Navigation Links
New species from old data

hers in the journal, Lancet. That study reported dramatic results using mass spectrometry to search for a pattern of proteins in blood. In several sets of blinded samples, the test detected all patients who had ovarian cancer and only misdiagnosed three healthy individuals.

But among others who subsequently tested the study’s data for reproducibility were Baggerly and his colleagues (Kevin Coombes, Ph.D., and Jeffrey Morris, Ph.D., from M. D. Anderson Cancer Center, and Sarah Edmonson, M.D., from Baylor College of Medicine). They say the issue centers on how the mass spectrometer data were analyzed.

A mass spectrometer is an instrument that can quantitatively measure the concentration of hundreds of proteins from a single sample. In short, it does this by using an electric current to propel ionized proteins toward a detector. The number of ions hitting the detector at each mass-to-charge ratio (also known as m/z ratio) is recorded to produce a protein spectrum. A peak in the graph of the spectrum represents a protein (the identity of which is often unknown).

The goal is to find a pattern of peaks that will distinguish between patients with cancer and those who are cancer-free. The authors of the Lancet study have reported different proteomic patterns in three separate data sets. Researchers at the State University of New York, Stony Brook, reanalyzed the data to look for reproducible patterns. In 2003, they reported finding a single pattern involving 18 peaks (or unidentified proteins) that could diagnose ovarian cancer across two of these data sets.

The M. D. Anderson researchers examined the quality of the data sets and concluded that this systematic protein pattern “is biologically implausible.?Baggerly explains that discriminatory peaks appear to be spread across the entire m/z spectrum in the second data set, but “changes in protein expression associated with cancer should affect only a few specific peaks, not the entire spectrum
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Same mutation aided evolution in many fish species, Stanford study finds
2. Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
3. Reservoirs may accelerate the spread of invasive aquatic species, researchers say
4. Small species back-up giant marsupial climate change extinction claim
5. Aggressive aquatic species invading Great Lakes
6. Bush, Cheney and Rumsfeld are now species of slime-mold beetles -- but strictly in homage
7. Internet viruses help ecologists control invasive species
8. An (ecological) origin of species for tropical reef fish
9. Ancient DNA helps clarify the origins of two extinct New World horse species
10. Invasive parasite destroying fish species
11. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New species from old data

(Date:7/30/2014)... Chemical Society (ACS) announced today that David L. Kaplan, ... Biomaterials Science & Engineering as editor-in-chief. With the ... new journal will feature high-quality research in the rapidly ... naturally derived materials that interact with living or biological ... reflects the tremendous growth in the field of biomaterials ...
(Date:7/30/2014)... Institute (SALSI), a joint venture between The University of ... Texas Health Science Center at San Antonio, has selected ... winners, Emily Boice from UTSA and Lei Huang from ... project titled, "Novel engineered ferritins for tracking and protecting ... Huang,s research is focused on finding a treatment for ...
(Date:7/30/2014)... HIV infection could be as simple as inserting a ... University of Washington bioengineers have discovered a potentially faster ... from contracting HIV. Their method spins the drug into ... moisture, releasing higher doses of the drug than possible ... , "This could offer women a potentially more effective, ...
Breaking Biology News(10 mins):ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... release is available in Spanish . ... acids and they play a fundamental role in all of ... they, therefore, carry out numerous functions in an organism: immunological ... (they form part of enzymes) and a long list of ...
... hold promise for improved early disease screening, cancer staging, therapeutic ... Ge Wang , director of Virginia Tech,s Center for ... the refereed journal PLOS ONE . , ... framework "is a new way of thinking in the biomedical ...
... prepping for a hurricane, the bacterium Bacillus subtilis ... times. In a new study, scientists at Rice University and ... B. subtilis to begin preparing for survival, even ... down" and withdraw into a hardened spore. The new ...
Cached Biology News:Using computational biology for the annotation of proteins 2Using computational biology for the annotation of proteins 3Scanning innovation can improve personalized medicine 2Scanning innovation can improve personalized medicine 3Deciphering bacterial doomsday decisions 2Deciphering bacterial doomsday decisions 3
(Date:7/30/2014)... July 30, 2014 Yuma Regional ... and complementary therapies brings comprehensive cancer care to ... Yuma Regional Cancer Center has officially opened. A ... program includes services such as open, semi-private and ... American Cancer Society Resource Center, hematology, rehabilitation center, ...
(Date:7/30/2014)... Md. , July 30, 2014 ... components to interrogate biology, but such devices can ... As such, researchers have looked ... in vitro metabolic engineering to characterize ... a chip. New devices are envisioned to recreate ...
(Date:7/30/2014)... , July 30, 2014  RXi Pharmaceuticals ... biotechnology company focused on discovering, developing and ... needs using RNA-targeted technologies, today announced that ... RXI-109, for the reduction of recurrence of ... has been initiated. Logo - ...
(Date:7/30/2014)... San Diego, CA (PRWEB) July 30, 2014 ... second contract from the U.S. Environmental Protection Agency ... company’s expertise in developmental toxicity models, including tests ... on neuron formation and the formation of connections ... function. Inhibition of neurodifferentiation and synapse formation by ...
Breaking Biology Technology:Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3
... than a Thousand Submissions Already Received for the ... USCAMBRIDGE, Mass., Jan. 15 The Nano Science ... and Sustainable Industries Organization (CTSI), today announced that ... the largest Cleantechnology, Biotechnology and Nanotechnology event in ...
... 15 The Court of ... found Boston Scientific Corporation,s Ding patent invalid, and reversed ... Coronary Stent infringed that patent. Cordis is very pleased ... rendered in July 2005 in Wilmington, Delaware. The ...
... have entered into a research collaboration to improve insect control in ... ... Research Triangle Park, NC (Vocus) January 15, 2009 -– DuPont and ... improve insect control in corn and soybeans. Under the agreement, ...
Cached Biology Technology:TechConnect World 2009 Announces January 28th 'Last Call' for Speaker-Proposals 2TechConnect World 2009 Announces January 28th 'Last Call' for Speaker-Proposals 3DuPont and Athenix Collaborate to Advance Insect Control in Corn, Soybeans 2DuPont and Athenix Collaborate to Advance Insect Control in Corn, Soybeans 3
...
... Kit is an advanced system for isolating DNA from ... be used directly for any downstream application. ... to use in 56 minutes Low melting point ... and TBE gels No specialised equipment required ...
... Spin Columns provide a rapid and simple method ... bp to 10 kb) from stained agarose gels ... excised from an agarose gel and loaded into ... the column are a series of membranes and ...
... Kit has been designed for recovery of DNA from ... Features Ultra fast protocol: DNA is ready ... are easy to resuspend Bead uniformity prevents shearing ... (suitable for PCR) DNA is eluted into sterile ...
Biology Products: