manufacturing ... (TSX: NVN) announced today the appointment of Gordon H.,Busenbark to ... chief financial officer of Xytis Pharmaceuticals, a privately,held development-stage specialty ...
Cached Biology Technology:Boston Scientific Completes Acquisition of CryoCor 2Boston Scientific Completes Acquisition of CryoCor 3National Stem Cell Holding, Inc. Announces the Change of Its Name to Proteonomix, Inc. 2National Stem Cell Holding, Inc. Announces the Change of Its Name to Proteonomix, Inc. 3Nventa Appoints Gordon H. Busenbark to Board of Directors 2
SCCRO (S-17)...
Packaging: 6 bottles for 1 l ready-to-use-solution ID clarifier: ready-to-use solution ...
... a group of enzymes important in the ... The enzymes protect cells against toxicants by ... to electrophilic xenobiotics, and thereby defend cells ... of the compounds. GST activity is present ...
Mouse monoclonal [HYB 232-02] to Protein S ( Abpromise for all tested applications). entrezGeneID: 5627 SwissProtID: P07225...
Biology Products: