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New results validating Pall prion reduction filter disclosed at ISBT Congress

detect vCJD. Although tests are in development by several companies, no solutions are likely in the short-term. He reviewed the complexity of developing accurate and reliable tests that would meet the required criteria including sensitivity and specificity. The implementation of donor screening would be problematic without the availability of confirmatory assays to inform discussions with potentially infected donors.

Prion Reduction Confirmed

Sam Coker, Ph.D., Principal Scientist of Pall Corporation, released new research results that further support the performance of the Leukotrap Affinity Prion Reduction Filter System. The study, conducted with the Departments of Neurology, Psychiatry and Pathology of the New York University School of Medicine, tested the filter against sporadic CJD. Sporadic CJD is the most common form of prion disease that affects humans. The new research showed a 99.9 percent reduction of the prion.

"This study, a first with an actual human form of prion disease, provides additional confirmation of the performance of our technology to remove all types of prions that can adversely affect people," said Dr. Coker. The sporadic CJD study is the latest in a series of studies of the filter's capability in reducing prions, including scrapie (a prion disease affecting sheep) and mouse-adapted human vCJD. He also reviewed results of new studies that found the filter effectively reduced prions under a range of different blood processing conditions, which may vary by country and blood center.

Allan Ross, President of Pall Medical, who opened the symposium, noted that concerns about vCJD are not limited to the UK and Europe, but that the disease has manifested itself in many countries around the globe. A total of 177 people have died or been diagnosed with vCJD in Britain, Ireland, France, Canada, Italy, Portugal, the Netherlands, Japan and the U.S. This past month France identified its 13th person with vCJD and Portugal a
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Source:Pall Corporation


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