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New species from old data

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Furthermore, the researchers say some of the protein peaks were found in regions of the spectra where, for technical reasons, mass spectrometry cannot be sampling proteins, and thus may be simply representing experimental “noise.?Such results may come about from such procedural problems as incomplete randomization of samples, Baggerly says.

The study raises a question that is broader than the effectiveness of the experimental ovarian cancer test, the researchers say. “Are we going to be able to measure what we want to measure??Baggerly asks. “Given issues in technology and a lack of standards, I think it will be a few years before we can know what works.?/p>

The study was funded by the National Cancer Institute.


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