Navigation Links
New stem-cell findings can help the body to cure itself

Researchers at Karolinska Institutet have identified an important mechanism that regulates how many new cells are produced by each intestinal stem cell. The study is published in the latest issue of the prestigious scientific journal, Cell. "This might eventually help us develop new drugs for things like neurological disorders and anaemia," says Professor Jonas Frisén.

In most organs of the body, old cells are continually being replaced by new. If too many new cells are produced, however, it can lead to overgrowth and tumour formation. Too few cells, on the other hand, can result in organ degeneration. It is therefore crucial that exactly the right number of cells are produced.

As many serious disorders cause a reduction in the production of new cells, scientists are keen to develop drugs that stimulate the process, which in turn could help the body to cure itself.

It has long been known that the new cells are often formed by immature cells known as stem cells, but the mechanism regulating the number of new cells produced has remained something of a mystery. However, in a new study to be published by Cell stem-cell researcher Jonas Frisén has succeeded in showing how the body's own stem cells do just this. Working alongside an American group of researchers, Professor Frisén and his team have identified a signal transduction process that regulates the degree of stem-cell division.

"Understanding how cell production is regulated increases our chances of producing drugs able to stimulate the endogenous production of new cells," says Professor Frisén.

He hopes that the new findings can be used to develop drugs that stimulate, for example, the formation of new nerve cells to treat conditions such as stroke and Parkinson's and skin cells to facilitate the healing of wounds. Professor Frisén is best known for his research on cerebral stem cells; the present study, however, has been carried out on stem cells in the intestine, one of th e organs in the body with the highest rates of cell renewal.

"We also know that blood, brain and skin stem cells express the genes that we now know to be important in the intestine," he says. "This suggests that the cell production mechanism can be the same for these stem cells too."

The next step for Professor Frisén and his group is therefore to study how blood and skin stem cells go about producing new cells.


'"/>

Source:Karolinska Institutet


Related biology news :

1. Researchers discover key to human embryonic stem-cell potential
2. Surprising findings reported about iron overload
3. Study findings offer potential new targets for antibiotics
4. Oops! Researchers publish new findings on the brains response to costly mistakes
5. Biodiversity key to sustainable biofuel according to University of Minn. researchers findings
6. New findings offer more complete view of breast cancer gene mutations in US population
7. New findings could lead to vaccine for severe malaria
8. New findings blow a decade of assumptions out of the water
9. New nano-canary in the nanotoxicology coalmine: The body itself
10. A bathroom that cleans itself
11. Smart genetic therapy helps the body to heal itself
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
Breaking Biology News(10 mins):
(Date:9/12/2017)... New Brunswick, NJ (PRWEB) , ... September 12, ... ... as one of the fastest growing b2b product testing and development companies will ... their expanded service offerings. , Contract Pharma is an ...
(Date:9/12/2017)... ... September 12, 2017 , ... It wasn’t just the San Diego temps that ... hot, as Lajollacooks4u has had a record-breaking number of guests for corporate cooking challenges, ... wide to celebrate company outings, family get-togethers, anniversaries and milestone birthdays. While all ...
(Date:9/12/2017)... ... September 12, 2017 , ... September 15, 2017. ... Nicholson, Head of the Department of Surgery and Cancer and Director of the ... Coulter Lecture. His presentation, “Analytical Science in Precision Medicine: Facing the Challenges ...
(Date:9/12/2017)... Wayne, PA (PRWEB) , ... September 12, 2017 , ... ... and growing life sciences teams, today announced that Tobias Massa, PhD has joined the ... pharmaceuticals, biotech, life sciences, and technology to his Board position. Most recently he served ...
Breaking Biology Technology: