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New science of metagenomics 'will transform modern microbiology'

of the Center for Microbial Ecology, Michigan State University, East Lansing.

The goal of the large projects should be to characterize in great detail carefully chosen microbial communities in habitats worldwide, the report says. These studies could unite scientists from multiple disciplines around the study of a particular sample, habitat, function, or analytical challenge, the report adds. For example, one large project could focus on the microbial community associated with the human body, while others could focus on soil and seawater, or managed environments such as sludge processing sites.

The large projects would be "virtual" centers collecting data from scientists working at many locations around the world, and would probably need to be sustained for 10 years, the report notes. They would also serve as incubators for the development of novel techniques and community databases that would inform investigators running smaller experiments. In addition, the large studies would provide the "big science" appeal that is often useful in igniting public interest.

The metagenomics research community will include scientists funded by many government agencies working on many different habitats. These scientists should be encouraged to work together to disseminate advances, agree on common standards, and develop guidelines for best practices, the committee said. Such collaboration between government agencies should be facilitated by a group like the Microbe Project, an interagency committee that was formed in 2000 to advance "genome-enabled microbial science."

Noting that the data generated by the Human Genome Project were quickly made available in a public database, making them more valuable to researchers, the committee urged that metagenomic data likewise be made publicly available in international archives as rapidly as possible. The databases should include not only gene sequences but also information about sampling
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Source:The National Academies


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